A5008775335- Isotope Analysis in Ecology
- Air Quality and Health Impacts
- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Conflict of Laws and Jurisdiction
- Geology and Paleoclimatology Research
- Energy and Environment Impacts
- Facial Rejuvenation and Surgery Techniques
- Reservoir Engineering and Simulation Methods
- Legal principles and applications
- Environmental Toxicology and Ecotoxicology
- Drilling and Well Engineering
- Remote Sensing and Land Use
- Methane Hydrates and Related Phenomena
- Reconstructive Surgery and Microvascular Techniques
- Marriage and Family Dynamics
- Orthodontics and Dentofacial Orthopedics
- Hydraulic Fracturing and Reservoir Analysis
- Cancer-related molecular mechanisms research
- Advanced Computational Techniques and Applications
- Toxic Organic Pollutants Impact
- Reconstructive Facial Surgery Techniques
- RNA modifications and cancer
- Hydrocarbon exploration and reservoir analysis
- Power Systems and Technologies
Plastic Surgery Hospital
2008-2025
Nanjing Medical University
2013-2025
Beijing University of Chinese Medicine
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2010-2024
Guangdong Provincial People's Hospital
2024
China National Environmental Monitoring Center
2012-2023
JTEC Corporation (Japan)
2023
Inventec (China)
2023
Aviation General Hospital
2021-2023
Bacteria influence site‐specific disease etiology and the host's ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs). Lung cancer in Xuanwei, China has been attributed PAH‐rich household air pollution from burning coal. This study seeks explore role of lung microbiota among never smoking Xuanwei women how coal may these associations. DNA sputum buccal samples cases ( n = 8, duplicate) controls two villages was extracted using a multi‐step enzymatic physical...
Oxidative stress-mediated ferroptosis and macrophage-related inflammation play an important role in various liver diseases. Here, we explored if how hepatocyte regulates macrophage stimulator of interferon genes (STING) activation the development spontaneous damage, fibrosis, tumorigenesis.We used a transforming growth factor-beta-activated kinase 1 (TAK1) deficiency-induced model tumorigenesis to investigate its impact on STING signalling. Primary hepatocytes macrophages were for vitro...
High-resolution stable-isotope and accelerator mass spectrometry 14 C measurements in 25 box piston cores from the Labrador Sea allow reconstruction of major paleoceanographical changes during last ~ 200 ka this basin also document links between interior Laurentide Ice Sheet North Atlantic Ocean interval. Two deep circulation regimes are indicated by contrasting sedimentation rates on slopes: (i) modern situation is characterized a gyre Deep Water (NADW) components into basin, which...
The combustion of biomass and coal is the dominant source household air pollution (HAP) in China, contributes significantly to total burden disease Chinese population. To characterize HAP exposure related solid fuel use ventilation patterns, an assessment study 163 nonsmoking female heads households enrolled from 30 villages was conducted Xuanwei Fuyuan, two neighboring rural counties with high incidence lung cancer due burning smoky (a bituminous coal, which health evaluations usually...
Keloids are complex pathological skin scars characterised by excessive growth of fibrous tissue and abnormal accumulation extracellular matrix (ECM). Despite various treatment options available, the keloids remains a major clinical challenge due to high recurrence rates inconsistent therapeutic outcomes. By collecting three keloid tissues normal samples utilising single-cell RNA sequencing (scRNA-seq), we delved into cellular heterogeneity molecular mechanisms keloids. Our study identified...
We examined respiratory health effects of long-term exposure to ambient air pollution in 7,621 schoolchildren residing eight districts four Chinese cities. The cities exhibited wide between-city and within-city gradients levels size fractions particulate matter [less than or equal 2.5 micro m aerodynamic diameter (PM(2.5)), between 10 (PM(10-2.5)), less (PM(10)), total suspended particulates (TSP)] two gaseous pollutants (SO(2) NO(x)). Informed consent written responses questionnaires about...
Three size fractions of particulate matter (PM), i.e., fine particles (PM2.5), coarse (PM2.5-10), and PM10, were measured at the school yards eight elementary schools in four large Chinese cities during 1995 1996. These schools, one located an urban district a suburban each city, served as principal bases for air pollution epidemiologic study. All PM samples collected on Teflon filters using dichotomous samplers analyzed gravimetrically mass concentrations. A subset elements standard XRF...
Piston cores from the Ontong‐Java Plateau collected during Eurydice expedition have been used to estimate regional geomagnetic paleointensity. Rock magnetic measurements of sediments show that (1) remanence is carried by stable pseudo‐single domain magnetite, (2) grain sizes and concentrations are relatively uniform with respect normalization technique (3) susceptibility an adequate parameter for normalizing remanent intensity in order determine relative variations paleomagnetic field. We...
The Sonic hedgehog (SHH) protein produced in the zone of polarising activity (ZPA) is a major determinant identity and numbers digits early limb development. Preaxial polydactyly types II (PPD2) III (PPD3) have been mapped to critical region at 7q36, subsequently shown be caused by point mutations ZPA regulatory sequence (ZRS), long range cis-regulator for SHH gene. Triphalangeal thumb-polysyndactyly syndrome (TPTPS) syndactyly type IV (SD4) were also 7q36 but pathogenic ZRS not yet...
Exposure to polycyclic aromatic hydrocarbons (PAHs) from burning "smoky" (bituminous) coal has been implicated as a cause of the high lung cancer incidence in counties Xuanwei and Fuyuan, China. Little is known about variations PAH exposure throughout region nor how fuel source stove design affects exposure. Indoor personal resulting solid combustion Fuyuan was investigated using repeated 24 h particle bound gas-phase measurements, which were collected 163 female residents Fuyuan. 549 (283...
Differential dissolution affects the isotopic composition of different species planktonic foraminifera in ways. In two studied here cores from Ontong Java Plateau, less resistant species, Globigerinoides sacculifer , is more readily affected at a shallower depth than Pulleniatina obliquiloculata (2.9 versus 3.4 km), but shows smaller and predictable response to partial (0.2 0.3 per mil 0.6 0.7 mil). Comparison values last glacial period with those late Holocene indicates that apparent effect...
Xuanwei and Fuyuan, located in the Yunnan province southwest of China, are known to have a high incidence lung cancer caused by indoor airborne polycyclic aromatic hydrocarbons (PAHs) generated during bituminous coal combustion for heating cooking unvented households. In this study, outdoor air was sampled at 38 sampling sites around these areas January 2007. The concentrations 16 PAHs were analyzed. sources two counties also investigated. Quartz filters polyurethane foam used collect...
The Chinese national pollution census has indicated that the domestic burning of solid fuels is an important contributor to nitrogen dioxide (NO2) and sulfur (SO2) emissions in China. To characterize indoor NO2 SO2 air concentrations relation fuel use stove ventilation rural counties Xuanwei Fuyuan, Yunnan Province, China, which have among highest lung cancer rates nation, a total 163 participants 30 selected villages were enrolled. Indoor 24-h samples collected each household over two...
Households in Xuanwei and Fuyuan, China, possess hazardous levels of fine particulate matter with an aerodynamic diameter <2.5 microns (PM2.5) polycyclic aromatic hydrocarbons (PAHs) from coal combustion. Previous studies found that increased exposure to PM2.5 benzo[a]pyrene (BaP; a PAH) were associated decreased mitochondrial DNA copy number (mtDNAcn), marker oxidative stress. We further evaluated these associations cross-sectional study 148 healthy non-smoking women Fuyuan. Personal BaP...
It has been reported that 1,25 dihydroxyvitamin D [1,25(OH)2D] deficiency leads to the loss of mandibular bone, however mechanism is unclear. We investigated whether Sirt1/FOXO3a signaling pathway involved in this process. Using a 1,25(OH)2D model induced by genetic deletion mice 25-hydroxyvitamin D-1α hydroxylase [1α(OH)ase-/- mice]. first documented sharp reduction expression levels Sirt1 1α(OH)ase-/- vivo. Next, we demonstrated dose-dependent upregulation treatment with exogenous...