A5100646467- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Mycobacterium research and diagnosis
- Cancer, Lipids, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Ubiquitin and proteasome pathways
- ATP Synthase and ATPases Research
- Biochemical Acid Research Studies
- Diet, Metabolism, and Disease
- Down syndrome and intellectual disability research
- Proteoglycans and glycosaminoglycans research
- Wnt/β-catenin signaling in development and cancer
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Advanced Glycation End Products research
- Apelin-related biomedical research
- Neuroendocrine regulation and behavior
- Fetal and Pediatric Neurological Disorders
Health Biomed (China)
2025
Ningbo University
2015-2024
Fujian Medical University
2024
Union Hospital
2024
Maastricht University
2023
Ningbo Medical Center Lihuili Hospital
2012-2015
Peking University People's Hospital
2015
Peking University
2015
Kumamoto University
2011
Some long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous (ceRNAs). However, lncRNA associated-ceRNAs oncogenesis are not fully understood. Here, based on microarray data gastric cancer, bioinformatic algorithm miRcode and microRNA (miRNA) targets database TarBase, we first constructed an lncRNA-miRNA-mRNA network. Then, confirmed it six types other cancer including head neck squamous cell carcinoma, prostate papillary...
Abstract Background Long non-coding RNAs (lncRNAs) are prevalently transcribed in the genome yet their potential roles human cancers not well understood. The aim of present study was to determine lncRNA expression profile gastric cancer and its clinical value. Methods global measured by microarray. Levels two representative lncRNAs, H19 uc001lsz, were confirmed real-time reverse transcriptase-polymerase chain reaction. relationship between levels clinicopathological factors patients with...
Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide. Innovative diagnostic biomarkers are a pressing need for this disease. miRNAs profiling an innovative method identifying many diseases could be proven as powerful tool in diagnosis treatment CAD. We performed miRNA microarray analysis from plasma three CAD patients healthy controls. Subsequently, we quantitative real-time PCR (qRT-PCR) expression another 67 identified two (miR-206 miR-574-5p) that...
Diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC). Hyperglycemia, a chronic abnormality in diabetes, independent predictor cancer-associated mortality CRC. However, the underlying biological mechanism hyperglycemia CRC cells largely unknown. In present study, HCT-116 and HT-29 cell proliferation, apoptosis, migration invasion were assessed. addition, expression epithelial (E)-cadherin, vimentin high-mobility group A protein 2 (HMGA2) assessed using...
Long non-coding RNAs (lncRNAs) play an important role in cancer occurrence and development. We previously demonstrated that lncRNA gastric cancer-associated transcript 3 (GACAT3) was positively correlated with TNM stages, tumor size, distant metastasis of patients cancer. However, the GACAT3 remains unclear. In this study, to investigate its function, we synthesized small interference (siRNAs) against GACTA3 developed a overexpression vector (pcDNA3-GACAT3), respectively. The siRNA-mediated...
How β-catenin/COX-2 contribute to inflammation-induced fibroblasts migration remains poorly understood. Therefore, in this study, lipopolysaccharide (LPS) was used as a stimulus accelerate the of NIH3T3 cells, which mimicked tissue repair process. LPS treatment increased cell concentration-and time-dependent manner. And NS398, COX-2 inhibitor, inhibited LPS-induced cells migration. DKK-1, an antagonist Wnt/β-catenin signaling, also that However, TWS119, inducer β-catenin via GSK-3β, or...
Colorectal cancer is a common malignant tumor of the gastrointestinal tract. Currently, main treatment surgical resection, which can be combined with other treatments. However, efficacy poor, and colorectal prone to relapse metastasis; thus, identifying an effective anti‑cancer drug urgent requirement. The present study examined antagonistic effect penicillin on cultured cells related mechanism. A MTT assay was used assess growth treated determine optimal concentration. wound healing...
Long noncoding RNAs (lncRNAs) play important roles in almost every stage of cancer development. Given the competing endogenous RNA (ceRNA) hypothesis for regulation gene expression, we investigated role LINC00152 as a ceRNA gastric (GC) cells.Gastric cell lines were used this study. Mimics miRNAs and siRNA to evaluate interaction between HMGA1. The quantitative real-time polymerase chain reaction was performed analyzing expression at transcriptional level. Flow cytometry assay cycle western...
Oxytocin (OXT) is proposed as a potential therapeutic peptide for social dysfunction due to its modulatory actions on socioemotional regulation in humans. While the majority of studies have used intranasal OXT administration, we recently shown that oral (lingual spray), but not intranasal, administration can significantly enhance activity brain reward system response emotional faces males; however, effects females are unknown.Seventy healthy participated current randomized,...
Westaway et al. have revealed a significant association between common variants of calsequestrin-2 (CASQ2) and nitric oxide synthase 1 (neuronal) adaptor protein (NOS1AP) the risk sudden death in patients coronary heart disease (CHD). In light findings, we aim to explore two genes CHD Han Chinese. Our results show contribution rs10918859 NOS1AP gene Chinese (genotype: χ(2)=8.33, df=2, p=0.015; allele: χ(2)=4.00, df=1, p=0.047, odds ratio [OR]=1.44, 95% confidence interval [CI]=1.00-2.05)....
High-mobility group A1 (Hmga1) protein is an architectural chromatin factor, and aberrant Hmga1 expression in mice causes hematopoietic malignancies with defects cellular differentiation. However, the functional involvement of development leukemic cells remains to be elucidated. Using Hmga1-green fluorescent (GFP) knock-in that endogenously express Hmga1-GFP fusion protein, we examined undifferentiated differentiated populations cells. During early T cell thymus, highly expressed...
Abstract Background Long non‐coding RNAs (lncRNAs) perform pivotal regulatory roles in tumor development. Our previous work revealed that the lncRNA gastric cancer‐associated transcript 3 ( GACAT3 ) was significantly overexpressed and associated with size metastasis cancer. Methods Total were extracted from colorectal cancer (CRC) reverse transcribed, then quantitative real‐time PCR (qRT‐PCR) conducted. Cell counting performed to assess effect of on CRC cell line proliferation....
Presbycusis affects approximately one-third of people over the age 65 and is a worldwide health problem. In current study, whether methylation level solute carrier family 26 member 4 (SLC26A4) predicted an increased risk presbycusis was investigated. Peripheral blood samples from 102 patients with 104 controls were collected, CpG sites SLC26A4 measured by applying pyrosequencing technology combined sodium bisulfate DNA conversion chemistry. Within promoter region, one site (CpG3) exhibited...
Abstract Objectives Metabolic syndrome (MS) is the concurrence of at least three five medical conditions: obesity, high blood pressure, insulin resistance, serum triglyceride (TG) and low high-density lipoprotein levels. While fibrates are used to treat disorders other than lowering TG, mechanism by which decrease MS has not been established. Methods In this study, wild-type Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil fenofibrate for 3 months respectively,...
The aim of this study was to explore the lncRNAs expression in colorectal cancer (CRC) patients with type 2 diabetes (T2DM) and evaluate diagnostic value CRC T2DM. present conducted on two cohorts patients. tissues levels were measured by real-time PCR analysis. results showed that H19 MALAT1 higher than normal mucosa (p = 1.59 × 10−6 p 6.95 10−9, respectively), whereas lincRNA-p21 lower 1.10 10−4). Logistic regression analysis indicated significantly T2DM compared without .032). group...
Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 (LGALS2) is involved in cytokine lymphotoxin-α (LTA) cascade that may influence progress CAD. The aim present study was to assess association between LGALS2 3279C>T (rs7291467) polymorphism and A total 562 cases 572 controls were recruited examine association. systematic meta-analysis performed evaluate contribution risk CAD among 12,093 11,020 controls. There no significant...
Long noncoding RNA (lncRNA) has been verified to interact with other biomolecules especially protein-coding genes (PCGs), thus playing essential regulatory roles in life activities and disease development. However, the inner mechanisms of most lncRNA-PCG relationships are still unclear. Our study investigated characteristics true constructed a novel predictor machine learning algorithms.We obtained 307 pairs from database found that there significant differences multiple between random sets....