A5111148686- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Horticultural and Viticultural Research
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Pressure Ulcer Prevention and Management
- Skin Protection and Aging
- Nerve injury and regeneration
- Cancer and Skin Lesions
- Ear and Head Tumors
- Adipokines, Inflammation, and Metabolic Diseases
- Nonmelanoma Skin Cancer Studies
- melanin and skin pigmentation
Plastic Surgery Hospital
2025
Nanjing Medical University
2025
Shanghai Ninth People's Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Keloids are complex pathological skin scars characterised by excessive growth of fibrous tissue and abnormal accumulation extracellular matrix (ECM). Despite various treatment options available, the keloids remains a major clinical challenge due to high recurrence rates inconsistent therapeutic outcomes. By collecting three keloid tissues normal samples utilising single-cell RNA sequencing (scRNA-seq), we delved into cellular heterogeneity molecular mechanisms keloids. Our study identified...
Abstract Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m 1 A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect skin fibrosis by reshaping N6‐methyladenosine (m 6 A) RNA modification pattern. First, exhibited specific upregulation within hypertrophic scars (HTS), accompanied N1‐methyladenosine hypomethylation. Moreover, multiomics analyses identified METTL3, critical writer enzyme...
Diabetes is an extremely costly disease, one-third of which are attributed to the management diabetic foot disease including chronic, non-healing, ulcers (DFUs). Therefore, much effort needed understand pathogenesis DFUs and novel therapeutics. We utilized exosome staining confirm interaction between fibroblast-derived exosomes macrophages. Subsequently, we employed public data qPCR screen for upregulated miRNAs in DFUs. The relationship was validate miR-93-5 ATG16L1 through prediction...
Delayed diabetic wound (DBW) healing is a severe complication of diabetes, characterized notably by peripheral sensory neuropathy. The underlying mechanism nerves and DBW remain unclear. Here, we demonstrate the role calcitonin gene-related peptide (CGRP) in regulating epithelialization angiogenesis DBW. Subsequently, design synthesis gelatin methacryloyl (GelMA-CGRP) hydrogel that slowly releases CGRP, evaluated its effect on promoting healing. results show CGRP abnormally downregulated...
Keloids are characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix (ECM) a major global health care burden among cutaneous diseases. However, the function long noncoding RNA (lncRNA)-mediated ECM remodeling during pathogenesis keloids is still unclear. Herein, we identified transcript, namely, lymphocyte-specific protein 1 pseudogene 5 (LSP1P5), that modulates component deposition in keloids. First, high-throughput transcriptome analysis showed...
In this report, we present the case of a 55-year-old woman with 30-year history multiple familial trichoepithelioma (MFT), facial surface tumors that progressively worsened, causing ventilation disorders. order to improve patient's appearance and functional impairment, performed two-step surgical excision skin grafting procedure post diagnosis through genetic testing. The 18-month follow-up confirmed effect was satisfactory without obvious recurrence. Based on outcome, have developed...