A5100353042- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Peripheral Artery Disease Management
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- RNA Research and Splicing
- Influenza Virus Research Studies
- Sexual function and dysfunction studies
- Cytokine Signaling Pathways and Interactions
- Nitric Oxide and Endothelin Effects
- IL-33, ST2, and ILC Pathways
- Cancer-related gene regulation
- Acupuncture Treatment Research Studies
- Ferroptosis and cancer prognosis
- Blood groups and transfusion
- Aortic aneurysm repair treatments
- Immune Cell Function and Interaction
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- Pulmonary Hypertension Research and Treatments
Taizhou Municipal Hospital
2025
Xiyuan Hospital
2016-2025
Affiliated Hospital of Hebei University
2024-2025
Fujian Institute of Oceanography
2025
Ministry of Natural Resources
2025
China Academy of Chinese Medical Sciences
2025
Shanghai Jiao Tong University
2009-2024
Shanghai University of Traditional Chinese Medicine
2019-2024
Shandong University
2012-2024
Huazhong University of Science and Technology
2011-2024
Genes in prokaryotic genomes are often arranged into clusters and co-transcribed polycistronic RNAs. Isolated examples of RNAs were also reported some higher eukaryotes but their presence was generally considered rare. Here we developed a long-read sequencing strategy to identify transcripts several mushroom forming fungal species including Plicaturopsis crispa, Phanerochaete chrysosporium, Trametes versicolor, Gloeophyllum trabeum. We found genome-wide prevalence transcription these...
Abstract Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) colorectal cancer (CRC). However, vivo functions and molecular mechanism UCA1 CRC remain unclear. Therefore, we investigated detailed role CRC. We found that was up-regulated CRCs negatively correlated with survival time two cohorts. Functional assays revealed growth-promoting function can decrease sensitivity cells to 5-FU by attenuating...
Purpose: Long non-coding RNAs (lncRNAs) play key roles in human cancers. Here, FEZF1-AS1, a highly overexpressed lncRNA colorectal cancer, was identified by microarrays. We aimed to explore the and possible molecular mechanisms of FEZF1-AS1 cancer.Experimental Design: LncRNA expression cancer tissues measured microarray qRT-PCR. The functional were demonstrated series vitro vivo experiments. RNA pull-down, immunoprecipitation luciferase analyses used demonstrate potential FEZF1-AS1.Results:...
Purpose: Tumor-associated macrophages (TAMs) are frequently associated with poor prognosis in human cancers. However, the effects of TAMs colorectal cancer contradictory. We therefore investigated functions, mechanisms, and clinical significance cancer.Experimental Design: measured macrophage infiltration (CD68), P-gp, Bcl2 expression tissues using IHC staining. Coculture cells both vitro vivo models was used to evaluate on chemoresistance. Cytokine antibody arrays, ELISA, neutralizing...
Long noncoding RNAs can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism hepatocarcinogenesis are largely unknown. Here, we report a novel suppressor long RNA on chromosome 8p12 (termed TSLNC8 ) that is frequently deleted down‐regulated hepatocellular carcinoma (HCC) tissues. The loss of highly associated with the malignant features HCC serves prognostic indicator for patients. significantly suppresses proliferation...
miR-204-5p was found to be downregulated in colorectal cancer tissues our preliminary microarray analyses. However, the function of remains unknown. We therefore investigated role, mechanism, and clinical significance development progression.We measured expression determined its correlation with patient prognoses. Ectopic cells, xenografts, pulmonary metastasis models used evaluate effects on proliferation, migration, chemotherapy sensitivity. Luciferase assay Western blotting were performed...
Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour suppressors involved in carcinogenesis. Here we characterized an oncogenic long intergenic non-coding RNA frequent DNA-gain regions hepatocellular carcinoma (HCC), LINC01138 (long located on 1q21.2). The locus is frequently amplified HCC; transcript stabilized by insulin like growth factor-2 mRNA-binding proteins 1/3 (IGF2BP1/IGF2BP3) and associated with malignant features poor outcomes HCC patients. acts as...
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression lung cancer. Here, we report the identification of a lncRNA signature associated with metastasis non-small cell cancer (NSCLC). In particular, elevated expression LINC00963 (MetaLnc9) human NSCLC specimens correlated poor prognosis, promoted migration invasion cells vitro, enhanced formation vivo Mechanistic investigations showed that MetaLnc9 interacted glycolytic kinase PGK1 prevented its ubiquitination cells,...
Long intergenic non-coding RNA 152 (LINC00152) is a recently identified tumor-promoting long RNA. However, the biological functions of LINC00152 in colorectal cancer (CRC) remain unclear and require further research. The aim present study to explore roles cellular function its possible molecular mechanism. In this study, we discovered that was overexpressed CRC tissues negatively related survival time patients. Functional analyses revealed could promote cell proliferation. Furthermore,...
Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements and play fundamental roles in the biology of various cancers. However, we still lack knowledge about their expression patterns functions human colorectal cancer (CRC).Differentially expressed lncRNAs CRC were identified by bioinformatics screen level MIR22HG control tissues determined qRT-PCR. Cell viability migration capacities examined MTT transwell assay. Mouse model was used to examine function rational...
Glioblastoma (GBM) is the most aggressive type of primary brain tumor and often resistant to current therapies. Tumor microenvironment-centered therapies may unleash new hope for GBM treatment. Therefore, an in-depth understanding tumor-stroma communication urgently needed identify promising therapeutic targets.We systematically analyzed single-cell RNA sequencing (scRNA-seq), bulk RNA-seq spatial scRNA-seq data from various human mice studies characterize network within microenvironment....
ABSTRACT MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of the role non-protein-coding RNAs carcinogenesis and metastasis. In this study, we described molecular mechanism miR-139-5p colorectal cancer (CRC) its potential clinical application CRC. We found was significantly downregulated 73.8% CRC samples compared with adjacent noncancerous tissues (NCTs), decreased associated poor prognosis. Functional analyses...
// Jiwei Zhang 1, * , Bojian Fei 2, Qifeng Wang 3 Mingxu Song 1 Yuan Yin Binbin Shujuan Ni Weijie Guo 4 Zehua Bian Chao Quan Zhihui Liu Yugang 5 Jian Yu 6 Xiang Du Dong Hua Zhaohui Huang Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214062, China 2 Department Surgical Oncology, Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Medical College, Urology, Michigan Comprehensive Ann Arbor, MI 48109-5942, USA State Key Laboratory...
MicroRNAs (miRNA) that are strongly implicated in carcinogenesis have recently reshaped our understanding of the role non-protein-coding RNAs. Here, we focused on function and molecular mechanism miR-202-3p its potential clinical application colorectal cancer.miR-202-3p expression was determined by quantitative reverse transcriptase PCR (qRT-PCR) 94 cancer tissues corresponding noncancerous (NCT). Cell proliferation colony formation assays vitro xenograft experiments vivo were used to...
DNA methylation, especially in promoter regions, is a well-characterized epigenetic marker related to gene expression regulation eukaryotes. However, the role of intragenic methylation usage corresponding exons still remains elusive. In this study, we described methylome across 10 human tissues. The genome showed both conserved and varied levels among these We found that densities promoters first were negatively correlated with level. Nevertheless, within introns, internal down 1 kb regions...
Abstract Aims The aim of this study was to report the incidence, prevalence, and disability‐adjusted life‐years (DALYs) periodontal diseases during period 1990–2019. Methods Data on were retrieved from Global Burden Diseases, Injuries, Risk Factors (GBD) 2019. estimated annual percentage changes calculated evaluate changing trend age‐standardized DALY rates related diseases. Results Globally, there 1,087,367,744.0 cases with 91,518,820.6 new incidence 7,090,390.3 DALYs in 2019, almost twice...
Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline-induced artery endothelial injury and hypertension remains unknown. extracellular calcium-sensing receptor (CaSR) particularly its domain hold the potential structural basis for monocrotaline bind. This study aimed reveal whether induces by targeting CaSR.Nuclear magnetic resonance screening through WaterLOGSY (water ligand-observed gradient spectroscopy)...
Mitochondria are essential for the onset of hypoxia-induced pulmonary vasoconstriction and vascular-remodeling, two major aspects underlying development hypertension, an incurable disease. However, hypoxia induces relaxation systemic arteries such as femoral mitochondrial heterogeneity controls distinct responses versus artery smooth muscle cells to in vitro. The aim this study was determine whether can be experimentally exploited vivo a potential treatment against hypertension. intact...
Abstract Bone metastasis is of common occurrence in renal cell carcinoma with poor prognosis, but no optimal treatment approach has been established for bone metastatic carcinoma. To explore the potential therapeutic targets carcinoma, we profile single transcriptomes 6 primary and 9 We also include scRNA-seq data early-stage late-stage normal kidneys healthy marrow samples study to better understand niche. The molecular properties dynamic changes major lineages environment are...
A novel KOH/KNO 3 co-activation method was reported to simply prepare high-performance porous carbon electrodes for the fabrication of supercapacitors.