A5101404011- Per- and polyfluoroalkyl substances research
- Bone health and osteoporosis research
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Dietary Effects on Health
- Heavy Metal Exposure and Toxicity
- Gut microbiota and health
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Circadian rhythm and melatonin
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Bone Metabolism and Diseases
- Microbial Community Ecology and Physiology
- Vitamin C and Antioxidants Research
- Salivary Gland Disorders and Functions
- Wastewater Treatment and Nitrogen Removal
- Seaweed-derived Bioactive Compounds
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Atmospheric chemistry and aerosols
- Geochemistry and Elemental Analysis
- Olfactory and Sensory Function Studies
- Plant Physiology and Cultivation Studies
Fudan University
2025
Soochow University
2020-2024
Air Force Medical University
2024
Sichuan University
2015-2024
State Key Laboratory of Oral Diseases
2024
Huazhong University of Science and Technology
2021-2023
Ministry of Ecology and Environment
2023
Beijing University of Technology
2021
Chinese Academy of Inspection and Quarantine
2010-2017
Wenzhou Medical University
2012-2016
Objective Accumulative evidence suggests that gut microbiota play an important role in bone remodeling and hence health maintenance. This study aimed to explore the association of with risk osteoporosis identify potential disease-related taxa, which may be promising targets prevention treatment future. Methods Absolute quantification 16S ribosomal RNA gene sequencing was used detect absolute relative abundances 44 patients 64 controls. In combination one our previous studies, a total 175...
Perfluorooctanesulfonic acid (PFOS), a ubiquitous contaminant, has been used in various industrial applications. Currently few studies have documented the effects of chronic PFOS exposure on lipid metabolism, especially aquatic organisms. The present study defined to low level metabolism F0 adult zebrafish and F1 offspring. Our findings revealed severe fatty degeneration liver males treated with 0.5 μM significant ultrastructure changes associated substance transport or intestines (abnormal...
The homeostasis of circadian clock linked to bile acid (BA) metabolism and gut microbiota has profound benefits in maintaining the health status host. aim this study was investigate prevention regulation apple polyphenol extract (APE) on BA by means modulation rhythms mice. Eighty male C57BL/6 mice were randomized into four groups: 24-hour ad libitum standard chow group (AC), HFD (AF), restricted 12 h daytime feeding (DF), with APE treatment (DP). Five weeks later, sacrificed at 6 intervals...
Apple polyphenol extract (APE) has been reported to possess protective effects against hepatic steatosis. To explore whether APE-induced alleviation of steatosis is SIRT1-dependent, the present study was carried out using wild-type and SIRT1 heterozygous mutant (Sirt1+/-) C57BL/6 mice. On consideration sex disparity related morbidity, both male female mice were included in study. Six eight week old fed a high-fat diet (HFD) randomly assigned one following groups: (1) (wt+HFD), (2) Sirt1+/-...
Bone mineral density (BMD) alterations in response to multivitamin exposure were rarely studied. Our study assessed the association of coexposure six types vitamins (i.e., B12, B9, C, D, A and E) with BMD measurements adults US.Data collected from participants aged ≥ 20 years (n = 2757) U.S. National Health Nutrition Examination Surveys (NHANES) 2005 2006. Multiple linear regression, restricted cubic splines, principal component analysis (PCA) weighted quantile sum (WQS) regression performed...
This study aimed to explore the effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) on apoptosis cell cycle in a zebrafish (Danio rerio) liver line (ZFL). Treatment groups included control group, PFOA-IC(50), PFOA-IC(80), PFOS-IC50 PFOS-IC(80) groups. IC(50) IC(80) concentrations were identified by cellular modeling MTT assays. mRNA levels p53, Bcl-2, Bax, Caspase-3 NF-κB p65 detected qPCR. Cell flow cytometry protein determined western blotting. Both PFOA PFOS...
To investigate the potential contribution of appetite regulation and modulation gut microbiota to ameliorated effects apple polyphenols extracts (APE) on high carbohydrate diet (HCD)-induced body weight (BW) gain, we conducted this study. One hundred C57BL/6 male mice were randomly divided into seven groups fed with following diets for 12 weeks: chow (CON), HCD (HCD), fructose sucrose (HSCD), HSCD 125 or 500 mg/kg·day APE gavage. Compared CON group, BW in increased significantly. induced a...
Di(2-ethylhexyl) phthalate (DEHP) is considered to be an environmental endocrine disruptor at high levels of general exposure. Studies show that DEHP may cause testicular toxicity on human being. In this study, metabonomics techniques were used identify differential endogenous metabolites, draw the network metabolic pathways, and conduct analysis, determine underlying mechanisms induced by DEHP. The results showed inhibited synthesis accelerated β-oxidation fatty acids impaired tricarboxylic...
Background Few studies have explored the association between water intake and mortality risk, findings were inconsistent. Objective This study aimed to explore intake–mortality association, utilizing data from National Health Nutrition Examination Survey (NHANES) 2015 public-linked files released by Center for Statistics. Methods We used diet- mortality-linked of a total 35,463 adults (17,234 men) aged ≥20 years in NHANESs 1999–2014 perform prospective study. The multivariate-adjusted Cox...
Osteoporosis is a skeletal disease characterized by low bone mass, reduced strength, and increased fracture risk. We aimed to investigate the association between combined dietary antioxidant intake likelihood of osteoporosis in premenopausal postmenopausal women, based on data from National Health Nutrition Examination Survey.Nutrient were obtained using two 24-hour recalls. Composite index (CDAI), which refers amounts β-carotene, vitamin A, C, E, selenium, zinc, copper, iron, was then...
Fucoidan has shown better effects on the improvement of acute ulcerative colitis (UC). However, specific mechanisms by which fucoidan improves UC-related behavioral disorders in aged mice, especially its effect gut–brain axis, remain to be further explored. C57BL/6 male mice 8 months were gavaged with 400 or 100 mg/kg bw day for five consecutive weeks, UC being induced ad libitum dextran sulfate sodium (DSS) solution fifth week. The results showed that ameliorated and accompanying anxiety-...
Objective: This study aimed to explore the relationships between common variants of R-spondin/Wnt signaling genes, gut microbiota composition, and osteoporosis (OP) risk in elderly Chinese Han population. Design: Dual-energy X-ray absorptiometry was used obtain OP-associated measurements at multiple skeleton sites among all 1,168 participants. Genotyping data obtained by using next-generation sequencing discovery stage (n = 400, 228 OP patients) SNPscan technology replication 768, 356...
To investigate the potential role of apple polyphenol extract (APE) in prevention and alleviation circadian rhythm disturbances, eighty male C57BL/6 mice fed a high-fat diet (HFD) were randomized into four groups: 24 h ad libitum feeding (AL), 12 restricted nighttime (NF) or daytime (DF), with APE intragastric administration (DF-APE). Five weeks later, sacrificed at 6 intervals over h. Disrupted fluctuations serum lipid profiles hormones, along desynchronization clock genes metabolic...