A5102008147- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 and healthcare impacts
- COVID-19 epidemiological studies
- Poxvirus research and outbreaks
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Bacillus and Francisella bacterial research
- Cerebrospinal fluid and hydrocephalus
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Neurosurgical Procedures and Complications
- Plant Virus Research Studies
- Sepsis Diagnosis and Treatment
- Renal and related cancers
- Biosensors and Analytical Detection
Beijing Ditan Hospital
2014-2025
Capital Medical University
2015-2025
Capital University
2024-2025
Jilin University
2025
Chongqing Medical University
2022-2024
Second Affiliated Hospital of Chongqing Medical University
2022-2024
Chinese PLA General Hospital
2024
Dalian Medical University
2022-2024
Dalian Naval Academy
2024
Guangxi Medical University
2023-2024
Abstract Background Patients with critical illness due to infection the 2019 coronavirus disease (COVID-19) show rapid progression acute respiratory failure. The study aimed screen most useful predictive factor for caused by COVID-19. Methods prospectively involved 61 patients COVID-19 as a derivation cohort, and 54 validation cohort. was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators built predict probability of illness. Results...
Abstract Background Severe ill patients with 2019 novel coronavirus (2019-nCoV) infection progressed rapidly to acute respiratory failure. We aimed select the most useful prognostic factor for severe illness incidence. Methods The study prospectively included 61 2019-nCoV treated at Beijing Ditan Hospital from January 13, 2020 31, 2020. Prognostic of was selected by LASSO COX regression analyses, predict probability 2019-CoV pneumonia. predictive accuracy evaluated concordance index,...
Abstract The emerging monkeypox virus (MPXV) has raised global health concern, thereby highlighting the need for rapid, sensitive, and easy-to-use diagnostics. Here, we develop a single-step CRISPR-based diagnostic platform, termed SCOPE (Streamlined CRISPR On Pod Evaluation platform), field-deployable ultrasensitive detection of MPXV in resource-limited settings. viral nucleic acids are rapidly released from rash fluid swab, oral saliva, urine samples 2 min via streamlined lysis protocol,...
Summary Aging is associated with immune dysfunction, especially T‐cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between exhaustion and senescence. In this study, we immunoglobulin immunoreceptor tyrosine‐based motif ( ITIM ) domain TIGIT ), a novel co‐inhibitory receptor, was upregulated CD 8 + elderly adults. Aged expressed high...
Background The global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases. Progressive lymphopenia, especially in T cells, was prominent clinical feature COVID-19. Activated HLA-DR + CD38 CD8 cells were enriched over prolonged period from the lymphopenia patients who died Ebola influenza infection infected with SARS-CoV-2. However, population reported to play contradictory roles SARS-CoV-2 infection....
Abstract Background and Aims The safety antibody responses of coronavirus disease 2019 (COVID‐19) vaccination in patients with chronic hepatitis B (CHB) virus infection is still unclear, exploration COVID‐19 CHB significant clinical practice. Methods 362 adult 87 healthy controls at an interval least 21 days after a full‐course (21–105 days) were enrolled. Adverse events (AEs) collected by questionnaire. profiles 1, 2 3 months elucidated determination anti‐spike IgG, anti‐receptor‐binding...
On July 23, 2022, the World Health Organization (WHO) declared monkeypox (mpox) outbreak a "Public Emergency of International Concern." Since outbreaks mpox in many countries around world have primarily resulted fatalities among immunocompromised individuals, such as untreated HIV/AIDS patients. eradication smallpox was by WHO 1980, global vaccination against has been gradually discontinued. China also stopped routine 1981. The protective effect vaccine decreased over time due to aging and...
Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. A total 840 chorionic samples from were collected examined FISH. We analyzed incidence type abnormal cases sex ratio samples. also relationship between rate parental age, recurrent sporadic abortion, difference previous artificial those no induced abortion. 832 finally...
Spontaneous mutations introduce uncertainty into coronavirus disease 2019 (COVID-19) control procedures and vaccine development. Here, we perform a spatiotemporal analysis on intra-host single-nucleotide variants (iSNVs) in 402 clinical samples from 170 affected individuals, which reveals an increase genetic diversity over time after symptom onset individuals. Nonsynonymous are overrepresented the pool of iSNVs but underrepresented at polymorphism (SNP) level, suggesting two-step fitness...
Abstract Background The possibility of psychopathological symptoms and related risk factors among normal persons patients infected during the outbreak COVID-19 has been widely investigated. mental health outcomes second wave pandemic remain unclear, especially those with an infection. Thus, this study aims to explore prevalence associated wave. Method A cross-sectional survey was conducted in five isolated wards a designated hospital Beijing, China, from July 1 15, 2020. Mini International...
The global outbreak of monkeypox virus (MPXV) has highlighted the need for rapid molecular diagnostics techniques. In this study, a single-step recombinase polymerase amplification (RPA)-CRISPR/Cas12a system was developed and sensitive detection MPXV. limit assay 1 copy per μL extracted nucleic acids. A heating lysis method integrated to further simplify sample processing workflow shorten time 40 min from result. reaction mixture can be lyophilized improve its accessibility in...
Abstract With the ongoing mutation of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) leading to various variants, there is an urgent need for new diagnostic methods SARS‐CoV‐2 infection. The existing nucleic acid test and antigen suffer from long assay time low sensitivity, respectively. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS)‐based nasal swabs analysis have been demonstrated as a promising technique in infection screening....
Abstract Background With concerns about the disastrous health and economic consequences caused by influenza pandemic, comprehensively understanding global host response to virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, precise miRNAs pathogenesis humans, especially critically ill patients still unclear. Methods We identified cellular involved performing comprehensive miRNA profiling peripheral blood mononuclear...
After a short recovery period, COVID-19 reinfections could occur in convalescent patients, even those with measurable levels of neutralizing antibodies. Effective vaccinations and protective public health measures are recommended for the patients.
Monoclonal antibodies (mAbs) and the post-exposure prophylaxis (PEP) with mAbs represent a very important public health strategy against coronavirus disease 2019 (COVID-19). This study has assessed new Anti-SARS-COV-2 mAb (SA58) Nasal Spray for PEP COVID-19 in healthy adults aged 18 years older within three days of exposure to SARS-CoV-2 infected individual. Recruited participants were randomized ratio 3:1 receive SA58 or placebo. Primary endpoints laboratory-confirmed symptomatic period. A...
Zika virus (ZIKV) has caused major concern globally due to its rapid dissemination and close association with microcephaly in children Gullian-Barr syndrome adults. In this study, we identified a patient returned from Cambodia who experienced high fever, chill myalgia. Lab tests discovered sign of severe liver injury including significantly elevated serum transaminases' level, decreased albumin markedly increased levels lactic dehydrogenase, alpha-hydroxybutyric dehydrogenase creatine kinase...
Abstract The mpox outbreak has subdued with fewer reported cases at the present in high‐income countries. It is known that virus (MPXV) infection been epidemic for more than 50 years African ancestral MPXV strain changed into multiple clades, indicating ongoing evolution of MPXV, which reflects historical neglect Africa, especially after smallpox eradication, and bestows danger severe epidemics future. thus imperative to continue development diagnostics treatments so we can be prepared event...
The recent monkeypox epidemic outbreaks worldwide highlight the urgent need for fast and precise diagnostic solutions, especially in resource-limited settings. Here, a two-dimensional nanozyme-catalyzed colorimetric CRISPR assay microfluidic detection of virus (MPXV) was established. We utilized graphene oxide as substrate adsorption gold seeds deposition porous Pt shell to prepare high-performance GO@Pt nanomaterials. viral nucleic acids released from clinical samples initiated single-step...
Permian magmatic rocks are extensively distributed in the East Kunlun Orogenic Belt (EKOB), yet controversies persist regarding petrogenesis of granitoid and tectonic evolution Buqingshan-A’nyemaqing Ocean (BAO), a Paleo-Tethys oceanic branch. This study addresses these debates through petrological analyses, whole-rock geochemistry, zircon U-Pb-Lu-Hf isotopic investigations newly identified granitoids EKOB. The monzogranite (MG) quartz porphyry (QP) yield weighted mean ages 254.7...