A5102815074- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Kruppel-like factors research
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoparticle-Based Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Nanomaterials in Catalysis
- Circular RNAs in diseases
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Intraperitoneal and Appendiceal Malignancies
- Medical Imaging and Pathology Studies
- Chromatography in Natural Products
- Berberine and alkaloids research
- Pleural and Pulmonary Diseases
- Occupational and environmental lung diseases
- Ginseng Biological Effects and Applications
- Chronic Kidney Disease and Diabetes
Jilin University
2008-2025
Union Hospital
2006-2025
Union Hospital
2008-2024
Chinese University of Hong Kong
2024
Jilin Medical University
2012
Fujian Medical University
2006
Colorectal cancer (CRC), with its significant incidence and metastatic rates, profoundly affects human health. A common oncogenic event in CRC is the aberrant activation of Wnt/β-catenin signalling pathway, which drives both initiation progression disease. Persistent facilitates epithelial-mesenchymal transition (EMT), accelerates invasion metastasis. This review provides a summary recent molecular studies on role axis regulating EMT cells, triggers pathogenesis. We present comprehensive...
Gastric cancer is reported as one of the leading factors resulting in tumor-related death worldwide. However, therapies to suppress gastric are still limited and emergence drug resistance makes it necessary develop new effective anticancer drugs combinational chemotherapy schemes. Liquiritin (LIQ) a major constituent Glycyrrhiza Radix, exhibiting various pharmacological activities, including anticancer. In this study, we investigated role LIQ human cells with cisplatin (DDP) resistance. The...
Effects of preoperative one week enteral nutrition (EN) support on the postoperative nutritional status, immune function and inflammatory response gastric cancer patients were investigated.106 cases randomly divided into EN group (trial group) early (control group), which continuously treated with until 9th day according to different treatment protocols. All checked for their body weight, skinfold thickness, upper arm circumference, white blood cell count (WBC), albumin (ALB), prealbumin...
MiR-216a-5p has opposite effects on tumorigenesis and progression in the context of different tumors, acting as either a tumor suppressor or an oncogene. However, expression function miR-216a-5p pancreatic cancer (PC) is not well characterized. In this study, we found was significantly downregulated PC tissues cell lines, which showed negative correlation with peripancreatic lymph, perineural invasion TNM stage PCs patients. We made use functional assays to reveal that inhibited growth...
The expression of MiR-135b-5p was up-regulated while Krüppel-like factor 4 (KLF4) extremely low in human gastric carcinoma (GC) tissues. This study aimed to explore the role miR-135b-5p GC cells and its influence on various cell capacity viability by targeting KLF4.The dual-luciferase reporter assay first performed target relationship between KLF4 confirmed. Then three lines normal epithelial line (GES1) were analyzed for level mRNA RT-qPCR. BGC-823 chosen subsequent assays.The manipulated...
Colon cancer is one of the most lethal varieties cancer. Chemotherapy remains as principal treatment approaches for colon The anticancer activity procaine (PCA), which a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore effect PCA on and its underlying mechanism. results showed that significantly inhibited cell viability, increased percentage apoptotic cells, decreased expression level RhoA HCT116 cells dose-dependent manner (p < 0.05 or p...
<b><i>Background/Aims:</i></b> Endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells (GEnCs) can induce albuminuria in diabetic nephropathy. Melatonin attenuates nephropathy, but its role and mechanism EndMT GEnCs nephropathy remain unknown. <b><i>Methods:</i></b> The effect melatonin on induced by transforming growth factor (TGF)-β2 human renal was determined assaying the expression marker (VE-cadherin CD31) mesenchymal...
Imaging examinations exhibit a certain rate of missed detection for distant metastases gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). This study aims to develop and validate risk prediction model the prognosis GEP-NENs. included patients diagnosed with (GEP-NENs) from Surveillance, Epidemiology, End Results (SEER) database between 2010 2015. External validation was performed China-Japan Union Hospital Jilin University. Univariate multivariate logistic regression analyses were...
Background/Aims: The present study was aimed at examining Ezrin expression in human colorectal cancer (CRC) tissues and elucidating the influence of baicalein on proliferation HCT116 cells. Methods: determined by qRT-PCR immunohistochemistry. cells were divided into four groups－ groups with various concentrations, pcDNA3.1-Ezrin group, si-Ezrin group dual inhibitory (baicalein + si-Ezrin). CCK-8 assay flow cytometry (FCM) employed to assess cell detect distribution cycle respectively. levels...
Gastric cancer is the fourth most common type of and second highest leading cause cancer-related deaths worldwide. It has already been established that miR-133a involved in gastric cancer. In this study, we investigated molecular mechanisms by which inhibits proliferation cells. We analyzed proliferative capacity human cells SNU-1 using an MTT assay. Cell apoptosis was determined flow cytometry. The expression levels ERBB2, p-ERK1/2, p-AKT were Western blot analysis. To confirm ERBB2 a...
Melatonin exerts a range of physiological effects. However, the functional significance melatonin in spermatogenesis and underlying mechanisms remain unclear. MicroRNAs (miRNAs) are essential initiation progression testicular development, including spermatogenesis. Thus far, limited information is known about role miRNAs melatonin-mediated In this study, expression levels miRNA machinery genes, namely, Dgcr8and Xpo5,were significantly increased by melatonin. The profile was identified testes...
Recent reports suggest that colorectal carcinoma (CRC) may be sustained by a small subpopulation of cells, termed cancer stem cells (CSCs), which have drug resistance properties as key reason for chemotherapy failure. The epidermal growth factor receptor (EGFR) controls CRC initiation and progression. Monoclonal antibody against EGFR (cetuximab) has been used in treatment several cancers. However, the effects cetuximab on CSCs remain unclear. Here, we studied CSC-like Fluorouracil...
The use of combination therapies that employ a variety cell death mechanisms has emerged as promising avenue research in the treatment cancer. However, optimization therapeutic synergies when integrating different modes remains significant challenge. To this end, we developed multifunctional intelligent drug-carrying nanoparticle (DFMTCH NPs) based on metal-organic framework MIL-100, loaded with doxorubicin (DOX) and disulfiram (DSF), coated Cu-tannic acid (Cu-TA) network hyaluronic (HA),...