A5101621081- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organ and Tissue Transplantation Research
- Connective Tissue Growth Factor Research
- Facial Rejuvenation and Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Laser Applications in Dentistry and Medicine
- RNA modifications and cancer
- Traditional Chinese Medicine Studies
- Diagnosis and Treatment of Venous Diseases
- Trauma Management and Diagnosis
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Cellular Mechanics and Interactions
- Cleft Lip and Palate Research
- Cancer-related molecular mechanisms research
- Body Contouring and Surgery
- Nerve Injury and Rehabilitation
- Healthcare and Venom Research
- Bone fractures and treatments
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Ganzhou People's Hospital
2025
Guangdong Provincial People's Hospital
2025
Chinese Academy of Geological Sciences
2024
National Natural Science Foundation of China
2015-2021
Shandong University of Technology
2020
Shanghai Municipal Education Commission
2018
SAIC-GM (China)
2015-2017
Ludwig-Maximilians-Universität München
2014
Abstract Epigenetic modifications serve as crucial molecular switches for pathological fibrosis; howbeit the role of m 1 A in this condition remains enigmatic. Herein, it is found that ALKBH3 exerts a pro‐fibrotic effect skin fibrosis by reshaping N6‐methyladenosine (m 6 A) RNA modification pattern. First, exhibited specific upregulation within hypertrophic scars (HTS), accompanied N1‐methyladenosine hypomethylation. Moreover, multiomics analyses identified METTL3, critical writer enzyme...
Botulinum toxin type A has been increasingly used to improve the lower face contour in masseter hypertrophy. Different dosages and injection techniques are suggested literature, but ideal approach remains unclear. This study aimed establish an objective classification method for a personalized botulinum protocol.A combination of clinical palpation, B-mode ultrasound examination, anatomical dissection studies was applied classify regarding bulging on clenching muscle thickness normal...
Abstract Osteosarcoma, the most prevalent malignant bone tumor among adolescents, frequently exhibits limited responsiveness to immunotherapy, a challenge attributed poorly understood underlying mechanisms. Here, we identify enhanced polyamine biosynthesis as key driver of osteosarcoma progression and immunotherapy resistance. We show that cell proliferation growth rely on availability disruption synthesis significantly boosts cytotoxic efficacy TCR-engineered T cells against cells....
Total face skin and soft-tissue defects remain one of the biggest challenges in reconstructive surgery. Reconstruction entire with uniform coverage delicate features is difficult to achieve. To avoid patchwork result seen multiple flaps grafts, 1 monoblock flap that has similar color, texture, thickness might be an ideal option minimize incisional scars several surgical procedures but unavailable current approaches because lack sufficient matched tissue unreliable blood supply for such a...
Background: Keloid scarring impairs patients’ quality of life, and although many therapeutic strategies have been developed, most remain unsatisfactory because limited understanding the mechanisms underlying keloid development. Methods: A microarray gene expression data set from tissue was acquired Gene Expression Omnibus. Differentially expressed genes in fibroblasts keratinocytes underwent functional annotation pathway analysis. Weighted coexpression network analysis applied to identify...
The thoracic branch of supraclavicular artery (TBSA) flap has been widely used to reconstruct face and neck defects. However, the branches (SCA) exhibit considerable anatomical variations. aim this study was evaluate compare role contrast-enhanced ultrasound (CEUS) with 3-dimensional (3D) reconstruction regular color duplex ultrasonography (CDUS) in preoperative assessment TBSA flap.From May 2009 October 2013, 20 patients (involving 26 flaps) receiving anterior chest flaps for lower...
Hypertrophic scar (HTS) is a common pathologic dermal fibroproliferative disease after skin injury. Transforming growth factor β (TGF-β) plays central role in HTS formation and development. Thrombospondin-1 (TSP-1) activates latent TGF-β by binding to latency-associated peptide-β on structure. So far, LSKL peptide was shown selectively antagonize TSP-1. In this study, TSP-1 first confirmed be highly expressed HTS. proven inhibit the overexpression of extracellular matrix contractile ability...
Rationale: Mechanical stimuli in the microenvironment are considered key regulators of cell function.Clinically, mechanical force (tissue expander) is widely used to regenerate skin for post-burn or trauma repair, implying that stretching can promote regeneration and proliferation.However, underlying mechanism remains unknown.Methods: Microarray analysis was utilized detect hub gene.The expression Cdh1 as examined cells tissues by western blot, q-PCR immunohistochemistry staining...
Hypertrophic Scars (HTSs) are a complex fibroproliferative disorder, and their exact mechanism is still not fully understood. In this study, we first found that cystic fibrosis transmembrane conductance regulator (CFTR) expression was downregulated in human hypertrophic scars at the RNA protein levels by microarray data analysis, RT-PCR, immunofluorescence (IF) staining. To validate downregulation of CFTR involved formation HTSs, then applied mechanical overloading intervention both wild...
Prefabricated flap is an important technique to reconstruct massive face and neck skin defects. But its vascularization remains unpredictable often leads abnormal blood supply of the harvested flap, even necrosis. Flap supercharging turbo techniques are effectively used improve supply. However, few studies have been reported on application these in prefabricated induced expanded flaps.From March 2008 September 2012, 13 patients who soft tissue defects were treated with cervicothoracic flap....
Various techniques have been developed for postburn neck reconstruction, but a treatment algorithm is needed. We retrospectively reviewed all patients treated contracture at our institution between February 2008 and December 2015. Necks were divided into one anterior subunit two lateral subunits marked by the sternocleidomastoid muscle. Deformities categorized three types according to their size location. Type I deformities involve less than subunit, type II least subunits, III affect or...
The face is one of the most important regions human body and contains complicated delicate features that define identity a person. Treatment for extensive facial deformities requires resurfacing skin defects restoring missing features. To date, it remains major challenge to reconstructive surgeons.The authors reviewed their patients Type III IV introduce an integrated method total reconstruction. entire management included flap prefabrication, over-expansion, bone marrow mononuclear cell...
Tissue expansion is a commonly performed therapy to grow extra skin invivo for reconstruction. While mechanical stretch-induced epidermal changes have been extensively studied in rodents and cell culture, little known about the mechanobiology of human epidermis vivo. Here, we employed single-cell RNA sequencing interrogate during long-term tissue clinical settings. We also verified main findings at protein level by immunofluorescence analysis independent samples. Our data show that expanding...
Head and neck squamous carcinoma (HNSC) is the most prevalent malignancy of head regions. Long noncoding RNAs (lncRNAs) are vital in tumorigenesis regulation. However, role lncRNAs HNSC requires further exploration. Herein, through bioinformatic assays using The Cancer Genome Atlas (TCGA) datasets, rapid amplification cDNA ends (RACE) assays, RNA-FISH, we revealed that a novel cytoplasmic transcript, HNSC-associated transcript 1 (HNSCAT1, previously recognized as linc01269), was...