A5102009660- Gut microbiota and health
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- Oral health in cancer treatment
- Cancer therapeutics and mechanisms
- Urinary and Genital Oncology Studies
- Cancer Mechanisms and Therapy
- Clinical Nutrition and Gastroenterology
- Cancer-related gene regulation
- Urologic and reproductive health conditions
- Polyamine Metabolism and Applications
- Connective tissue disorders research
- Aldose Reductase and Taurine
Anhui University of Traditional Chinese Medicine
2025
Anhui Medical University
2025
Liuyang City Maternal and Child Health Hospital
2024
China Academy of Engineering Physics
2024
First Affiliated Hospital of Bengbu Medical College
2024
Hangzhou Cancer Hospital
2024
Zhejiang Cancer Hospital
2024
Chinese Academy of Sciences
2024
Shanghai University of Traditional Chinese Medicine
2023
Dalian Medical University
2019-2021
Background: Lung cancer has the highest incidence and mortality rate of any worldwide. Platinum-based combination chemotherapy is still standard treatment for advanced lung cancer. However, clinical efficacy this can be affected by its adverse reactions, especially gastrointestinal mucositis. The reactions often lead to delayed reduced medication. role played gut microbiome in becoming clearer, evidence suggests that regulation may affect response multiple types treatment. Methods: Sixty...
The serum ceruloplasmin assay is the most commonly used test for diagnosing Wilson's disease (WD). Despite utility of non-invasive tests WD, no such have been developed. Therefore, we aimed to identify a safe and determine factors associated with salivary ceruloplasmin. sample comprised 167 participants: 130 patients WD (experimental group) 37 individuals without (control group). Salivary ceruloplasmin's diagnostic performance was assessed using receiver operating characteristic curve...
Colorectal cancer (CRC) is one of the most common malignancies in world. Studies have demonstrated that single nucleotide polymorphisms (SNPs) microRNA genes (miRSNPs) are involved occurrence cancers. However, relationship between miRSNPs within terminal-loops precursors and development CRC still largely unknown. In this study, we found a miRSNP rs7911488 T>C terminal-loop pre-miR-1307 was significantly associated with CRC. The C allele more prevalent patients than healthy controls (P <...
Abstract Prenatal environmental stress damages fetal testicular development, leading to male infertility. However, the precise mechanisms underlying impact of gestational on development require further investigation. This study demonstrates that stressor cadmium exposure caused placental estradiol synthesis inhibition and dysplasia. Gestational supplementation restores dysplasia by stress‐induced inhibition. Analysis human placentae cadmium‐stimulated primary trophoblasts confirmed ER‐phagy...
Inflammatory bowel disease (IBD) is a type of chronic inflammatory disturbance that affects number individuals worldwide; the precise mechanism unclear and treatment frequently insufficient to maintain patients in remission. Saccharomyces boulardii thermophilic, non‑pathogenic yeast may be administered for prophylaxis variety diarrheal diseases. Recent clinical studies have demonstrated it role IBD; however, action unclear. The hypoxia‑inducible factors (HIFs) are ubiquitously expressed...
AT‑rich interaction domain 1A (ARID1A) and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit α (PIK3CA) serve important roles in the formation development of numerous malignancies including gastric cancer. Accumulating evidence has demonstrated that Epstein‑Barr virus (EBV) is a pathogenic associated with The present study aimed to investigate association between EBV infection, expression levels ARID1A PIK3CA EBER situ hybridization was performed detect infection....
To investigate the association of microRNA (miRNA) binding-site polymorphisms in drug transporter genes with efficacy 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy colorectal cancer (CRC), 6 were determined 432 CRC patients by using DNA sequencing method. The impacts on miRNA-mediated regulation gene expression evaluated methods including quantitative real-time PCR, western blotting, and luciferase reporter assays. effects miRNA intracellular concentration cytotoxicity 5-FU cells...
Abstract: 2IgB7‐H3 has recently been identified as a new member of the B7 family. Its expression at protein level remains largely unknown due to lack specific monoclonal antibody (mAb). To characterize 2IgB7‐H3, we newly generated two mouse antihuman mAbs (4H7 and 21D4). We found constitutive on series tumor cell lines. Furthermore, was examined monocyte‐derived dendritic cells (Mo‐DCs) DCs from CD34 + hematopoietic progenitor (HPC) by means mAb staining. The results showed that expressed...
Abstract Background Circulating tumor DNA (ctDNA) has potential as a specific, noninvasive, and cost‐effective new biomarker for patients with lung cancer. This study aimed to determine whether plasma ctDNA can be used predict treatment outcomes in Methods Pre‐ in‐treatment blood samples were collected from 14 cancer receiving chemotherapy. Based on next‐generation sequencing technology, we constructed unique molecular identifier (UMI) library performed targeted deep of 72 genes (15 000×)....
Asthma, characterized by persistent inflammation and increased sensitivity of the airway, is most common chronic condition among children. Novel, safe, reliable treatment strategies are focus current research on pediatric asthma. Amygdalin, mainly present in bitter almonds, has anti-inflammatory immunoregulatory potential, but its effect asthma remains uninvestigated. Here, impact amygdalin thymic stromal lymphopoietin (TSLP)-dendritic cell (DC)-OX40L axis was investigated. A BALB/c mouse...
Abstract Background Lung cancer has the highest mortality rate among malignant tumors, with non‐small cell lung (NSCLC) being most common type. As main component of human microflora, intestinal flora interacts body to affect immunity, metabolism, and formation diseases. Methods Forty‐five patients advanced NSCLC who received platinum‐containing dual‐drug chemotherapy were enrolled in a prospective exploratory cohort study. The was dynamically collected at baseline after two cycles....
Abstract Introduction Targeted therapies are based on specific gene alterations. Various specimen types have been used to determine alterations, however, no systemic comparisons yet made. Herein, we assessed alterations in selected cancer‐associated genes across varying sample sites lung cancer patients. Materials and Methods deep sequencing for 48 tumor‐related was applied 153 samples from 55 patients obtained six sources: Formalin‐fixed paraffin‐embedded (FFPE) tumor tissues, pleural...
ABSTRACT Lung cancer is the leading cause of death. Better understanding factors and pathways involved in lung needed to improve diagnose treatment strategies. Recent studies have provided insights into possible correlation between intestinal dysbiosis development. Although immunological relationship gut had been suggested by many researches, however, date, no study investigated characterization microbiome naïve patients, whether it distinct from that health individuals contribute onset...
Objective: To analyze the clinical features and to explore etiology of short fetal femur during third trimester. Methods: From January 2010 June 2016, 21 singleton pregnancies with detected by ultrasonography trimester were referred Chinese PLA General Hospital. Clinical data collected, karyotype or single nucleotide polymorphism microarray was carried out detect chromosomal abnormalities, FGFR3 c.1138G>A mutation detection achondroplasia (ACH) via invasive procedure, respectively. The...