A5008041720- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Neurological Complications and Syndromes
- Central Venous Catheters and Hemodialysis
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Research Studies
- Vasculitis and related conditions
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Bone and Joint Diseases
- Alzheimer's disease research and treatments
- Kidney Stones and Urolithiasis Treatments
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Cardiac tumors and thrombi
- Sepsis Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
University of Wisconsin–Madison
2017-2024
UW Health University Hospital
2020-2023
Karachi Institute of Economics and Technology
2022
Foreign Agricultural Service
2022
Tengku Ampuan Rahimah Hospital
2021
Hospital Tuanku Ja’afar
2021
Allama Iqbal Open University
2020
University of Missouri
2017
Penn State Milton S. Hershey Medical Center
2013
Wake Forest University
2013
The goal of this study was to investigate the role endogenous amyloid-β peptide (Aβ) in healthy brain.Long-term potentiation (LTP), a type synaptic plasticity that is thought be associated with learning and memory, examined through extracellular field recordings from CA1 region hippocampal slices, whereas behavioral techniques were used assess contextual fear memory reference memory. Amyloid precursor protein (APP) expression reduced small interfering RNA (siRNA) technique.We found both...
This phase II trial was conducted to evaluate the safety and efficacy of concurrent gemcitabine high-intensity focused ultrasound (HIFU) therapy in patients with locally advanced pancreatic cancer. Patients localized unresectable adenocarcinoma head or body pancreas received (1000 mg/m) intravenously over 30 min on days 1, 8, 15, HIFU 3, 5. The treatment given every 28 days. Thirty-seven (94.9%) 39 were assessable for response, two cases complete response 15 partial confirmed, giving an...
ObjectiveThe purpose of this study was to detect the presence cancer stem-like cells with bronchioalveolar stem (BASCs) properties and investigate clinicopathological role expression OCT4 as well correlation clinical outcomes in adenocarcinoma lung.
There is limited information on treatment strategies and monitoring for late antibody-mediated rejection (ABMR) after kidney transplantation.In this observational nonrandomized study, we compared 78 patients diagnosed with ABMR (>3 months transplant) who were treated standard of care steroids/IVIG (n = 38) ± rituximab 40) at our center between March 1, 2013 December 31, 2016. All had follow-up biopsy donor-specific antibodies (DSA) within 3 to 12 weeks.Patients 7.3 7 years transplant...
Background. Limited information exists about outcomes of HLA donor-specific antibody (DSA) negative (DSA−) microvascular inflammation (MVI). Methods. We report our experience with 25 DSA− patients MVI compared to 155 DSA+ who met Banff 2013 criteria for antibody-mediated rejection (AMR). also 228 whose biopsies were and served as a control. Results. There no significant differences in the baseline characteristics between AMR groups. At time diagnosis, both groups had similar graft function....
Donor-specific antibodies (DSAs) are considered an important risk factor for graft injury and failure. However, there is limited information on long-term outcomes kidney transplant recipients with positive DSAs in the absence of rejection biopsy.We evaluated all patients at University Wisconsin who underwent a allograft biopsy between January 1, 2013, December 31, 2016. All clinical indication or protocol biopsies that were negative acute lacked significant pathological features included...
Development of de novo donor-specific antibodies (dnDSA) has detrimental effects on graft survival in several types solid organ transplants. However, limited information exists about the effect dnDSA pancreas transplant survival.We report our experience with recipients transplanted between January 01, 2005, and August 31, 2017.We identified 541 recipients, which 121 developed 420 did not. Thirty-two percent against HLA class I antigens, 56% II 12% both. Fifty-two patients dnDSA+ 24% dnDSA-...
There is conflicting information on current medical and surgical complications associated with high body mass index (BMI) after kidney transplantation.In a single-center observational study, we analyzed the 5-year outcomes of all consecutive primary transplant recipients between 2010 2015 based BMI at time transplant.There were 1,467 patients included in this distributed following groups BMI: underweight (n = 32, 2.2%), normal 407, 27.7%), overweight 477, 32.5%), grade I obesity 387, 26.4%),...
Limited published data exist to guide the treatment of pancreas transplant rejection.We reviewed and outcomes 158 first episodes biopsy-proven rejection between 1 January 1997 31 December 2016. Within each Banff grade rejection, we compared response rates long-term with steroids alone versus plus antithymocyte globulin (ATG).Of recipients 65 were treated alone. Eighty-three percent patients I, 60% II, 33.33% III responded Ninety-three ATG. The 69% in 76% 73% III. Response graft survival not...
Abstract Background The existence of circulating tumor cells (CTCs) in peripheral blood as an indicator recurrence has not been clearly established, particularly for gastric cancer patients. We conducted a retrospective analysis the relationship between CTCs at initial diagnosis and clinicopathologic findings patients with carcinoma. Methods Blood samples were obtained from 123 carcinoma diagnosis. mRNA was extracted amplified carcinoembryonic antigen (CEA) detection using real-time RT-PCR....
Acute aortic dissection is a rare clinical entity that mainly affects patients older than 50 years. It unusual in younger and its presence has been traditionally associated with trauma, Marfan syndrome, bicuspid valve pregnancy. We present here, case of 30 year old pregnant female acute type A (De Bakey II), without family history connective tissue diseases signs syndrome.
Serotonin 4 (5-HT4) receptor signaling does not only have the physiological function of improving cognition, but might also be helpful in therapy Alzheimer's disease (AD) through regulation production soluble amyloid-β protein precursor alpha (sAβPPα). To analyze relationship between 5-HT4 and sAβPPα production, we stably transfected H4 cells with AβPP (H4/AβPP/5-HT4 cells). We found that 24-h incubation agonist RS-67333 upregulates matrix metalloproteinase-9 (MMP-9). Furthermore, MMP-9...
The first simultaneous pancreas and kidney (SPK) transplant was performed in 1966. Early procedures were associated with significant morbidity mortality very low numbers select patients.This study includes all recipients of an SPK at the University Wisconsin-Madison between 1986 1993, who actively followed had a functional allograft for >25 years as October 31, 2018.A total 291 during period; these, 39 patients still graft last follow up 9 (18.8%) grafts lost due to patient death or failure...
Cerebral hemorrhage occurs rarely in infective endocarditis. Here, we present an interesting case of endocarditis complicated by sever cerebral hemorrhage. Later, his blood culture grew S bovis. To the best our knowledge, this is first ever reported Bovis extensive intracranial
Background. There is limited information about the utility of donor-specific antibody (DSA) against HLA monitoring and role protocol kidney biopsy for de novo DSA (dnDSA) in simultaneous liver (SLK) transplant recipients. Methods. We analyzed SLK recipients transplanted between January 2005 December 2017, who had checked posttransplant. Patients were divided into 2 groups based on whether they developed dnDSA posttransplant (dnDSA+) or not (dnDSA−). Kidney graft rejection ±45 d a...
Peritoneal dialysis (PD) has been used increasingly in past decade. Many of these patients undergo transplantation and may require for delayed graft function (DGF). The outcomes DGF based on the post-transplantation modality are not well known.
Given the potential morbidity of traditional chest tube insertion, use pigtail is desirable. The purpose this case series to determine efficacy bedside thoracostomy catheters in Adult population by using ultrasound pulmonologists.It a retrospective series, which describes importance placements for emergent symptomatic relief patients. Predicting successful drainage, procedure complex and multifactorial process based on size, location, character configuration abscess.Our experience shows that...