A5102913993- Spaceflight effects on biology
- High Altitude and Hypoxia
- Thermoregulation and physiological responses
- MicroRNA in disease regulation
- Human-Automation Interaction and Safety
- Muscle metabolism and nutrition
- Immune cells in cancer
- Medical and Biological Ozone Research
- Cardiovascular and Diving-Related Complications
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- HIV-related health complications and treatments
- Medical Research and Treatments
- HIV/AIDS drug development and treatment
- Space Exploration and Technology
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Peripheral Neuropathies and Disorders
- Craniofacial Disorders and Treatments
- Acute Myeloid Leukemia Research
- Hydrogen's biological and therapeutic effects
- Digital Transformation in Industry
- Chemokine receptors and signaling
- Sleep and Work-Related Fatigue
- Psoriasis: Treatment and Pathogenesis
People’s Hospital of Rizhao
2025
Renji Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Jinan University
2024
Dongguan University of Technology
2023-2024
Second Military Medical University
2023
Zhengzhou University
2020-2023
Sun Yat-sen University
2021
Shanghai Advanced Research Institute
2013
Air Force Medical University
2002-2012
MPT64 is one of the secreted proteins from Mycobacterium tuberculosis. Little known about its role in infection by In this study, we demonstrated that could dose-dependently inhibit apoptosis RAW264.7 macrophages induced PPD-BCG. Quantitative real-time PCR results showed expression bcl-2 increased treated with compared PPD-treated cells. Furthermore, provided strong evidence up-regulation was positively controlled miRNA-21. Finally, NF-κB identified as transcription factor for miRNA-21 using...
Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with poor patient prognosis. Current treatment for ESCC, including immunotherapy, only beneficial small subset of patients. Better characterization the tumor microenvironment (TME) and development novel therapeutic targets are urgently needed.In present study, we hypothesized that integration single-cell transcriptomic sequencing large microarray ESCC biopsies would reveal key subtypes determine prognostic...
Most cancers contain abundant tumor-associated macrophages (TAMs). TAMs usually display a tumor-supportive M2-like phenotype; they promote tumor growth and influence lymphocyte infiltration, leading to immunosuppression. These properties have made an attractive cancer immunotherapy target. One promising immunotherapeutic strategy involves switching the tumor-promoting immune suppressive microenvironment by reprogramming TAMs. However, clinical trials of macrophage yielded unsatisfactory...
Tryptophan 2,3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to kynurenine (KYN), which plays a critical role in mediating immune escape of cancer. Although accumulating evidence demonstrates that TDO2 overexpression implicated the development and progression multiple cancers, its tumor-promoting esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we observed was overexpressed ESCC tissues correlated significantly with lymph node metastasis, advanced clinical...
BACKGROUND: Meningocele results from a defect in the skull base bone, causing meningeal prolapse. Clinical manifestations of meningocele are often nonspecific and prone to misdiagnosis. Inadequate treatment may lead severe complications, including cerebrospinal fluid leakage, meningitis, or, rare cases, epilepsy, thereby posing significant risks patients involved aerospace operations. Historically, cases have predominantly been reported fetuses infants, with limited analysis documentation...
Significance Multiple sclerosis (MS) is a complex neuroinflammatory disorder that constitutes the major cause of nontraumatic disability in young adults. However, underlying mechanism this disease remains obscure. Here, we identified NMI and IFP35 as factors critical progress MS experimental autoimmune encephalomyelitis, their dysregulation activates both microglia central nervous system T cells periphery. This study expands our understanding pathogenesis aims to provide potential diagnostic...
Phenotypic switch of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis atherosclerosis. The mRNA expression synthetic biomarker Collagen Type I Alpha 1 Chain (COL1A1) gene is upregulated during VSMCs from contractile to phenotype. association noncoding circular RNAs transcribed by COL1A1 with VSMC phenotype alteration and atherogenesis remains unclear. Here we reported a RNA (circCOL1A1) which specifically expressed VSMCs. CircCOL1A1 also detectable serum or...
Robotic arms for industrial applications rely on expensive, complex solutions high-precision positioning error compensation. Digital twins (DTs) provide virtual representations of physical assets to optimize their engineering performance, which helps address the above issues. To this problem, article proposes a DT-driven 3-D position information mutuality and compensation robotic arm. A DT model is developed sensor modeled geometrically. Information exchange between enables comparison actual...
Abstract Predicting weak and hidden faults in unmanned aerial vehicles (UAVs) is challenging due to their variable operation conditions complex mechanisms. Conventional neural network models process the multisensory data form of Euclidean structure, intrinsic connections among individual points are easy be disregarded. Additionally, always directly fed into model without adequately considering importance or contribution each sensor. Hence, an UAV fault prediction method proposed by combining...
To assess the relationship between mean efavirenz (EFV) plasma concentration and clinical effect during first 48 weeks of combination antiretroviral therapy (cART), baseline CD4 cell count was recorded EFV were measured every 12 weeks. HIV-RNA viral load determined in 48th week cART. In total, 42 subjects recruited grouped according to their study period: groups A, B C with concentrations (mean) <2 mg/L (1.8 mg/L), 2-4 (2.9 mg/L) >4 (5.5 respectively. The counts group increased more quickly...
Summary There is evidence to suggest that microgravity/weightlessness can induce changes in lung physiology/function. We hypothesized microgravity, induced by head‐down bed rest ( HDBR ), would function and exercise training with artificial gravity AG ) prevent these from occurring. Twelve participants were randomly assigned a control or countermeasure CM group n = 6 per group) 96 h of 6° . Participants the exposed (alternating 2 min intervals +1·0 +2·0 G) for 30 min, twice daily, during...
Neutrophils are essential components of the innate immune system, playing a pivotal role in responses. These cells rapidly migrate to sites inflammation or tissue injury, facilitating pathogen clearance and repair. The chemotactic signaling network regulating neutrophil recruitment is complex not fully understood, particularly regarding damage-associated molecular patterns (DAMPs). In our previous research, we identified NMI as DAMP that activates dendritic macrophages, amplifying...
Abstract As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme anticipation of fourth one. We here present that could clear SARS-CoV-2 2-4 days post infection from upper respiratory tract (URT), where virions are initially concentrated. The scheme, applicable large scale by nasal spray, based on Homo-harringtonine (HHT) has been approved for treating other diseases. HHT blocked protein elongation and repressed vitro replication all 4...