A5064235508- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Liver Disease and Transplantation
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
Second Affiliated Hospital of Nanjing Medical University
2025
Nanjing University
2025
Nanjing General Hospital of Nanjing Military Command
2025
Chinese PLA General Hospital
2014-2024
Qiqihar Medical University
2024
Nankai University
2022-2024
Shandong First Medical University
2024
PLA Academy of Military Science
2022
Hainan Branch of People's Liberation Army General Hospital
2022
People's Liberation Army No. 150 Hospital
2017-2019
Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks cancer. However, role splicing factor in metabolism and development remains poorly defined. Here, we show that upon intake, SRSF5 specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. promotes alternative CCAR1 to produce CCAR1S proteins, promote growth by enhancing consumption acetyl-CoA production. Conversely,...
Colorectal cancer (CRC), has a link between obesity, especially visceral fat. The body roundness index (BRI) can more accurately assess fat and levels. It is, however, unknown whether BRI is associated with CRC risk.53,766 participants were enrolled from the National Health Nutrition Examination Survey (NHANES). Analysing corelation risk was performed using logistic regression. Stratified analyses revealed association based on population type. Receiver operating characteristic curve (ROC)...
MicroRNAs are small non-coding RNA molecules that control expression of target genes. Previous studies showed microRNA-107 (miR-107) is overexpressed in gastric cancer tissues compared with the matched normal tissues. However, it remains largely unclear as to how miR-107 exerts its function and modulates malignant phenotypes cancer, because our understanding signalling pathways limited. In this study, we demonstrate frequently up-regulated cancers overexpression significantly associated...
Transforming growth factor (TGF)-β/Smad signaling plays an important role in colon cancer development, progression and metastasis. In this study we demonstrated that the microRNA-130a/301a/454 family is up-regulated tissues compared to paired adjacent normal mucosa, which share same 3′-untranslational region (3′-UTR) binding seed sequence are predicated target Smad4. colorectal HCT116 SW480 cells, overexpression of miRNA-130a/301a/454 mimics enhances cell proliferation migration, while...
Abstract Matrix metalloproteinase‐9 is a member of the metalloproteinases (MMP) family, which overexpressed in some solid tumor and thought to enhance invasion metastasis ability. Our study investigate association MMP‐9 expression with disease‐free survival overall patients gastric cancer. Clinical cancer specimens adjacent normal tissues from 286 who had not received neoadjuvant chemotherapy were investigated by immunohistochemistry assay. Staining evaluation results analyzed statistically...
Hepatocellular carcinoma is the fifth most common malignancy and third leading cause of cancer-related death worldwide. Dysregulation HomeoboxD10 (HOXD10) was found to suppress or promote cancer progression in different types. The function regulation HOXD10 remain unclear human hepatocellular (HCC). Primary HCC samples (117), normal liver tissue (15), 13 cell lines (SNU182, SNU449, HBXF344, SMMC7721, Huh7, HepG2, LM3, PLC/PRF/5, BEL7402, SNU387, SNU475, QGY7703, Huh1) were included this...
The objective of this study is to investigate and compare the mental health status personnel stationed at high- low-altitude bases provide a reference for future targeted education support initiatives. A total 1,244 posted in both were randomly selected using cluster sampling method. Basic details collected demographic information questionnaire, their was assessed Symptom Checklist-90 (SCL-90). Statistical analyses included t-tests Mann-Whitney U-tests. Principal component analysis (PCA)...
The shortening of telomeres may result in chromosome instability and thus promote tumorigenesis. Previous studies have demonstrated clear involvement telomere the carcinogenesis several malignancies. However, association between constitutive gastric cancer development has yet to be established. Therefore, present study, we measured average length using quantitative real-time PCR peripheral blood lymphocytes from a (GC) case-control study consisting 396 cases 378 controls. results showed that...
Increasing studies have confirmed long non-coding RNAs (lncRNAs) as novel regulators in tumorigenesis. LncRNA DDX11 antisense RNA 1 (DDX11-AS1) has been found to be abnormally expressed several tumors. In this work, we aimed evaluate its expressions and functions colorectal cancer (CRC).The Cancer Genome Atlas (TCGA) datasets were used for the identification of dysregulated lncRNA CRC. The levels DDX11-AS1 determined tumor tissues cell lines by Real Time-Polymerase Chain Reaction (RT-PCR)....
The S100 protein family comprises 22 members whose sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number cellular processes such as cell cycle progression and differentiation. However, expression status gastric cancer was not known yet. Combined with analysis series gene expression, virtual Northern blot microarray data, levels normal malignant stomach tissues systematically investigated. S100A3 further evaluated by quantitative RT-PCR....
We have investigated the expression and role of 58-kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry immunofluorescence, we observed MSP58 nucleus cytoplasm CRC cells, found to be present specimens more often than adjacent non-tumor tissues (92.5 vs 36.3%, P < 0.01). The average staining score was significantly lower (2.05 +/- 1.13 5.23 1.38, Moreover, mRNA appeared upregulated six fresh samples compared their non-cancerous tissues. also detected human...
Natural killer (NK) cells play important roles in the immune defense against tumor cells. The function of NK is determined by a balance between activating and inhibitory signals. DNAX accessory molecule-1 (DNAM-1) group 2 member D (NKG2D) are major cell receptors, which transduce signals after binding their ligands CD155, CD112 histocompatibility complex class I-related chains A B (MICA/B). However, expression functions these colon carcinoma still elusive. Here, we show higher MICA/B...
Angiogenesis plays a key role in the development and treatment response of various tumors. The signaling transductions mediated by binding vascular endothelial growth factor (VEGF) to its receptor KDR (kinase insert domain receptor) is most important pathway tumor angiogenesis. Single nucleotide polymorphisms (SNPs) VEGF have been extensively implicated etiology outcome colorectal cancer (CRC). However, no study has reported evaluating SNPs CRC prognosis. We herein assessed association...
Abstract Nedd8 is a ubiquitin-like protein that controls vital biological events through conjugation to target proteins. We previously identified the HECT-type ubiquitin ligase Smurf1 which diverse cellular processes activated by covalent neddylation. However, effect of non-covalent binding remains unknown. In this study, we demonstrate both and its homologue Smurf2 carry Nedd8-binding site within catalytic HECT domain. Structural analysis reveals has sites small sub-domain N-lobe C-lobe...