A5100631384- Hippo pathway signaling and YAP/TAZ
- melanin and skin pigmentation
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Skin Protection and Aging
- Tuberculosis Research and Epidemiology
- Breast Cancer Treatment Studies
- Mycobacterium research and diagnosis
- Chemical Reactions and Isotopes
- Immune cells in cancer
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Photodynamic Therapy Research Studies
- Biochemical Analysis and Sensing Techniques
- Medical Imaging Techniques and Applications
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
Jinan University
2025
Shanxi Medical University
2025
Second Hospital of Shanxi Medical University
2025
Wuhan University
2015-2024
Renmin Hospital of Wuhan University
2015-2024
University of Oxford
2024
Peking University
2024
Peking University People's Hospital
2024
Huashan Hospital
2024
Fudan University
2024
The Tuberous Sclerosis Complex component, TSC1, functions as a tumor suppressor via its regulation of diverse cellular processes, particularly cell growth. TSC1 exists in complex with TSC2 and primarily key negative regulator mammalian target rapamycin 1 (mTORC1) signaling protein synthesis, although the TSC1/TSC2 also shows mTORC1-independent outputs to other pathways. Here, we explored role various aspects stem biology dissected extent which are executed mTORC1-dependent versus Using...
Abstract Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology pathogenesis of MDA5 DM are still largely unknown. Here we describe the immune signatures via single-cell RNA sequencing, flow cytometry multiplex immunohistochemistry in peripheral B T cells affected tissue samples from one patient. We find strong antibody-secreting cell CD8...
Autophagy is a degradative pathway that delivers cellular components to the lysosome for degradation. The role of autophagy in cell differentiation poorly understood. Here we show CaMKII can directly phosphorylate Beclin 1 at Ser90 promote K63-linked ubiquitination and activation autophagy. Meanwhile, also inhibitor 1/2 (Id-1/2) by catalyzing phosphorylation Id proteins recruiting TRAF-6. Ubiquitinated Id-1/Id-2 then bind p62 be transported autolysosomes degradation promotes neuroblastoma...
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions mitochondrial to tumor growth therapy resistance evident, but drugs targeting have repeatedly failed in the clinic. Our study pancreatic ductal adenocarcinoma (PDAC) finds that cellular lipid composition influence cancer cell sensitivity pharmacological inhibition electron transport chain complex I. Profiling...
Eosinophils are key effector cells mediating airway inflammation and exacerbation in patients with severe eosinophilic asthma. They present increased numbers activation states the mucosa lumen. Interleukin-5 (IL-5) is eosinophil growth factor that thought to play a role priming activation. However, mechanism of these effects still not fully understood. The anti-IL-5 antibody mepolizumab reduces counts modestly but has large beneficial effect on frequency exacerbations asthma, suggesting...
An integrated genomic and functional analysis to elucidate DNA damage signaling factors promoting self-renewal of glioma stem cells (GSCs) identified proliferating cell nuclear antigen (PCNA)-associated factor (PAF) up-regulation in glioblastoma. PAF is preferentially overexpressed GSCs. Its depletion impairs maintenance without differentiation reduces tumor-initiating frequency. Combined transcriptomic metabolomic analyses revealed that supports GSC maintenance, part, by influencing...
Pre-eclampsia (PE) is a leading cause of maternal and perinatal morbidity mortality but the exact underlying mechanisms PE pathogenesis remain elusive. Accumulated data suggested that long noncoding RNAs (lncRNAs) play important roles in PE. The present study identified changes lncRNA Linc00261 its effects on trophoblasts invasion migration. Our results showed expression was upregulated placental tissues women compared with those healthy pregnant women. Overexpression suppressed cell...
Background Topotecan produces DNA damage that induces autophagy in cancer cells. In this study, sensitising topotecan to colon cells with different P53 status via modulation of was examined. Methodology/Principal Findings The induced by treatment resulted cytoprotective wild-type p53. However, mutant p53 or knockout, autophagy-associated cell death. cells, activated p53, upregulated the expression sestrin 2, phosphorylation AMPKα subunit at Thr172, and inhibited mTORC1 pathway. Furthermore,...
Preeclampsia (PE) is a pregnancy-related syndrome characterized by hypertension and proteinuria after the 20th week of gestation. The long noncoding RNAs (lncRNAs) have been recently discovered for their roles in pathogenesis PE. This study aimed at determining expression lncRNA MIR503 host gene (MIR503HG) PE placental tissues exploring molecular mechanism underlying MIR503HG-mediated trophoblast cell proliferation, invasion, migration. level MIR503HG tissues, HTR-8/SVneo, JEG3 cells was...
Clinical studies have proven that ultraviolet B (UVB) based phototherapy can induce perifollicular and marginal repigmentation patterns in the skin of vitiligo patients. It is, however, difficult to conceive how melanocytes easily exit from their tightly interconnected epidermal microenvironment re‑enter a different location establish new network with neighboring keratinocytes. While it is known matrix metalloprotease 9 (MMP9) involved degradation extracellular physiological or pathological...
A singularly perturbed convection-diffusion problem posed on the unit square in <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="double-struck upper R squared"> <mml:semantics> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="double-struck">R</mml:mi> </mml:mrow> <mml:mn>2</mml:mn> </mml:msup> <mml:annotation encoding="application/x-tex">\mathbb {R}^2</mml:annotation> </mml:semantics> </mml:math>...
Abstract Background Our previous studies demonstrated that 1-Pyrroline-5-carboxylate (P5C) released by prostate cancer cells inhibits T cell proliferation and function increasing SHP1 expression. We designed this study to further explore the influence of P5C on metabolism, produced an antibody for targeting restore functions cells. Method co-immunoprecipated from analyzed proteins were bound it using liquid chromatography mass spectrometry (LC/MS-MS). The metabolism was also detected...
Abstract KDM6B is an epigenetic regulator that mediates transcriptional activation during differentiation, including in bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). Overexpression of has been reported BM HSPCs patients with myelodysplastic syndromes (MDS) chronic myelomonocytic leukemia (CMML). Whether the overexpression contributes to pathogenesis these diseases remains be elucidated. To study this, we generated a Vav-KDM6B mouse model, which overexpresses compartment....
Although vitamin C (VC, L-ascorbic acid) has been widely used as a skin lightening agent for long time, the mechanism by which it inhibits melanogenesis remains poorly understood. It is well-documented that intramelanocytic pH an important factor in regulating tyrosinase function and melanosome maturation. The activity of tyrosinase, rate-limiting enzyme required melanin synthesis, generally minimal acidic environment. Given VC compound, we might speculate intracellular acidification...