A5100640564- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Vascular Malformations and Hemangiomas
- Ion Channels and Receptors
- Biomarkers in Disease Mechanisms
- Cardiac Imaging and Diagnostics
- Chemokine receptors and signaling
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Synthesis of Indole Derivatives
- Thermal properties of materials
- Colorectal Cancer Screening and Detection
- Angiogenesis and VEGF in Cancer
Wuxi People's Hospital
2020-2023
Wuxi Fourth People's Hospital
2010-2020
Second Hospital of Tianjin Medical University
2005-2019
Jiangnan University
2014-2019
Tianjin Medical University
2005-2019
The Fourth People's Hospital
2013-2017
Tianjin Medical University Cancer Institute and Hospital
2017
National Clinical Research
2017
Soochow University
2011-2014
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2011-2014
Purpose: Tumor-associated macrophages (TAMs) are frequently associated with poor prognosis in human cancers. However, the effects of TAMs colorectal cancer contradictory. We therefore investigated functions, mechanisms, and clinical significance cancer.Experimental Design: measured macrophage infiltration (CD68), P-gp, Bcl2 expression tissues using IHC staining. Coculture cells both vitro vivo models was used to evaluate on chemoresistance. Cytokine antibody arrays, ELISA, neutralizing...
miR-204-5p was found to be downregulated in colorectal cancer tissues our preliminary microarray analyses. However, the function of remains unknown. We therefore investigated role, mechanism, and clinical significance development progression.We measured expression determined its correlation with patient prognoses. Ectopic cells, xenografts, pulmonary metastasis models used evaluate effects on proliferation, migration, chemotherapy sensitivity. Luciferase assay Western blotting were performed...
Piperlongumine (PL), a natural alkaloid present in the fruit of Long pepper, is known to exhibit notable anti-cancer effects. Nonetheless, anti-tumor effect PL lung cancer cells still remains unclear. In study, we reported chemotherapeutic effects using vitro and vivo models. We showed that displayed potent anti-neoplastic activity against A549 as well corresponding docetaxel-resistant A549/DTX cells. addition, found induced apoptosis both also autophagy Moreover, autophagy-specific...
Inhibitory costimulatory molecule CD274 expresses in various cancers and contributes to cancer immune evasion by inhibiting T cell activation proliferation, yet the regulatory mechanisms for overexpression are poorly understood. In this study, we discovered a novel mechanism of expression regulated miR-570. A guanine-to-cytosine mutation at 3'-UTR mRNA led disrupting miR-570 binding. The mutations were widely observed sequencing 276 gastrointestinal (esophageal, gastric, colorectal,...
ABSTRACT MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of the role non-protein-coding RNAs carcinogenesis and metastasis. In this study, we described molecular mechanism miR-139-5p colorectal cancer (CRC) its potential clinical application CRC. We found was significantly downregulated 73.8% CRC samples compared with adjacent noncancerous tissues (NCTs), decreased associated poor prognosis. Functional analyses...
Chemoresistance, the major obstacle in breast cancer chemotherapy, results unnecessary chemotherapy and wasting of medical resources. No feasible method has been available to predict chemoresistance before chemotherapy. In our previous study, elevated expression transient receptor potential channel TRPC5 was found be an essential element for cells, it determined that could transferred chemosensitive cells through releasing extracellular vesicles (EV) containing from chemoresistant resulting...
// Jiwei Zhang 1, * , Bojian Fei 2, Qifeng Wang 3 Mingxu Song 1 Yuan Yin Binbin Shujuan Ni Weijie Guo 4 Zehua Bian Chao Quan Zhihui Liu Yugang 5 Jian Yu 6 Xiang Du Dong Hua Zhaohui Huang Wuxi Oncology Institute, the Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214062, China 2 Department Surgical Oncology, Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Medical College, Urology, Michigan Comprehensive Ann Arbor, MI 48109-5942, USA State Key Laboratory...
S100 is a superfamily of calcium-binding proteins that regulate multiple biological processes and are involved in many diseases. S100A16 has recently been identified to be several cancers such as bladder cancer, lung oral squamous cell carcinoma. However, the role expression colorectal cancer (CRC) not investigated.S100A16 protein was detected by immunohistochemistry 296 cases CRC. Kaplan-Meier survival analysis Cox regression were performed evaluate prognostic significance S100A16.The...
B7-H3, a member of the B7 family, has been reported to be highly expressed in colorectal cancer and is associated with poor prognosis overall survival. In this study, we found that overexpression B7-H3 protected SW80 HCT8 cells from 5-fluorouracil (5-FU) using CCK-8 assays by inducing resistance 5-FU chemotherapy. Further investigation revealed elevated expression thymidylate synthase (TS) upregulation PI3-kinase (PI3K)/Akt pathway overexpressing cells. The effects on activation PI3K/Akt...
Identification of effective biomarkers is crucial for monitoring the treatment and remission colorectal cancer (CRC) improving survival. It particularly important to diagnose CRC before tumor metastasizes (stage I–II disease) where possible, provide greatest opportunity patient recovery. Here, we evaluated clinical value serum chemokine (C-X-C) ligand 7 (CXCL7) concentration as a biomarker diagnosis. An enzyme-linked immunosorbent assay was used measure CXCL7 in 560 samples from patients...
3586 Background: IBI351 (GFH925) is an irreversibly covalent inhibitor of KRAS G12C and has demonstrated promising anti-tumor activity with acceptable safety in advanced solid tumors. Here, we report a pooled analysis two phase I studies (NCT05005234, NCT05497336) evaluating the efficacy monotherapy for metastatic colorectal cancer (CRC) harboring mutation. Methods: Eligible CRC patients (pts) mutation were included. Pts received orally at dose levels 700mg once daily (QD), or 450/600/750mg...
Abstract Background We aimed to develop a clinical applicable nomogram predict overall survival (OS) for patients with curatively resected nonmetastatic colorectal cancer. Methods Records from retrospective cohort of 846 complete information were used construct the nomogram. The was validated in prospective 379 patients. performance evaluated concordance index (c‐index), time‐dependent receiver operating characteristic (ROC) curves, calibration plots, and decision curve analyses...
Capecitabine is an orally administered prodrug of 5-fluouracil (5-FU) and used in first-line treatment metastatic colorectal cancer. Studies have demonstrated that polymorphisms 5-FU related ADME genes are associated with the efficacy capecitabine. However, relationship between within microRNA precursors capecitabine still largely unknown. We detected six 274 colon cancer patients statistically analyzed association genotypes capecitabine-based chemotherapy. The mechanisms underlying effect...
Objective The purpose of this study was to evaluate the clinical value technetium-99m-red blood cell (99mTc-RBC) scintigraphy in diagnosis orbital cavernous hemangioma (OCH). Patients and methods Forty-one patients with pathologically confirmed mass, which 10 were OCH, underwent 99mTc-RBC study. scanning procedure included an initial perfusion phase, followed by early a delayed pool phase. All ultrasonography computed tomography (CT), 15 also MRI. Results OCH had no abnormal findings on...
Objective To evaluate the clinical efficacy and prognostic factors of limited-stage small cell lung cancer (LS-SCLC)treated with 125I radioactive seed implantation guided by CT combined systemic chemotherapy. Methods A total 128 patients were treated chemotherapy from Jun 2008 to 2012 in Tianjin Medical University Second Hospital.The χ2 test was used analyze influencing short-term efficacy. Survival rate calculated Kaplan-Meier method, single factor analysis performed Log-rank,...
Objective To identify the risk factors, level of exposure, and population distribution in high-risk stroke people groups with age over 40 years Hebei Dongli Districts Tianjin. To explore serum homocystenine (Hcy) its influencing factors. Methods A total 834 cases were accepted divided into A (40~49) , B (50~59) C (60~69) D (≥70) based on age. Data analyzed using ANOVA, Chi-square test, binary logistic regression. Results The Hcy values (12.25±4.54) (14.01±6.67) (15.76±8.88)...
Objective To investigate the role of 99Tcm-macroaggregated albumin (99Tcm-MAA)pulmonary perfusion imaging in evaluating thrombolytic therapy pulmonary embolism. Methods Date 54 patients with acut embolism diagnosed by 99Tcm-MAA combined radiography were analyzed retrospectively. Among them, was also performed one week after therapy. In some cases, three months Results The results normal all among 347 abnormal segments cases. 164 (47.3%) and 199 (57.4%) restored to 1 3 later(χ2=10.68,...