A5100350918- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Air Quality and Health Impacts
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Central Venous Catheters and Hemodialysis
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Occupational and environmental lung diseases
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diabetic Foot Ulcer Assessment and Management
- Nuclear Receptors and Signaling
- Metastasis and carcinoma case studies
- Protease and Inhibitor Mechanisms
- RNA Interference and Gene Delivery
- Iron Metabolism and Disorders
- Renal and Vascular Pathologies
- Atherosclerosis and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Healthcare Systems and Public Health
Guangdong Medical College
2025
Renji Hospital
2013-2024
Yangzhou University
2024
National Institute for Occupational Health and Poison Control
2014-2024
Shanghai Jiao Tong University
2014-2024
Guiyang Medical University
2023
Affiliated Hospital of Guizhou Medical University
2023
First People’s Hospital of Zunyi
2022
Zunyi Medical University
2022
Takeda (United States)
2022
Endothelial nitric oxide synthase (eNOS) is a multifunctional enzyme with roles in diverse cellular processes including angiogenesis, tissue remodeling, and the maintenance of vascular tone. Monomeric dimeric forms eNOS exist various tissues. The form considered active monomeric inactive. activity also regulated by many other mechanisms, amino acid phosphorylation interactions proteins. However, precise mechanisms regulating dimerization, phosphorylation, remain incompletely characterized....
The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) are 2 markers of inflammation, which associated with worse cardiovascular disease outcomes. Here, we aimed to determine the association between these ratios severity evaluate predictive validity NLR PLR in lower limb arteriosclerosis obliterans (ASO).We evaluated 211 patients a diagnosis ASO from January 2016 December 2018 at Shanghai Jiaotong University Renji Hospital. were accessed routinely drawn peripheral venous blood...
Objective This study aimed to understand the noise exposure of non-coal mines in China take appropriate controls protect workers' health. Methods An assessment miners' exposures was conducted four provinces China. Individual levels were measured, and survey on hearing protector device (HPD) equipment administered. Results 423 dosimeter measurements obtained, including drilling, blasting, ore drawing, transportation, winching, crushing, screening ball milling, auxiliary (air pressure, pump,...
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects ~2% of population aged ≥65 years. The degeneration dopamine neurons in substantia nigra contributes to pathogenesis PD. Dopamine receptor D2 (DRD2) and D3 (DRD3) are two key subtypes receptors. aim our study was evaluate association between polymorphisms DRD2 DRD3 genes Meta-analyses were conducted from 16 studies (46 stages) among 4,279 cases 5,661 controls PD 9 (DRD2: rs1800497, rs1079597, rs6278,...
Previous genome-wide association studies (GWAS) have revealed seven single nucleotide polymorphisms (SNPs) that affect lipoprotein-associated phospholipase A2 (Lp-PLA2) activity or levels in American and European individuals. A total of 290 coronary heart disease (CHD) patients, 198 non-CHD patients 331 unrelated healthy volunteers were recruited for the present case-control study Han Chinese. Four SNPs (rs964184 ZNF259, rs7528419 CELSR2 rs7756935 rs1805017 PLA2G7) shown to be significantly...
Abstract Background Vascular smooth muscle cells (VSMC) switch to macrophage‐like after cholesterol loading, and this change may play an important role in atherogenesis. Muscleblind‐like splicing regulator 1 (MBNL1) is a well‐known factor that has been implicated many cellular processes. However, the of MBNL1 VSMC transdifferentiation largely unknown. In study, we aim characterize MBNL1‐induced gene during Methods The expression Abelson interactor (Abi1) splice variants (Abi1‐e10 Abi1‐Δe10)...
Phenotypic switch of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis atherosclerosis. The mRNA expression synthetic biomarker Collagen Type I Alpha 1 Chain (COL1A1) gene is upregulated during VSMCs from contractile to phenotype. association noncoding circular RNAs transcribed by COL1A1 with VSMC phenotype alteration and atherogenesis remains unclear. Here we reported a RNA (circCOL1A1) which specifically expressed VSMCs. CircCOL1A1 also detectable serum or...
This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam intramuscular haloperidol for treatment acute agitation patients schizophrenia, explored possibility decreasing an 6-week by switching injection to RIS-OS. Two hundred five agitation-exhibiting schizophrenic inpatients at six hospitals were originally included study. The 47-day trial consisted 5 days (session I) receiving either (RIS-OS plus...
This study was conducted to retrospectively analyze the clinical characteristics of CTD-ILD patients provide strategies for management.This collected and analyzed data relevant examination results 161 diagnosed with between 01 January 2018 2021.A total patients, 74.53% were females 25.47% males, 32.92% elderly 67.08% non-elderly. The main symptoms cough (44.72%), decreased activity tolerance (40.37%). RA-ILD most common one in non-elderly (48.15% 50.94%, respectively). Compared non-elderly,...
Objective. This study aimed to investigate the angiographic manifestations of lower extremity atherosclerotic steno-occlusive disease in patients with diabetes. Materials and Methods. A total 162 diabetes were enrolled this study. The findings arterial lesions evaluated according location (iliac, femoral, popliteal, crural artery), type (stenosis or occlusion), length (<5 cm, 5-10 >5 cm). Results. 131 (80.9%) diabetics showed multiple segmental lesions, 19.1% (31/162) presented single...
Westaway et al. have revealed a significant association between common variants of calsequestrin-2 (CASQ2) and nitric oxide synthase 1 (neuronal) adaptor protein (NOS1AP) the risk sudden death in patients coronary heart disease (CHD). In light findings, we aim to explore two genes CHD Han Chinese. Our results show contribution rs10918859 NOS1AP gene Chinese (genotype: χ(2)=8.33, df=2, p=0.015; allele: χ(2)=4.00, df=1, p=0.047, odds ratio [OR]=1.44, 95% confidence interval [CI]=1.00-2.05)....
BACKGROUND Vascular complications are a major concern for patients with diabetes. Endothelial cells (ECs) play key role in vascular function. MicroRNAs (miRNAs) have been shown to an important mediating EC function; miRNAs vulnerable hyperglycemic conditions. Previous reports verified that Fas apoptotic inhibitory molecule 2 (FAIM2) can inhibit cell apoptosis through repressing the FAS-associated death domain protein (FADD) pathway. This current study was designed explore potential...