A5101992186- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nanoplatforms for cancer theranostics
- Bone health and osteoporosis research
- Uterine Myomas and Treatments
- RNA modifications and cancer
- Tea Polyphenols and Effects
- Epigenetics and DNA Methylation
- Aquaculture Nutrition and Growth
- Cholesterol and Lipid Metabolism
- Gynecological conditions and treatments
- SARS-CoV-2 and COVID-19 Research
- Aquaculture disease management and microbiota
- Cancer, Stress, Anesthesia, and Immune Response
- Liver physiology and pathology
- Acupuncture Treatment Research Studies
- Endoplasmic Reticulum Stress and Disease
- Sexual function and dysfunction studies
- Free Radicals and Antioxidants
- Mast cells and histamine
- Immune cells in cancer
- Myofascial pain diagnosis and treatment
- Pancreatic function and diabetes
Hubei University
2025
The University of Texas MD Anderson Cancer Center
2022-2025
Southern Medical University
2023
Harbin Medical University
2015-2023
Tianjin University
2023
Nantong University
2023
Hubei University of Technology
2023
Dalarna University
2023
Guangxi University
2021
Third Affiliated Hospital of Harbin Medical University
2021
The deep and inner beds of solid tumors lack lymphocytic infiltration are subjected to various immune escape mechanisms. Reversing immunosuppression within the tumor is vital in clinical cancer therapy, however it remains a huge challenge. In this work, we have demonstrated use second window near-infrared (NIR(II)) photothermal treatment trigger more homogeneous deeper immunogenic cell death tumors, thereby eliciting both innate adaptive responses for control metastasis prevention....
While tumor-infiltrating cytotoxic T lymphocytes play a critical role in controlling tumor development, they are generally impotent an acidic microenvironment. Systemic treatment to neutralize acidity thus holds promise for the reversal of anergic state cells and improvement cell-associated immunotherapy. Herein, we report proof-of-concept RNAi nanoparticle-mediated therapeutic reversion restore antitumor functions potentiate checkpoint blockade therapy. Our strategy utilized vivo optimized...
Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway, is often deficient (MTAPdef) in tumors with 9p21 loss and hypothetically renders susceptible to synthetic lethality by antifolates targeting de novo purine synthesis. Here we report our single arm phase II trial (NCT02693717) that assesses pemetrexed MTAPdef urothelial carcinoma (UC) primary endpoint of overall response rate (ORR). Three 7 enrolled patients show (ORR 43%). Furthermore, a historic cohort...
Abstract Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex transported from endoplasmic reticulum (ER) to the Golgi apparatus where SREBP activated. Under cholesterol sufficient condition, Insigs act as anchor proteins retain in ER. However, of unknown. Here we report that a Golgi-localized membrane progestin adipoQ receptors 3 (PAQR3) interacts with Scap tethers them Golgi. PAQR3 promotes formation,...
Abstract FGFR3 alterations are observed in more than 15% of metastatic urothelial cancers. In 2019, erdafitinib was the first FGFR inhibitor approved by FDA for treatment FGFR3-altered cancer with an objective response rate 40%. However, a high percentage patients still do not respond to erdafitinib. Thus, it is critical identify additional biomarkers stratify and increase therapeutic efficacy inhibitors. Our previous study identified that frequently altered methylthioadenosine phosphorylase...
Abstract MTAP-deficiency in urothelial cancer is associated with poor clinical outcomes but correlates sensitivity to antifolate chemotherapy. This single-arm phase 2 trial (N=15) assessed the and biological effects of a sequential combination therapy using immune modulating agent pemetrexed anti-PD-L1 avelumab patients advanced resistant prior chemotherapy and/or immunotherapy. The regimen treatment resulted an overall response rate (ORR) 20% (95% CI: 5%, 42%), disease control (DCR) 47%...
Abstract Methylthioadenosine phosphorylase (MTAP) deficiency in urothelial cancer (UC) correlates with poor clinical outcomes and reduced response rates to immune checkpoint inhibitor (ICI) therapy. Understanding the mechanisms by which MTAP loss contributes ICI resistance identifying therapeutic strategies enhance efficacy MTAP-deficient tumors is of critical importance. Using CRISPR-Cas9, we deleted MB49 murine UC cell line established orthotopic bladder wild-type (WT) knock-out cells....
Objectives Obesity measurement indexes have certain screening value for metabolic diseases. To investigate associations between associated fatty liver disease (MAFLD) and obesity indexes, including traditional (BMI, WC, WHtR) new (ABSI, BRI, VAI, LAP), assess their ability. Methods 12,658 subjects aged 18-75 at the Health Center of a Class III Grade A Hospital were included, who divided into MAFLD non-MAFLD groups. Spearman’s rank correlation was used to study indexes. Receiver operating...
Rapid and accurate intraoperative pathological diagnosis (IOPD) is essential for decision-making to improve patients' outcomes avoid reoperations. In this study, using a NAD(P)H-activated fluorescent probe, multifunctional indicator has been developed selectively identify tumor cells from normal tissue achieve cancer grading identification. This rapid response CyQ-1, features unprecedented sensitivity toward NADH at low nanomolar levels under physiological conditions. Moreover, allows both...
Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic injury, which has the potential advance towards cirrhosis and hepatocellular carcinoma.
Consumption of vegetables rich in phenolic compounds has become a useful method to reduce the risk developing several types cancer. This study investigated potential relationship between alteration lettuce induced by reduced nitrogen supply and its anti-proliferative effects on Caco-2 colorectal cancer cells. Our results showed that extracts from grown under low conditions (LP) exhibited better against cells, part, interfering with cell cycle inducing apoptosis, compared those supplied...
Bioactive immunomodulatory biomaterials have shown promise for influencing the immune response to promote tissue repair and regeneration. Macrophages T cells been associated with this response; however, other cell types traditionally overlooked. In study, we investigated role of mast in regulation decellularized biomaterial scaffolds using a subcutaneous implant model. cell-deficient mice, there was dysregulation expected M1 M2 macrophage transition typically induced by scaffold....
The aim of the present study was to investigate protective mechanism underlying melatonin in severe acute pancreatitis (SAP). A total 64 male Sprague‑Dawley rats were randomly divided into four groups: sham operation (SO) group, SAP treatment (MLT) group and p38 inhibitor (SB203580) (SB) group. Acute induced by 5% taurocholate through retrograde infusion biliopancreatic ducts. SB203580 groups administered with MLT SB 30 min before induction SAP. Rats each euthanized at 6 12 h following...
This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection myoma (TCRM) on ovarian function, immune function quality sexual life patients with hysteromyoma. Two hundred forty hysteromyoma admitted into Second Affiliated Hospital Zhengzhou University from June 2014 2016 were divided group (LM group, n=120) (TCRM according random figure table. The difference between two surgical methods compared among different age in following aspects:...
Prevention of primary breast cancer (BCa) in women is great public health importance. The existing results from observational epidemiologic studies focused on the association between bisphosphonates and BCa risk have been inconsistent.To update this systematic review meta-analysis to assess effect risk.We comprehensively searched MEDLINE, EMBASE, Cochrane libraries, ProQuest, Web Science through June 25, 2018 for relevant studies.Epidemiological that assessed women.We reported according...