A5100341251- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- RNA modifications and cancer
- Liver Diseases and Immunity
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Endoplasmic Reticulum Stress and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Migraine and Headache Studies
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Heavy metals in environment
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Heavy Metal Exposure and Toxicity
- Cholesterol and Lipid Metabolism
- Trigeminal Neuralgia and Treatments
- Cervical and Thoracic Myelopathy
- Hepatocellular Carcinoma Treatment and Prognosis
Capital Medical University
2014-2024
Huzhou Central Hospital
2024
Huzhou University
2024
Beijing Ditan Hospital
2008-2024
National Marine Environmental Forecasting Center
2024
National Institute for Communicable Disease Control and Prevention
2024
Beijing Fengtai Hospital
2024
China Rehabilitation Research Center
2024
Jinzhou Medical University
2024
National Clinical Research Center for Digestive Diseases
2020-2023
Background and Aims: NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier 1 (MPC1) inflammation, fibrosis, insulin sensitivity in obese or NASH mouse models. However, impact of MPC1 on NAFLD-related liver lipid metabolism its role progression require further investigation. Approach Results: expression was measured tissues from normal controls patients with NAFLD. We characterized phenotypes genes...
Spontaneous mutations introduce uncertainty into coronavirus disease 2019 (COVID-19) control procedures and vaccine development. Here, we perform a spatiotemporal analysis on intra-host single-nucleotide variants (iSNVs) in 402 clinical samples from 170 affected individuals, which reveals an increase genetic diversity over time after symptom onset individuals. Nonsynonymous are overrepresented the pool of iSNVs but underrepresented at polymorphism (SNP) level, suggesting two-step fitness...
BACKGROUND The aim of this study was to investigate the clinical characteristics and risk factors associated with anti-tuberculosis (anti-TB) drug-induced liver injury (DILI). MATERIAL AND METHODS This retrospective enrolled 140 hospitalized patients diagnosed anti-TB DILI during January 2009 December 2015. We assessed baseline performed regular follow-up up 24th week assess possible condition. RESULTS population 58.6% male 41.4% female patients; 20.7% were grades 4-5 79.3% 1-3 DILI. Female...
Abstract Introduction Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites differentiate AD from other dementias. Methods Blood were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential 2 93; 92) establish a diagnostic model use metabolite panel. The applied 3 76; dementias, 205) verify its capacity differentiating Results revealed 7 upregulated and 77...
Test-time prompt tuning enhances zero-shot generalization of vision-language models but tends to ignore the relatedness among test samples during inference. Online test-time provides a simple way leverage information in previous samples, albeit with risk collapse due error accumulation. To enhance tuning, we propose DynaPrompt, short for dynamic exploiting relevant data distribution while reducing Built on an online buffer, DynaPrompt adaptively selects and optimizes prompts each sample...
Background and Aims: Chronic kidney disease (CKD) is a recognized extra-hepatic of nonalcoholic fatty liver (NAFLD). With the redefinition NAFLD as metabolic dysfunction-associated steatotic (MASLD), importance cardiovascular factors in MASLD has been highlighted. However, whether remains independently associated with prevalence CKD yet to be determined. Method: We analyzed data from 6567 non-pregnant adults National Health Nutrition Examination Survey 2017–2020. was identified using...
ObjectivesWe carried out a randomized multicentre study in China to investigate whether the clofazimine would improve efficacy of standardized regimen patients with multidrug-resistant tuberculosis (MDR-TB).MethodsPatients MDR-TB managed 17 TB specialist hospitals between September 2009 and 2011 were randomly assigned treatment groups at enrolment. In intervention group, 100 mg per day was added regimen. The primary outcome proportion successful outcomes.ResultsFrom 156 that screened, 74...
Hepatitis C virus (HCV) genotype and subtype are related to disease progression response antiviral therapy. Current HCV distribution data, especially for genotypes 3 6, limited in China. Our purpose was investigate the current distributions chronic hepatitis patients China.Chronic (n = 1012) were enrolled, demographic information possible transmission risk factors collected. Serum samples subjected reverse-transcription polymerase chain reaction, followed by direct DNA sequencing...
Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder of skeletal malformations and progressive extraskeletal ossification. There still no effective treatment for FOP. All FOP individuals harbor conserved point mutations in ACVR1 gene that are thought to cause constitutive activation activate BMP signal pathway. The constitutively active also found be able endothelial-to-mesenchymal transition (EndMT) endothelial cells, which may the formation lesions. MicroRNAs (miRNAs)...
Abstract Background and Aim With the changes in diet structure lifestyle, incidence of fatty liver disease is increasing C hina, especially cities. The goal present study was to accurately determine prevalence risk factors B eijing residents, hina. Methods By using random multistage stratification cluster sampling, residents aged > 20 years Dongcheng District Tongzhou were recruited, questionnaire survey, physical examination, detection fasting glucose, blood lipids biochemistry,...
Trigeminal neuralgia is a sudden, severe condition characterized by stabbing and recurrent pain.Radiofrequency thermocoagulation (RFT) pulsed radiofrequency (PRF) are common surgical interventions used to treat trigeminal neuralgia.This study aimed investigate the therapeutic effects associated complications of combination RFT PRF in treatment neuralgia.Computed tomography-guided percutaneous Gasserian ganglion was performed on 80 patients with neuralgia.Patients were randomly assigned...
Chronic migraine (CM) is a highly disabling and burdensome disease. Wuzhuyu decoction (WZYD), clinical used formula to treat prevent episodic CM, has been reported relieve the hyperalgesia of CM increase brainstem blood serotonin (5-hydroxytryptamine, 5-HT) in model rats previous studies; yet mechanism unclear.This study aimed observe relief effect WZYD investigate mechanistic association with regulation on central peripheral 5-HT.WZYD different doses (3.372, 1.686 0.843 g/kg∙d) positive...