A5101494995- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Bone health and treatments
- Breast Lesions and Carcinomas
- Skin and Cellular Biology Research
- Oral Health Pathology and Treatment
- Breast Cancer Treatment Studies
- Ultrasound Imaging and Elastography
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Photodynamic Therapy Research Studies
- Skin Protection and Aging
- HER2/EGFR in Cancer Research
- dental development and anomalies
- Medicinal plant effects and applications
- Phytochemistry and Biological Activities
- Forensic Anthropology and Bioarchaeology Studies
- Pediatric Urology and Nephrology Studies
- Carcinogens and Genotoxicity Assessment
- Mycotoxins in Agriculture and Food
Gilead Sciences (United States)
2024
Union Hospital
1997-2019
Fujian Medical University
2006-2019
Hunan University of Traditional Chinese Medicine
2014
Beijing University of Chinese Medicine
2014
Kaohsiung Medical University
1989-2002
Rutgers, The State University of New Jersey
1994
University of Chicago
1987
For the first time, a selective and rapid ultra-performance liquid chromatography method with tandem mass spectrometric (UPLC-MS/MS) detection for simultaneous determination of typhaneoside isorhamnetin-3-O-neohesperidoside in rat plasma was developed validated, which applied to pharmacokinetic study Pollen Typhae extract. The separation carried out on an ACQUITY UPLC(TM) BEH C18 column gradient elution using mobile phase including acetonitrile water (containing 0.1% formic acid). flow rate...
The expression and localization of glutathione S‐transferase (GST) isoenzymes in the epithelium normal oral mucosa ( n = 9), overlying reactive fibrous hyperplasia =9), potentially malignant [leukoplakia =25), submucous fibrosis =12), verrucous =16)] [squamous cell carcinoma =36), =13)] lesions were examined immunohistochemically using polyclonal antibodies raised against GST (alpha, mu pi) with standard avidin‐biotin‐peroxidase complex (ABC) method. alpha, pi almost completely absent benign...
Mongoloid populations differ from Caucasoids by having a high prevalence of shovel trait and low Carabelli's trait. This study was conducted to investigate the effects on in population. The research design sought population that resides an isolated area exhibits admixture with neighboring populations. group selected for Bunun tribe aborigines who inhabit alpine Taiwan. sex age were controlled this investigation, as association between tooth size Results show males more likely have expressed...
The purpose of the present study was to determine minimal arecaidine concentrations showing a synergistic effect on DMBA‐induced hamster cheek pouch carcinogenesis. One hundred and twelve male adult Syrian golden hamsters were divided into 16 groups, each containing seven animals. After eight weeks DMBA initiation then four promotion. 100% tumor incidence found with 400 μg/ml 500 μg/ml; average numbers 1.86 ± 0.63 0.93 respectively ( P < 0.05). subsequent painting, all developed visible...
The sequential changes of creatine kinase (CK) isoenzyme activity in serum and hamster buccal pouch tissue (HBPT) normal, premalignant, malignant stages during 13 wk DMBA induced squamous cell carcinogenesis, were studied. We found that the total CK both HBPT painted groups increased premalignant period (3‐7 wk), with peak being at 7 wk, while declining (9‐13 wk). No significant difference CK‐MM, CK‐MB CK‐BB activity, DMBA‐induced could be established. However, macro type 2 (MCK‐2), a...
The aim of the present study was to investigate sequential expression placenta! glutathione S‐transferase (GST‐P) during 7, l2‐dimethylbenz[a]anthra‐cene (DMBA)‐induced hamster buccal pouch squamous cell carcinogenesis. Both immunohistochemical and immunoblot analyses were employed detect epithelial GST‐P in bamster mucosa over a 15‐week treatment regimen. No positivity demonstrated pouches control group. positive cells first noted as early 1 week after DMBA applications. A gradual increase...
Abstract This paper reports a case of adenomatoid hyperplasia minor salivary glands in the retromolar area, with unique symptom painful swelling. appears to be first reported Chinese population. It would useful for clinical dentists aware this tumour.
The pattern of keratin expression in hamster cheek pouch epithelium during 15‐wk DMBA‐induced carcinogenesis was studied. sequential changes Cytokeratins premalignant and malignant tissues comparative investigation normal epithelial were examined a weekly chemical carcinogenesis. Keratin polypeptides appear molecular weight range 43–67 kd 5–6 proteins can be identified. disappearance high (61–67 kd) observed from the 6‐wk DMBA‐treated group to group. An additional polypeptide noted initially...
Shuler CF, Mostofi R, Lin L‐M, Schwartz SA. Keratin protein identification in dimethylbenzanthracene‐induced hamster cheek‐pouch squamous cell carcinomas. J Oral Pathol Individual keratin proteins were identified 10 DMBA induced carcinomas (SCC) of the cheek pouch. SDS‐polyacrylamide gel electrophoresis water‐insoluble cytoskeletal extracts from tumor tissue demonstrated alterations distribution normal for site. Immunoblot analysis with a broad spectrum polyclonal antikeratin antiserum...
The Ganoderma, one of the prevalent Chinese medicinal mushrooms, is a multiple species colony genus Ganoderma belonging to polyporeceae 1 widely distributed in China.The two have officially been adopted Pharmacopoeia under same crude drug name Lingzhi constituting lucidum (leyss.ex Fr. ) Karst and G. sinense Zhao, Xu et Zhang 2 .Lingzhi has recognized by medical professions for treatment debility weakness, insomnia, hepatitis, cardiovascular diseases cancer [3][4] , etc. Up now, an abundant...
Supersonic shear imaging (SSI) is a relatively new technique to measure the elasticity of target tissues based on wave propagation. The aim this study was evaluate value SSI in discriminating nonfibrotic nonalcoholic steatohepatitis (NASH) from less severe fatty liver disease (NAFLD), NASH with fibrosis, and normal liver, as well relationship between various NAFLD pathologic or biochemical findings elasticity. Rabbits different degrees were subjected for measurement. Plasma collected...
Objective To investigate the value of ultrasonography in diagnosis and preoperative TNM staging for neuroendocrine breast cancer(NEBC). Methods The ultrasonic characteristics 12 NEBC 104 invasive ductal carcinoma(IDC) confirmed by pathology, as well metastatic lymph nodes were analyzed retrospectively. The TNM-staging was evaluated according to pathology. And relation between lesions size Ki-67 then analyzad. Results NEBC mainly showed solid heterogeneous hypoechoic(66.67%),...
Objective To investigate the ultrasound characteristics of microinvasive breast carcinoma(MBC), and to improve its detection rate. Methods Sixty-five MBC, 85 ductal carcinoma in situ(DCIS) 99 invasive carcinoma(IDC) confirmed by pathology were divided into mass type according ultrasonic manifestaions, retrospectively analyzed. Results MBC showed 89.23%(58/65) with 64 lesions 10.77%(7/65) type.DCIS 88.24%(75/85) 78 11.76%(10/85) type. IDC group all 102 lesions. In most solid...