A5102712782- Liver Disease Diagnosis and Treatment
- Epilepsy research and treatment
- Lung Cancer Treatments and Mutations
- Hip and Femur Fractures
- Bone fractures and treatments
- Immunotherapy and Immune Responses
- Ion channel regulation and function
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Bone Metabolism and Diseases
- Oral Health Pathology and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Orthopaedic implants and arthroplasty
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Infectious Diseases and Mycology
- Lymphadenopathy Diagnosis and Analysis
- Cancer-related Molecular Pathways
- Bone health and osteoporosis research
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
Beijing Ditan Hospital
2013-2025
Capital Medical University
2015-2025
Union Hospital
2024-2025
Fudan University
2007-2025
Jilin University
2024-2025
Beijing Shijitan Hospital
2025
University of Pennsylvania
2024
Tsinghua University
2024
Henan Provincial People's Hospital
2022-2024
Huashan Hospital
2010-2023
Background and Aims: NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier 1 (MPC1) inflammation, fibrosis, insulin sensitivity in obese or NASH mouse models. However, impact of MPC1 on NAFLD-related liver lipid metabolism its role progression require further investigation. Approach Results: expression was measured tissues from normal controls patients with NAFLD. We characterized phenotypes genes...
Background: Studies on prognosis of different metastasis sites in patients with lung cancer are limited. The aim present study was to investigate the prognostic value metastases among metastatic cancer. Methods: Between 2010 and 2014, diagnosed were selected using Surveillance, Epidemiology, End Results (SEER) database. Kaplan-Meier methods adopted multivariable Cox regression models built compare sites. Results: A total 54,697 eligible identified, including 10,945 (20.0%) had isolated bone...
In a recent development, cohort of hepatologists has proposed altering the nomenclature non-alcoholic fatty liver disease (NAFLD) to metabolic-associated steatotic (MASLD), accompanied by modified diagnostic criteria. Our objective was investigate effect revised definition on identifying significant hepatic fibrosis.
Abstract Naringin maintains bone mass in various osteoporosis models, while its effect on disuse has not been reported. The present study explores whether naringin can prevent induced by unilateral sciatic neurectomy (USN) and the Semaphorin 3A-induced Wnt/β-catenin signalling pathway is involved osteoprotection of naringin. dose-dependently prevented deterioration mineral density (BMD), trabecular structure biomechanical strength femur due to USN. increased formation but inhibited...
The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. aim this study was to explore pathogenesis ONFH from a biomechanical standpoint provide theoretical basis for improved treatments. We compared bone structure fractured heads with that necrotic by Micro-CT scanning and histological evaluation. In addition, we properties each zone in those using tests. Compared heads, microarchitecture morphometry sclerotic have altered markedly. weaken markedly, while strengthen....
Small cell lung cancer (SCLC) is highly aggressive and prone to hypervascular metastases. Recently, we found profilin 2 (PFN2) expression in SCLC but not normal tissues. Furthermore, PFN2 had been shown promote angiogenesis through exosomes. However, it remains unclear whether contributes the progression metastasis of angiogenesis. We report here that overexpression (OE) increased, whereas its knockdown (KD) decreased proliferation, migration, invasion H446. The exosomes from OE-H446...
Immunosuppression in a tumor microenvironment is associated with enhanced progression. Natural killer group 2 (NKG2) family proteins, including inhibitory receptors and activators, can be used as attractive targets for immunotherapy of immune checkpoint inhibition. We further explore the expression level prognostic value NKG2A NKG2D hepatitis B virus-related hepatocellular carcinoma (HBV-HCC).This study was prospective involving 92 patients HBV-HCC, 16 HBV-related liver cirrhosis, 18 CHB, 38...
Abstract Background RNA methylation is a crucial in many biological functions, and its aberrant regulation associated with cancer progression. N6-Methyladenosine (m6A), 5-Methylcytosine (m5C), N1-methyladenosine (m1A) are common modifications of methylation. However, the effect m6A/m5C/m1A hepatocellular carcinoma (HCC) remains unclear. Method The transcriptome datasets, clinic information, mutational data 48 regulator genes were acquired from TCGA database, prognostic hazard model was...
Background: Primary thoracic lymphangioma is a rare disease. Most of the previous studies are comprised individual case reports, with very limited number patients included. Objective: This study aims to investigate chest computed tomography (CT) imaging features and clinical manifestations lymphangioma, thereby enhancing our understanding condition. Methods: A retrospective analysis was conducted on 62 diagnosed comprising 32 males 30 females. The focused analyzing CT observed in these...
ABSTRACT Objectives The priming mechanism of adaptive immunity in oral mucositis remains unclarified. This study aimed to elucidate the mechanisms lichen planus (OLP), with a specific focus on role inducible tertiary lymphoid structures (iTLSs) and stromal‐immune microenvironments within OLP. Materials Methods We employed single‐cell RNA sequencing multiplex immunofluorescence staining characterize spatial characteristics transcriptional signature iTLSs To investigate whether presence...
Objective: Comprehensive characterization of B-cell phenotypes and spatial distribution in oral lichen planus (OLP) related lichenoid lesions (OLL), with an emphasis on transcriptomic profiling functional analysis, to uncover the epigenetic mechanisms underlying B cell-mediated immune regulation within mucosal microenvironment. Methods: Single-cell RNA sequencing raw data were sourced from GSE211630 database, encompassing samples 2 cases erosive (EOLP), 3 non-erosive (NEOLP) 1 healthy...
Imaging examinations exhibit a certain rate of missed detection for distant metastases gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). This study aims to develop and validate risk prediction model the prognosis GEP-NENs. included patients diagnosed with (GEP-NENs) from Surveillance, Epidemiology, End Results (SEER) database between 2010 2015. External validation was performed China-Japan Union Hospital Jilin University. Univariate multivariate logistic regression analyses were...
Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim study was to explore differences in UGT1A1 gene mutations, which cause both CNS GS, pathological changes between CNS-II GS. Ninety-five Chinese patients with hereditary unconjugated hyperbilirubinemia were enrolled study. Peripheral blood samples obtained from used evaluate levels for testing....