A5101821421- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Historical and Religious Studies of Rome
- Caveolin-1 and cellular processes
- Cardiomyopathy and Myosin Studies
- Medieval Literature and History
- Congenital heart defects research
- COVID-19 Clinical Research Studies
- Ion channel regulation and function
- GNSS positioning and interference
- Medieval Architecture and Archaeology
- Ancient Mediterranean Archaeology and History
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- ECG Monitoring and Analysis
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Inertial Sensor and Navigation
- Byzantine Studies and History
- Historical Art and Culture Studies
- Wind and Air Flow Studies
- Archaeological Research and Protection
- Solar Energy Systems and Technologies
New York University
2016-2025
Western University
2025
Severance Hospital
2025
Yonsei University
2023-2025
NYU Langone Health
2014-2024
Courtauld Institute of Art
2007-2024
New York City Department of Health and Mental Hygiene
2024
Brown University
2024
St. Jude Medical Center
2019-2024
Bellevue Hospital Center
2024
First Page
Caveolae organelles and caveolin-1 protein expression are most abundant in adipocytes endothelial cells. Our initial report on mice lacking (Cav-1) demonstrated a loss of caveolae perturbations cell function. More recently, however, observation the Cav-1-deficient cohorts into old age revealed significantly lower body weights, as compared with wild-type controls. These results suggest that Cav-1 null may have problems lipid metabolism and/or adipocyte functioning. To test this hypothesis...
First Page
There is no known effective therapy for patients with coronavirus disease 2019 (COVID-19). Initial reports suggesting the potential benefit of hydroxychloroquine/azithromycin (HY/AZ) have resulted in massive adoption this combination worldwide. However, while true efficacy regimen unknown, initial raised concerns about risk QT interval prolongation and induction torsade de pointes (TdP).
The role of endothelial cell caveolae in the uptake and transport macromolecules from blood-space to tissue-space remains controversial. To address this issue directly, we employed caveolin-1 gene knock-out mice that lack protein expression organelles. Here, show are required for efficient a known caveolar ligand, <i>i.e.</i> albumin,<i>in vivo</i>. Caveolin-1-null were perfused with 5-nm gold-conjugated albumin, its was followed by transmission electron microscopy. Our results indicate...
A growing body of evidence suggests that muscle cell caveolae may function as specialized membrane micro-domains in which the dystrophin-glycoprotein complex and cellular signaling molecules reside. Caveolin-3 (Cav-3) is only caveolin family member expressed striated types (cardiac skeletal). Interestingly, skeletal fibers from Cav-3 (-/-) knock-out mice show a number myopathic changes, consistent with mild-to-moderate muscular dystrophy phenotype. However, it remains unknown whether loss...
Recently, development of a caveolin-1-deficient (Cav-1 null) mouse model has allowed the detailed analysis caveolin-1's function in context whole animal. Interestingly, we now report that hearts Cav-1 null mice are markedly abnormal, despite fact caveolin-1 is not expressed cardiac myocytes. However, abundantly nonmyocytic cells heart, i.e., fibroblasts and endothelia. Quantitative imaging studies demonstrate significantly enlarged right ventricular cavity thickened left wall with decreased...
The development of atherosclerosis is a process characterized by the accumulation lipids in form modified lipoproteins subendothelial space. This initiating step followed subsequent recruitment and proliferation other cell types, including monocytes/macrophages smooth muscle cells. Here, we evaluate potential role caveolae membrane domains pathogenesis using apolipoprotein E-deficient (ApoE-/-) mice as model system.Caveolin-1 (Cav-1) principal structural protein component domains. To...
The field of communication is characterized in large part by a barely-contained eclecticism that has often been thought to undermine the field’s claims legitimacy. Communication scholars wrestle...
MicroRNA cluster miR-17-92 has been implicated in cardiovascular development and function, yet its precise mechanisms of action these contexts are uncertain. This study aimed to investigate the role morphogenesis function cardiac smooth muscle tissues. To do so, a mouse model conditional overexpression tissues was generated. Extensive functional studies identified dose-dependent induction dilated, hypertrophic cardiomyopathy, arrhythmia inducibility transgenic animals, which correlated with...
Abstract We report the change in QT interval 84 adult patients with SARS-CoV-2 infection treated Hydroxychloroquine/Azithromycin combination. QTc prolonged maximally from baseline between days 3 and 4. 30% of increased by greater than 40ms. In 11% to >500 ms, representing high risk group for arrhythmia. The development acute renal failure but not was a strong predictor extreme prolongation.
SCN5A encodes the α subunit of major cardiac sodium channel Na(V)1.5. Mutations in are associated with conduction disease and ventricular fibrillation (VF); however, mechanisms that link loss function to arrhythmic instability remain unresolved. Here, we generated a large-animal model human channelopathy pigs, which have structure similar humans, better define substrate. We introduced nonsense mutation originally identified child Brugada syndrome into orthologous position (E558X) pig gene....
ABSTRACT Section 1502 of the Dodd–Frank Act requires SEC‐registered issuers to conduct supply chain due diligence and submit conflict minerals disclosures (CMDs) that indicate whether their products contain tantalum, tin, tungsten, or gold (3TG) sourced from Democratic Republic Congo (DRC) its neighboring countries (“covered countries”). Consistent with reputational cost hypothesis, we find heightened public attention CMDs increases responsible sourcing. After takes effect, higher demand for...
The level of caveolin-1 expression closely correlates with the oncogenic transformation NIH 3T3 cells, proliferation human cancer and differentiation adipocytes muscle cells. However, role in endothelial cell remains unknown. Here, we have shown that angiogenic growth factors stimulate lead to dramatic reductions expression. In addition, using an <i>in vitro</i>Matrigel assay system, studied potential capillary-like tubule formation (<i>i.e.</i> differentiation) microvascular cells (HMEC-1)....
Caveolae are 50−100 nm flask-shaped invaginations of the plasma membrane found in most cell types. Caveolin-1 is principal protein component caveolae membranes nonmuscle cells. The recent development Cav-1-deficient mice has allowed investigators to study vivo functional role context a whole animal model, as these lack morphologically detectable domains. Surprisingly, Cav-1 null both viable and fertile. However, it remains unknown whether loss caveolin-1 significantly affects overall life...