A5021377965- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Tumors and Oncological Cases
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pain Mechanisms and Treatments
- Vascular Malformations and Hemangiomas
- Lung Cancer Treatments and Mutations
- Network Time Synchronization Technologies
- Oral microbiology and periodontitis research
- Blood groups and transfusion
- Histiocytic Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Energy Efficient Wireless Sensor Networks
- COVID-19 epidemiological studies
- Nanoplatforms for cancer theranostics
- Oral and Craniofacial Lesions
- Neuropeptides and Animal Physiology
- Viral-associated cancers and disorders
- Fibroblast Growth Factor Research
Chinese People's Liberation Army
2025
Air Force Medical University
2015-2025
The University of Queensland
2023-2024
Kaohsiung Medical University
2015-2024
Beijing National Laboratory for Molecular Sciences
2024
Chinese Academy of Sciences
2009-2024
Institute of Chemistry
2024
Peking University
2022-2024
Peking University Sixth Hospital
2022-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2013-2023
Abstract The cell ecology and spatial niche implicated in the dynamic sequential process of lung adenocarcinoma (LUAD) from situ (AIS) to minimally invasive (MIA) subsequent (IAC) have not yet been elucidated. Here, we performed an integrative analysis single-cell RNA sequencing (scRNA-seq) transcriptomics (ST) characterize atlas invasion trajectory LUAD. We found that UBE2C + cancer subpopulation constantly increased during LUAD with remarkable elevation IAC, its distribution was peripheral...
It is generally accepted that the development of cancer in oral mucosa preceded by an identifiable non-invasive precursor lesion. The aim this follow-up study was to estimate rate and time transformation a group patients from southern Taiwan with potentially malignant epithelial lesions.The defined as duration between onset initial diagnosis occurrence confirmed cancer. A total 1458 histological diagnoses various pre-malignant lesions were followed up 1991 2001. average age at 47.5 years....
Oral cancers can be preceded by clinically evident oral potentially malignant disorders (OPMDs). The current study evaluated the rate and time of transformation in various OPMDs a cohort patients from southern Taiwan. Parameters possibly indicative for OPMDs, such as epidemiological etiological factors, clinical histopathological features were also described. We followed-up 5071 with OPMDs—epithelial dysplasia submucous fibrosis, epithelial hyperkeratosis/epithelial hyperplasia, lichen...
Although the use of removable dentures can improve oral function and esthetics for elderly people, compared to those who do not wear dentures, wearing could have worse health related-quality life (OHRQoL). Additional information is required assess which factors related denture influence OHRQoL individuals. The purpose this study evaluate association between in a sample individuals Taiwan. population included 277 people (mean age = 76.0 years). Using face-to-face interviews, we collected data...
Abstract Electrolyte additive is an effective strategy to inhibit the uncontrolled growth of Li dendrites for lithium metal batteries (LMBs). However, most additives are complex synthesis and prone decompose in cycling. Herein, order guide homogeneous deposition + , carbonized polymer dots (CPDs) as electrolyte successfully designed synthesized by microwave (M‐CPDs) hydrothermal (H‐CPDs) approaches. The controllable functional groups containing N or O (especially pyridinic‐ pyrrolic‐...
Structural properties of single lambda DNA treated with anti-cancer drug cisplatin were studied magnetic tweezers and AFM. Under the effect low-concentration cisplatin, became more flexible, persistence length decreased significantly from approximately 52 to 15 nm. At a high concentration, condensation phenomenon was observed. Based on experimental results both single-molecule AFM studies, we propose model explain this kind by cisplatin: first, di-adducts induce local distortions DNA. Next,...
Abstract People with intellectual disability have a higher risk of oral health problems. This study assessed the clinical status and behaviors treatment needs people living in an institution Padang, West Sumatra, Indonesia. We quantified 65 individuals using Oral Hygiene Index Simplified (OHIs), Angle’s classification malocclusion, Community Periodontal Treatment Need (CPITN), decay index also recorded their brushing behavior. found that males had significantly lower OHIs (p < 0.001),...
The prevention and precise treatment of early-stage lung adenocarcinoma (LUAD) characterized by small nodules (stage IA) remains a significant challenge for clinicians, which is due largely to the limited understanding oncogenic mechanisms spanning from preneoplasia invasive adenocarcinoma. Our study highlights pivotal role cancer cells exhibiting high expression centromere protein F (CENPF), driven TP53 mutations, become increasingly prevalent during transition LUAD. Biologically, (CENPF+)...
Objective: To investigate the association of urinary albumin-to-creatinine ratio (UACR) in normal range and cardiovascular health (CVH) score with cardio-cerebroascular all-cause mortality urban elderly residents Beijing. Methods: Based on Beijing Healthy Aging Cohort Study, data from 1 817 participants UACR were analyzed, was used as both continuous categorical variable. "Life's Essential 8" to develop a CVH score. Statistical analysis performed by using software SPSS 26.0 R 4.2.1,...
Objective: To describe and analyze the distribution characteristics of a body shape index (ABSI) its association with all-cause mortality in elderly communities Beijing. Methods: The baseline follow-up data 10 423 subjects Beijing Healthy Aging Cohort Study were used. endpoint outcome was follow-up. associations ABSI, BMI waist circumference analyzed Cox proportional hazard regression model. Results: mean time this cohort 6.36 years 15.27%. restricted cubic spline results showed that ABSI...
Objective: To study the association between subtypes of hypertension and risk for all-cause mortality cardio-cerebrovascular mortalities in elderly communities Beijing. Methods: The data were collected from Beijing Healthy Aging Cohort Study. 5 urban areas (former Xicheng, former Xuanwu, Fangshan, Haidian Tongzhou) 4 rural (Yanqing, Miyun, Huairou Daxing) selected as subjects by multi-stage stratified cluster random sampling. baseline survey was conducted July 2009 to September 2015....
Abstract Objective Mutations in driver genes contribute to the development and progression of lung adenocarcinoma (LUAD). However, dynamic evolutionary process from situ (AIS) minimally invasive (MIA) eventually (IAC), role is currently unclear. This study aimed analyse gene status LUAD preneoplasia IAC. Methods Patients with who underwent surgery our centre March 2015 December 2019 were retrospectively analysed, patients tumour sizes ≤3.0 cm pN0 included final analysis. The mutation common...
To determine the expressions of hypoxia-related [hypoxia-inducible transcription factors (HIF)-1α, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and phospho-adenosine monophosphate activated kinase (pAMPK)] autophagy-related [microtubule-associated 1 light chain (LC3), beclin-1 (BECN-1), gene (Atg)5-12, p62] proteins in human inflammatory periapical lesions.Fifteen samples radicular cysts (RCs) 21 granulomas (PGs), combined with 17 healthy dental pulp tissues, were...