A5022272694- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Neuroendocrine Tumor Research Advances
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- CAR-T cell therapy research
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Mechanisms of cancer metastasis
The University of Texas MD Anderson Cancer Center
2019-2025
Institute of Hematology & Blood Diseases Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Guangzhou Medical University
2025
Xinjiang Institute of Materia Medica
2025
Xinjiang University
2025
Second Affiliated Hospital of Zhejiang University
2024
Dalian Medical University
2022-2024
Southern Medical University
2020-2024
Harbin Medical University
2007-2024
Hepatocellular cell death and macrophage proinflammatory activation contribute to the pathology of various liver diseases, during which XBP1 plays an important role. However, function mechanism in thioacetamide (TAA)-induced acute injury (ALI) remains unknown. Here, we investigated effects inhibition on promoting hepatocellular pyroptosis activate STING signaling ALI. While both TAA- LPS-induced ALI triggered hepatocytes, hepatocyte-specific knockout mice exhibited exacerbated with increased...
Molecular modifiers of KRASG12C inhibitor (KRASG12Ci) efficacy in advanced KRASG12C-mutant NSCLC are poorly defined. In a large unbiased clinicogenomic analysis 424 patients with non-small cell lung cancer (NSCLC), we identified and validated coalterations KEAP1, SMARCA4, CDKN2A as major independent determinants inferior clinical outcomes KRASG12Ci monotherapy. Collectively, comutations these three tumor suppressor genes segregated into distinct prognostic subgroups captured ∼50% those early...
Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if how hepatocyte regulates macrophage stimulator of interferon genes (STING) activation the development spontaneous damage, fibrosis, tumorigenesis.We used a transforming growth factor-beta-activated kinase 1 (TAK1) deficiency-induced model tumorigenesis to investigate its impact on STING signalling. Primary hepatocytes macrophages were for vitro...
Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability. Given known epigenetic regulation critical SCLC programs, we hypothesized that subtype-specific patterns DNA methylation could be detected tumor or blood from patients. Using genomic-wide reduced-representation bisulfite sequencing (RRBS) two cohorts totaling 179 patients...
Abstract Inactivating TP53 mutations leads to a loss of function p53, but can also often result in oncogenic gain-of-function (GOF) mutant p53 (mutp53) proteins which promotes tumor development and progression. The GOF activities are well documented, the mechanisms involved remain poorly understood. Here, we study mutp53 interactome find that by targeting minichromosome maintenance complex components (MCMs), predisposes cells replication stress chromosomal instability (CIN), leading...
IntroductionThe combination of programmed cell death protein-1 or death-ligand 1 immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced NSCLC, but mechanisms underlying this synergy remain incompletely understood. In study, we explored relationships between neoadjuvant microenvironment (IME) resectable NSCLC to identify novel by which may enhance effect blockade.MethodsGenomic, transcriptomic, profiling data 511 patients treated with followed surgery (NCT)...
The combination of ISA101, a human papilloma virus (HPV) 16 peptide vaccine, and nivolumab showed promising response rate 33% in patients with incurable HPV-16
Background: Prostate cancer is usually considered as immune "cold" tumor with poor immunogenic response and low density of tumor-infiltrating cells, highlighting the need to explore clinically actionable strategies sensitize prostate immunotherapy.In this study, we investigated whether docetaxel-based chemohormonal therapy induces immunologic changes potentiates checkpoint blockade immunotherapy in cancer.Methods: We performed transcriptome histopathology analysis characterize...
Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAPdef) in tumors with 9p21 loss and hypothetically renders susceptible to synthetic lethality by antifolates targeting de novo purine synthesis. Here we report our single arm phase II trial (NCT02693717) that assesses pemetrexed MTAPdef urothelial carcinoma (UC) primary endpoint of overall response rate (ORR). Three 7 enrolled patients show (ORR 43%). Furthermore, a historic cohort...
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions mitochondrial to tumor growth therapy resistance evident, but drugs targeting have repeatedly failed in the clinic. Our study pancreatic ductal adenocarcinoma (PDAC) finds that cellular lipid composition influence cancer cell sensitivity pharmacological inhibition electron transport chain complex I. Profiling...
Abstract Background With concerns about the disastrous health and economic consequences caused by influenza pandemic, comprehensively understanding global host response to virus infection is urgent. The role of microRNA (miRNA) has recently been highlighted in pathogen-host interactions. However, precise miRNAs pathogenesis humans, especially critically ill patients still unclear. Methods We identified cellular involved performing comprehensive miRNA profiling peripheral blood mononuclear...
Abstract AXL, a TAM (TYRO3, and MERTK) family receptor tyrosine kinase, is increasingly being recognized as key determinant of resistance to targeted therapies, well chemotherapy radiation in non–small cell lung cancer (NSCLC) other cancers. We further show here that high levels AXL epithelial-to-mesenchymal transition were frequently expressed subsets both treatment-naïve treatment-relapsed NSCLC. Previously, we others have demonstrated role for mediating DNA damage response (DDR),...
Abstract Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response immunotherapy. Here, using multi-region whole exome/T cell receptor (TCR) sequencing as well immunohistochemistry, we reveal a rather homogeneous mutational landscape but extremely cold heterogeneous TCR repertoire in limited-stage SCLC tumors (LS-SCLCs). Compared localized non-small cancers, LS-SCLCs have similar predicted...
The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and known to modulate the balance between two major pathways metabolism: glycolysis mitochondrial respiration. This duality underscores importance further investigation into its role SCLC metabolism could lead insights metabolic targeting approaches.We investigated differences transcriptional metabolomics datasets based on cMYC expression patient line samples. Metabolic pathway utilization was...
Fibrosis is the final common pathway leading to end stage chronic kidney disease (CKD). However, function of protein palmitoylation in renal fibrosis and underlying mechanisms remain unclear. In this study, we observed that expression palmitoyltransferase ZDHHC18 was significantly elevated unilateral ureteral obstruction (UUO) folic acid (FA)-induced mouse models, upregulated fibrotic kidneys patients. Functionally, tubule-specific deletion attenuated tubular epithelial cells partial...
Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged (O2), ROS, photodynamic-induced coordination-driven self-assembly transition-metal Ru, photosensitizer indocyanine green (ICG), organic ligand dithiobispropionic acid (DTPA). Then, IRD camouflaged...
Abstract Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates up to 50%. Immune system dysregulation implicated in LGLL. Promising results for thalidomide, an immunomodulatory drug, combined with prednisone and methotrexate (TPM), were observed our pilot study. This multicenter study evaluated efficacy safety a...
Sotorasib (AMG510) and adagrasib (MRTX849) have shown significant efficacy in KRASG12C mutant NSCLC, but acquired resistance occurs within 6-12 months. While some arises from new mutations, over half of the resistant cases lack identifiable genomic alterations. We hypothesize that is driven by signaling network rewiring, creating therapeutic vulnerabilities. To investigate (AR) mechanisms, multiple AR models, including cell lines (H23AR & H358AR), PDXs (TC303AR TC314AR), CDXs (H358AR...
Interferon-inducible transmembrane proteins (IFITMs) restrict infection by several viruses, such as influenza A virus, West Nile virus and dengue virus. It has not been determined whether porcine IFITMs (pIFITMs) inhibit pseudorabies (PRV), an enveloped, double-stranded DNA which is the etiological agent of Aujeszky's disease in pigs. Here, we report that PRV elicited pIFITM1 expression PK15 kidney epithelial cells 3D4/21 alveolar macrophages. pIFITM2 pIFITM3 was only elevated during...