A5040235944- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Ion channel regulation and function
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Folate and B Vitamins Research
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Neuroscience and Neural Engineering
- Metastasis and carcinoma case studies
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Immune Response and Inflammation
- Cancer-related gene regulation
Ningbo University
2012-2023
Ningbo Medical Center Lihuili Hospital
2012-2023
Air Force Medical University
2016-2019
Xijing Hospital
2016-2019
Sidney Kimmel Cancer Center
2016
Thomas Jefferson University
2016
Ningbo University Affiliated Hospital
2012-2014
To investigate the association of ABCG1, GALNT2 and HMGCR genes promoter DNA methylation with coronary heart disease (CHD) explore interaction between their status CHD patients' clinical characteristics in Han Chinese population.Methylation-specific polymerase chain reaction (MSP) technology was used to examine role aberrant gene population. A total 85 patients 54 participants without confirmed by angiography were recruited. 82.8% ABCG1 hypermethylation have CHD, while only 17.4% it. The...
Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide. Innovative diagnostic biomarkers are a pressing need for this disease. miRNAs profiling an innovative method identifying many diseases could be proven as powerful tool in diagnosis treatment CAD. We performed miRNA microarray analysis from plasma three CAD patients healthy controls. Subsequently, we quantitative real-time PCR (qRT-PCR) expression another 67 identified two (miR-206 miR-574-5p) that...
The human ether-a-go-go-related gene (hERG) is the major molecular component of rapidly activating delayed rectifier K+ current (Ikr ). Impairment hERG function believed to be a mechanism causing long-QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation pathway. purpose this study was screen and validate miRNAs regulate identified will provide new tools assess LQTS.Six were selected by algorithm predictions based on potential...
Lipoprotein(a) (Lp(a)) is associated with the severity of coronary lesions evaluated using Syntax score in patients stable artery disease (CAD). However, effect low-density lipoprotein cholesterol (LDL-C) levels on association Lp(a) remains unclear.A total 646 CAD were enrolled present study. measured an AU5800 Chemistry Analyzer. scores calculated by two advanced interventional cardiologists. SPSS 22.0 was used for statistical analyses.The concentration ranged from 1 to 192 mg/dL. Pearson's...
Background Observational studies have suggested that irritability is associated with a higher risk of cardiovascular disease (CVD). However, the potential causal association not clear. Therefore, we used Mendelian randomization (MR) analysis to assess CVD risk. Methods A two-sample MR was performed confirm several common CVDs. The exposure data were derived from UK biobank involving 90,282 cases and 232,386 controls, outcome collected published genome-wide (GWAS) FinnGen database....
Objective . Previous studies have confirmed that GCKR rs780093 polymorphism is associated with triglyceride (TG), a known risk factor of coronary heart disease (CHD). The goal our study to explore the association CHD in Han Chinese population. Methods and Results A total 568 cases 494 non-CHD controls were enrolled current case-control study. Genotyping was done using melting temperature shift (Tm-shift) approach. Our results also showed significantly TG level (<mml:math...
Background Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in also result potent blockade HERG current, negating their therapeutic benefit. It reported that PD-118057 and thapsigargin without hERG channel blockade, but the precise mechanism action unknown. Furthermore, effect on dominant negative E637K-hERG mutant has not been previously investigated. Objective In this study, we investigated: (a) current amplitudes WT-hERG...
Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 (LGALS2) is involved in cytokine lymphotoxin-α (LTA) cascade that may influence progress CAD. The aim present study was to assess association between LGALS2 3279C>T (rs7291467) polymorphism and A total 562 cases 572 controls were recruited examine association. systematic meta-analysis performed evaluate contribution risk CAD among 12,093 11,020 controls. There no significant...
Long QT syndrome type 2 is caused by a mutation in the human‑ether‑a‑go‑go‑related gene (HERG) encoding rapidly activating delayed rectifier K‑current. HERG key cell membrane glycoprotein; however, whether maturation process of protein involves molecules derived from calnexin (CNX)/calreticulin (CRT) cycle and how these work remains unknown. Using western blotting, present study screened CNX/CRT/endoplasmic reticulum 57 (ERP57) involved this cycle, it was revealed that expression levels...
Objective: To explore the expression and significance of CD28, ctla-4, CD80 CD86 in ankylosing spondylitis. Methods: Flow cytometry was used to test January 2016-January 2017 our hospital 73 cases spondylitis patients 40 normal controls CTLA 4, weeks outside lymphocytes. By ELISA method, lgA serum immunoglobulin IgG, IgM hypersensitive c-reactive protein (hs CRP) blood sedimentation (ESR) levels, explore, CD80, - age, duration hs CRP, ESR, Bath AS functional index (BASFI) measurement (BASMI)...