Y. K. Chen

ORCID: 0000-0001-9152-6056
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About
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Research Areas
  • Animal Behavior and Reproduction
  • Glutathione Transferases and Polymorphisms
  • Amphibian and Reptile Biology
  • Tissue Engineering and Regenerative Medicine
  • Kruppel-like factors research
  • Nonmelanoma Skin Cancer Studies
  • Oral Health Pathology and Treatment
  • Metabolism, Diabetes, and Cancer
  • Oral and Maxillofacial Pathology
  • Electrospun Nanofibers in Biomedical Applications
  • Plant and animal studies
  • Histiocytic Disorders and Treatments
  • Skin and Cellular Biology Research
  • PI3K/AKT/mTOR signaling in cancer
  • Skin Protection and Aging
  • Mycotoxins in Agriculture and Food
  • Cervical Cancer and HPV Research
  • Photodynamic Therapy Research Studies
  • Physiological and biochemical adaptations
  • Infectious Diseases and Mycology
  • Autophagy in Disease and Therapy
  • Mesenchymal stem cell research
  • Carcinogens and Genotoxicity Assessment
  • Bone health and treatments

Kaohsiung Medical University
1989-2024

Kaohsiung Medical University Chung-Ho Memorial Hospital
2013-2017

To determine the expressions of hypoxia-related [hypoxia-inducible transcription factors (HIF)-1α, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) and phospho-adenosine monophosphate activated kinase (pAMPK)] autophagy-related [microtubule-associated 1 light chain (LC3), beclin-1 (BECN-1), gene (Atg)5-12, p62] proteins in human inflammatory periapical lesions.Fifteen samples radicular cysts (RCs) 21 granulomas (PGs), combined with 17 healthy dental pulp tissues, were...

10.1111/iej.12782 article EN International Endodontic Journal 2017-04-25

The expression and localization of glutathione S‐transferase (GST) isoenzymes in the epithelium normal oral mucosa ( n = 9), overlying reactive fibrous hyperplasia =9), potentially malignant [leukoplakia =25), submucous fibrosis =12), verrucous =16)] [squamous cell carcinoma =36), =13)] lesions were examined immunohistochemically using polyclonal antibodies raised against GST (alpha, mu pi) with standard avidin‐biotin‐peroxidase complex (ABC) method. alpha, pi almost completely absent benign...

10.1111/j.1600-0714.1995.tb01192.x article EN Journal of Oral Pathology and Medicine 1995-08-01

Reviewing the literature, hepatic differentiation of human dental pulp stem cells (hDPSCs) from cryopreserved tissues vital extracted teeth with disease has not been studied. This study is aimed to evaluate hypothesis that hDPSCs could possess potential differentiation. Forty recruited for isolation, cell characterization and were randomly equally divided into group A (liquid nitrogen-stored tissues) B (freshly derived tissues). Samples isolated groups but without growth factors formed...

10.1002/term.1763 article EN Journal of Tissue Engineering and Regenerative Medicine 2013-08-16

Abstract The hypothesis of slow–fast syndromes predicts a correlation between personality type and learning style; fast explorers would have more proactive (fast but inflexible) style whereas slow be reactive (slow flexible) learners. Empirical evidence for this personality-cognition coupling remains inconclusive heavily biased toward birds. Moreover, most studies did not examine the when cognitive task is discerning food quality, scenario directly related to energy acquisition that...

10.1093/beheco/arae065 article EN Behavioral Ecology 2024-08-13

The purpose of the present study was to determine minimal arecaidine concentrations showing a synergistic effect on DMBA‐induced hamster cheek pouch carcinogenesis. One hundred and twelve male adult Syrian golden hamsters were divided into 16 groups, each containing seven animals. After eight weeks DMBA initiation then four promotion. 100% tumor incidence found with 400 μg/ml 500 μg/ml; average numbers 1.86 ± 0.63 0.93 respectively ( P < 0.05). subsequent painting, all developed visible...

10.1111/j.1600-0714.1996.tb00194.x article EN Journal of Oral Pathology and Medicine 1996-02-01

The sequential changes of creatine kinase (CK) isoenzyme activity in serum and hamster buccal pouch tissue (HBPT) normal, premalignant, malignant stages during 13 wk DMBA induced squamous cell carcinogenesis, were studied. We found that the total CK both HBPT painted groups increased premalignant period (3‐7 wk), with peak being at 7 wk, while declining (9‐13 wk). No significant difference CK‐MM, CK‐MB CK‐BB activity, DMBA‐induced could be established. However, macro type 2 (MCK‐2), a...

10.1111/j.1600-0714.1991.tb00408.x article EN Journal of Oral Pathology and Medicine 1991-11-01

The aim of the present study was to investigate sequential expression placenta! glutathione S‐transferase (GST‐P) during 7, l2‐dimethylbenz[a]anthra‐cene (DMBA)‐induced hamster buccal pouch squamous cell carcinogenesis. Both immunohistochemical and immunoblot analyses were employed detect epithelial GST‐P in bamster mucosa over a 15‐week treatment regimen. No positivity demonstrated pouches control group. positive cells first noted as early 1 week after DMBA applications. A gradual increase...

10.1111/j.1600-0714.1996.tb00284.x article EN Journal of Oral Pathology and Medicine 1996-08-01

The pattern of keratin expression in hamster cheek pouch epithelium during 15‐wk DMBA‐induced carcinogenesis was studied. sequential changes Cytokeratins premalignant and malignant tissues comparative investigation normal epithelial were examined a weekly chemical carcinogenesis. Keratin polypeptides appear molecular weight range 43–67 kd 5–6 proteins can be identified. disappearance high (61–67 kd) observed from the 6‐wk DMBA‐treated group to group. An additional polypeptide noted initially...

10.1111/j.1600-0714.1989.tb00399.x article EN Journal of Oral Pathology and Medicine 1989-05-01

Abstract The hypothesis of slow-fast syndromes predicts a correspondence between personality type and learning style; fast explorers would have more proactive (fast but inflexible) style slow be reactive (slow flexible) learners. Empirical evidence for this personality-cognition coupling remains inconclusive heavily biased towards birds. Moreover, most studies did not examine the correlation when cognitive task is discerning food quality, scenario directly related to energy acquisition that...

10.1101/2024.03.26.586890 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2024-03-29
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