A5051238284- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Advanced biosensing and bioanalysis techniques
- Adenosine and Purinergic Signaling
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Silymarin and Mushroom Poisoning
- Heme Oxygenase-1 and Carbon Monoxide
- Colorectal Cancer Treatments and Studies
- Endometriosis Research and Treatment
- Lung Cancer Research Studies
Zhongshan Hospital
2017-2025
Fudan University
2017-2025
Sichuan University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Sun Yat-sen University
2019-2024
State Key Laboratory of Biotherapy
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Jiangnan University
2022-2024
West China Second University Hospital of Sichuan University
2021-2024
Liaoning University of Traditional Chinese Medicine
2024
<h3>Background</h3> CD8<sup>+</sup> T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity. A detailed characterization of and their prognostic value in HCC is lacking. <h3>Methods</h3> We collected fresh tumor tissues with adjacent non-tumor liver blood specimens 56 patients, as well archived samples from two independent cohorts patients (<i>n</i> = 358 <i>n</i> 254), who...
Radiomics is an emerging field in oncological research. In this study, we aimed at developing a radiomics score (rad-score) to estimate postoperative recurrence and survival patients with solitary hepatocellular carcinoma (HCC).A total of 319 HCC (training cohort: n = 212; validation 107) were enrolled. features extracted from the artery phase preoperatively acquired computed tomography (CT) all patients. A rad-score was generated by using least absolute shrinkage selection operator (lasso)...
Chemokines play a key role in orchestrating the recruitment and positioning of myeloid cells within tumor microenvironment. However, tropism regulation functions these hepatocellular carcinoma (HCC) are not completely understood. Herein, by scrutinizing expression all chemokines HCC cell lines tissues, we found that CCL15 was most abundantly expressed chemokine human HCC. Further analyses showed regulated genetic, epigenetic, microenvironmental factors, negatively correlated with patient...
As a major cellular component in tumor microenvironment, the distribution, frequency, and prognostic significance of infiltrating B cell subsets hepatocellular carcinoma (HCC) remain controversial. Using tyramide signal amplification (TSA) based fluorescent multiplexed immunohistochemistry situ, we evaluated distribution frequency two independent HCC cohorts (n = 619). The results were further confirmed by flow cytometry. Correlations with clinicopathologic features patient prognosis...
With the increasing demand for innovative therapies, biodegradable magnesium has attracted more and attention, which could avoid secondary surgery reduce complications. Until now, plenty of researchers take part in research & development this field, many articles have been published every year. However, it is a huge challenge to predict trends definite topics researchers, result low value, wasted resources even slowed medical device transformation. Usually, reviews summarize specific topic,...
Abstract Objective Immunotherapy targeting the programmed cell death protein-1 (PD-1)/programmed protein ligand 1 (PD-L1) pathway has been observed to be efficient in several solid tumors. We aim investigate prognostic significance of PD-1/PD-L1 expression profile intrahepatic cholangiocarcinoma (ICC). Materials and methods investigated PD-1, PD-L1, CD8 + T cells, CD68 macrophages paired tumor adjacent normal tissues from 322 ICC patients using tyramide signal amplification (TSA)-based...
Abstract Purpose To investigate the biological function and underlying mechanism of CD39 in cholangiocarcinoma. Methods Quantitative reverse transcription PCR (RT-qPCR), western blot (WB), immunohistochemistry staining was used to evaluate expression level Kaplan–Meier Cox hazard ratio regression analyses were implicated prognostic significance CD39. Cell counting kit-8 (CCK-8) carried out proliferative capacity, while transwell assay detect migration invasion ability. In addition, B-NDG...
ObjectiveThe purpose of this study was to detect the presence cancer stem-like cells with bronchioalveolar stem (BASCs) properties and investigate clinicopathological role expression OCT4 as well correlation clinical outcomes in adenocarcinoma lung.
Background and Objectives Frequently aberrant expression of cytokeratin 7 (CK7) 19 (CK19) have been observed in several human cancers. In this retrospective study, we aimed at investigating the prognostic significance CK7 CK19 intrahepatic cholangiocarcinoma (ICC). Methods Immunohistochemistry was performed to assess on tissue microarrays training cohort enrolling 214 ICC patients validation comprising 108 patients. Kaplan‐Meier analysis, Cox's proportional hazards regression, nomogram were...
Abstract Background This study aimed to investigate the clinical relevance of immune microenvironment in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC‐ICC). Patients Methods The density tumor‐infiltrating CD3 + , CD8 CD163 Foxp3 cells, as well Programmed cell death 1, death‐ligand Tumor necrosis factor receptor superfamily member 4, was measured peritumor liver, tumor invasive margin, intratumor subregions 56 cHCC‐ICC by immunohistochemistry. index established...
Endometriosis, a heterogeneous, inflammatory, and estrogen-dependent gynecological disease defined by the presence growth of endometrial tissues outside lining uterus, affects approximately 5-10% reproductive-age women, causing chronic pelvic pain reduced fertility. Although etiology endometriosis is still elusive, emerging evidence supports idea that immune dysregulation can promote survival retrograde debris. Peritoneal macrophages natural killer (NK) cells exhibit deficient cytotoxicity...
OBJECTIVES: In this study, we aimed at investigating the preoperatively available prognostic factors for intrahepatic cholangiocarcinoma (ICC) patients and proposing a new preoperative scoring system ICC. METHODS: A total of 246 consecutive ICC who underwent curative hepatectomy were enrolled retrospectively randomly divided into training (n=164) validation cohorts (n=82) ratio 2:1. The investigated in both using multivariate Cox's proportional hazards regression model. RESULTS: Multivariate...
Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in human cancers. However, the underlying biological functions and mechanisms of lncRNAs cholangiocarcinoma (CCA) remain largely unknown. We aimed characterize transcriptional landscape CCA identify that were able serve as prognosis markers therapeutic targets for CCA. Here, we investigated dysregulation LINC01714 was found be recurrently downregulated tumor samples. Our results revealed decreased expression associated with...
The MUC16 C-terminal (MUC16c) level is associated with tumor serum CA-125 levels, however, the roles remain unclear in gallbladder carcinoma (GBC). In this study, we found that MUC16c promoted glucose uptake and glycolysis for GBC cell proliferation. Mass spectrometry analysis suggested could combine aldolase. ALDOC mRNA protein are overexpressed tumors. IHC results also showed consistent up-regulation of. tissues than peritumor tissues. We determined combining stability disrupted ability of...