A5088151199- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Fish Ecology and Management Studies
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Phosphodiesterase function and regulation
- Environmental Toxicology and Ecotoxicology
- Cholinesterase and Neurodegenerative Diseases
- Neuroendocrine regulation and behavior
- Fish Biology and Ecology Studies
- Signaling Pathways in Disease
- Mitochondrial Function and Pathology
- Aquaculture Nutrition and Growth
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Behavior and Welfare Studies
- Biochemical effects in animals
- GDF15 and Related Biomarkers
- Marine and fisheries research
- Axon Guidance and Neuronal Signaling
- 14-3-3 protein interactions
- Ubiquitin and proteasome pathways
University of Warwick
2017-2024
University of Dundee
2019-2024
University of Bradford
2019-2023
University of Edinburgh
2019-2023
University of Malta
2022-2023
Ninewells Hospital
2019-2022
Centre for Environment, Fisheries and Aquaculture Science
2008-2018
University of Catania
2008-2014
Columbia University
2008-2010
Columbia University Irving Medical Center
2009
Amyloid-β (Aβ) peptides are produced in high amounts during Alzheimer's disease, causing synaptic and memory dysfunction. However, they also released lower normal brains throughout life activity. Here we show that low picomolar concentrations of a preparation containing both Aβ 42 monomers oligomers cause marked increase hippocampal long-term potentiation, whereas nanomolar lead to the well established reduction potentiation. Picomolar levels produce pronounced enhancement reference...
Memory loss, synaptic dysfunction, and accumulation of amyloid β-peptides (Aβ) are major hallmarks Alzheimer9s disease (AD). Downregulation the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding (CREB) cascade has been linked to deficits after Aβ elevation. Here, we report that phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a molecule enhances phosphorylation CREB, involved in memory, through elevation cGMP levels, is beneficial against AD phenotype...
The goal of this study was to investigate the role endogenous amyloid-β peptide (Aβ) in healthy brain.Long-term potentiation (LTP), a type synaptic plasticity that is thought be associated with learning and memory, examined through extracellular field recordings from CA1 region hippocampal slices, whereas behavioral techniques were used assess contextual fear memory reference memory. Amyloid precursor protein (APP) expression reduced small interfering RNA (siRNA) technique.We found both...
Alzheimer's disease is one of the most common causes death worldwide, with poor treatment options. A tissue landmark accumulation anomalous protein amyloid-β in specific brain areas. Whether inflammation an effect on brain, or rather it represents a cause for formation amyloid plaques and intracellular tangles remains subject debate. TNFSF10, proapoptotic cytokine TNF superfamily, mediator neurotoxicity. Here, we demonstrate that blocking TNFSF10 by administration neutralizing monoclonal...
Memory formation is typically divided into phases associated with encoding, storage, consolidation, and retrieval. The neural determinants of these are thought to differ. This study first investigated the impact experience novelty in rats incurred at a different time, before or after, precise moment memory encoding. retention was enhanced. Optogenetic activation locus coeruleus mimicked this enhancement induced by novelty, both when given after also slow-onset potentiation field potentials...
F3/contactin, a cell-adhesion molecule belonging to the immunoglobulin supergene family, is involved in several aspects of neural development including synapse building, maintenance and functioning. Here, we examine F3/contactin function adult hippocampal neurogenesis, synaptic plasticity, memory, using as model TAG/F3 transgenic mice, where overexpression was induced under control regulatory sequences from human TAG-1 (TAX-1) gene. Transgenic mice aged 5 (M5) 12 (M12) months exhibited an...
Cyclic adenosine monophosphate (cAMP) regulates long‐term potentiation (LTP) and ameliorates memory in healthy diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression formation. Here, we report that cAMP controls precursor protein (APP) translation Aβ levels, the modulatory effects on occur through stimulation APP synthesis production. Ann Neurol 2014;75:602–607
A key aim of Alzheimer disease research is to develop efficient therapies prevent and/or delay the irreversible progression cognitive impairments. Early deficits in long-term potentiation (LTP) are associated with accumulation amyloid beta rodent models disease; however, less known about how mGluR-mediated depression (mGluR-LTD) affected. In this study, we have found that mGluR-LTD enhanced APPswe /PS1dE9 mouse at 7 but returns wild-type levels 13 months age. This transient over-activation...
Abstract The later stages of long-term potentiation (LTP) in vitro and spatial memory vivo are believed to depend upon gene transcription. Accordingly, considerable attempts have been made identify both the mechanisms by which transcription is regulated indeed products themselves. Previous studies shown that deletion one regulator transcription, mitogen- stress-activated kinase 1 (MSK1), causes an impairment memory. Given ability MSK1 regulate expression via phosphorylation cAMP response...
Summary About 25 % of juvenile Atlantic salmon ( Salmo salar ) migrating downstream in the River Frome southern England do so autumn rather than spring. Here, we examine physiological status these fish with regard to those features that adapt them sea water during parr–smolt transformation (i.e. gill Na + K ATPase activity; number, size and type chloride cells on lamellae; salinity tolerance relative plasma thyroid levels). Autumn migrants, which subsequently reside tidal reaches winter, are...
Experience powerfully influences neuronal function and cognitive performance, but the cellular molecular events underlying experience-dependent enhancement of mental ability have remained elusive. In particular, mechanisms that couple external environment to genomic changes underpinning this improvement are unknown. To address this, we used male mice harboring an inactivating mutation mitogen- stress-activated protein kinase 1 (MSK1), a brain-derived neurotrophic factor (BDNF)-activated...
Abstract Atlantic salmon, Salmo salar L., smolts were exposed to environmental levels of the pesticide atrazine in a hatchery, tagged with acoustic transmitters and released into fresh water at peak smolt run. The subsequent movements monitored within freshwater immediate coastal zones using an array receivers. In laboratory‐based studies, exposure 0.1 μg L −1 concentration over 72‐h period significantly reduced gill Na + K ATPase activity but not plasma thyroxine (T 4 ) triiodothyronine 3...
The immediate early gene activity‐regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain‐derived neurotrophic factor (BDNF) play important roles in synaptic plasticity learning memory mammalian brain. However, mechanisms by which BDNF regulates expression of Arc/Arg3.1 are unclear. In this study, we show that acts via ERK1/2 pathway to activate nuclear kinase mitogen‐ stress‐activated 1 (MSK1). MSK1 then induces phosphorylation histone H3 at promoter. can also phosphorylate...
The transcription factor cAMP response element-binding protein (CREB) is widely regarded as orchestrating the genomic that underpins a range of physiological functions in central nervous system, including learning and memory. Of means by which CREB can be regulated, emphasis has been placed on phosphorylation key serine residue, S133, protein, required for CREB-mediated transcriptional activation to variety activity-dependent stimuli. Understanding role S133 complicated molecular genetic...
There is considerable interest in the development of nootropics, pharmacological agents that can improve cognition across a range both cognitive modalities and disabilities. One class enhancers, ampakines, has attracted particular attention by virtue improving associated with animal models neurodevelopmental, neurodegenerative, psychiatric conditions, as well age-related impairment. Ampakines elevate CNS levels BDNF, it through this elevation their beneficial actions are believed to occur....
Positive experiences, such as social interaction, cognitive training and physical exercise, have been shown to ameliorate some of the harms cognition associated with ageing. Animal models positive interventions, commonly known environmental enrichment, strongly influence neuronal morphology synaptic function enhance performance. While profound structural functional benefits enrichment appreciated for decades, little is how environment influences neurons respond adapt these sensory...
Abstract Migrating silver European eels were exposed for 5 days in a laboratory to an environmental level of tributyl phosphate ( TBP ), tagged with acoustic transmitters and released below the T ange hydropower station, on R iver G udenaa, D enmark. The subsequent movements monitored as they migrated through anders F jord into K attegat S ea using array receivers. In laboratory‐based studies, exposure nominal concentration 0.5 μg·l −1 significantly affected plasma glucose reduced levels...
The potential effects of a hydropower scheme on the migratory behaviour Atlantic salmon Salmo salar smolts was studied River Frome, southern England. delay to migration at intake assessed, together with passage through turbine temporal and spatial fish in river estuary. emigrating S. monitored using miniature acoustic transmitters an array receivers positioned majority bypassed only 8.1% moving downstream turbine. Movement nocturnal occurred during elevated flows. There no apparent or...