A5003880456- Pesticide and Herbicide Environmental Studies
- Cardiovascular Function and Risk Factors
- Pharmaceutical and Antibiotic Environmental Impacts
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Plasmonic and Surface Plasmon Research
- Advanced Biosensing Techniques and Applications
- Optical Coatings and Gratings
- Cardiac Ischemia and Reperfusion
- Adipokines, Inflammation, and Metabolic Diseases
- Electrochemical Analysis and Applications
- Tissue Engineering and Regenerative Medicine
- Atherosclerosis and Cardiovascular Diseases
- Congenital heart defects research
- Environmental Toxicology and Ecotoxicology
- Cholinesterase and Neurodegenerative Diseases
- Cardiac Fibrosis and Remodeling
- Electrowetting and Microfluidic Technologies
- Phytochemistry and Bioactivity Studies
- Chromium effects and bioremediation
- Plant Stress Responses and Tolerance
- Renal and Vascular Pathologies
- Cardiovascular and exercise physiology
- EEG and Brain-Computer Interfaces
- Phosphodiesterase function and regulation
Northeast Agricultural University
2019-2024
Sun Yat-sen University
2010-2023
Xi'an Jiaotong University
2023
Tsinghua University
2014-2020
Columbia University
2009
University of Illinois Chicago
2007
Memory loss, synaptic dysfunction, and accumulation of amyloid β-peptides (Aβ) are major hallmarks Alzheimer9s disease (AD). Downregulation the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding (CREB) cascade has been linked to deficits after Aβ elevation. Here, we report that phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a molecule enhances phosphorylation CREB, involved in memory, through elevation cGMP levels, is beneficial against AD phenotype...
Abstract Diabetic cardiomyopathy is a primary myocardial injury induced by diabetes with complex pathogenesis. In this study, we identify disordered cardiac retinol metabolism in type 2 diabetic male mice and patients characterized overload, all-trans retinoic acid deficiency. By supplementing or acid, demonstrate that both overload deficiency promote cardiomyopathy. Mechanistically, constructing cardiomyocyte-specific conditional dehydrogenase 10-knockout overexpressing 10 via...
Background: Little is known about the pathophysiological diversity of myocardial injury in type 2 diabetes mellitus (T2DM), but analyzing these differences important for accurate diagnosis and precise treatment diabetic cardiomyopathy. This study aimed to elucidate key cardiac between obese non-obese T2DM from mice humans. Methods: Obese mouse models were successfully constructed observed until systolic dysfunction occurred. Changes structure, function, energy metabolism oxidative stress...
As a biological pump, the heart needs to consume substantial amount of energy maintain sustained beating. Myocardial metabolism was recently reported be related loss proliferative capacity in cardiomyocytes (CMs). However, intrinsic relationship between beating rate and proliferation CMs whether can regulate this remains unclear. In study, we find that moderate reduction (HRR) induces CM under physiological conditions promotes cardiac regenerative repair after myocardial injury....
Epithelial/fibroblastic cross-talk is consider to lead pulmonary fibrosis, but its pathogenesis remains unclear because no appropriate models allow visualize the complex disease processes at human lung epithelial–interstitial interface.
Pearl millet (Pennisetum americanum (L.) K. Schum) has been proven as a potential remediation plant of the pollution caused by atrazine. Plants used in can release root exudates to communicate with rhizosphere microorganisms and accelerate removal pollutants soil. However, response pearl under atrazine stress remained unclear. In this study, hydroponic experiments were conducted at Northeast Agricultural University, Harbin, China, investigate oxidative changes composition plants that exposed...
An electrical double layer (EDL) is a specific distribution of ions at the electrolyte/electrode interface. As EDL plays decisive role in interfacial physical and chemical characteristics, comprehensive quantitative understanding structure its change dynamics important for wide range fields, ranging from electrochemistry, energy storage semiconductor materials to biotechnology. In this paper, we proposed proof concept method temporal- spatial-resolved mapping dynamics. A potential was...
Background Endothelial cell injury, induced by dyslipidemia, is the initiation of atherosclerosis, resulting in an imbalance endothelial fatty acid ( FA ) transport. Pigment epithelial‐derived factor PEDF important regulator lipid metabolism. We hypothesized that involved endothelium‐mediated uptake under hyperlipidemic conditions. Methods and Results Circulating levels were higher patients with atherosclerotic cardiovascular disease than normal individuals. However, decreasing trends serum...
A novel microfluidic flow rate detection method based on surface plasmon resonance (SPR) temperature imaging is proposed. The measurement performed by space-resolved SPR of the induced variations. Theoretical simulations and analysis were to demonstrate a proof concept using this approach. Experiments implemented results showed that water rates within wide range tens hundreds μL/min could be detected. sensor resistant disturbances can easily integrated into lab-on-chip systems.
A surface plasmon resonance (SPR) imaging method for monitoring the electric double-layer (EDL) change dynamics in real-time and map lateral EDL distribution on heterogeneous electrode/electrolyte interface.
A two-compartment microfluidic device integrated with a surface plasmon resonance (SPR) interferometric imaging system has been developed for long-term and real-time cell detection. The uses porous membrane sandwiched between two chambers to obtain an exact medium exchange rate minimal fluid shear stress culture. was optimized by COMSOL simulations fabricated using Poly (dimethylsiloxane) elastomer replica molding methods. To confirm the capability of maintain physiological environment over...
A simple but quantitative mathematical formalism was developed for interpretation of the SPR response from living cell attachment.
The technique used for electrode insertion navigation is of crucial importance neural signal collection.
Wang, C.1; LIU, L.2; CHEN, L.3; DENG, S.4; FEI, J.4; QIU, J.3; LI, Teng, L.5 Author Information