A5100702845- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- Liver Disease and Transplantation
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Acute Kidney Injury Research
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Acute Myocardial Infarction Research
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Effects of Radiation Exposure
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Organ Transplantation Techniques and Outcomes
- Abdominal vascular conditions and treatments
- Thyroid Cancer Diagnosis and Treatment
- Viral Infections and Immunology Research
- Tuberous Sclerosis Complex Research
Beijing Hospital of Traditional Chinese Medicine
2024
Capital Medical University
2024
University of Science and Technology of China
2019-2023
Xinxiang Medical University
2023
Jilin City Central Hospital
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2023
Sichuan University
2022
Kunming Medical University
2014-2022
First Affiliated Hospital of Kunming Medical University
2022
Dongguan People’s Hospital
2022
The deep and inner beds of solid tumors lack lymphocytic infiltration are subjected to various immune escape mechanisms. Reversing immunosuppression within the tumor is vital in clinical cancer therapy, however it remains a huge challenge. In this work, we have demonstrated use second window near-infrared (NIR(II)) photothermal treatment trigger more homogeneous deeper immunogenic cell death tumors, thereby eliciting both innate adaptive responses for control metastasis prevention....
Abstract The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), well vascular and interstitial barriers. To overcome abovementioned obstacles, we report a nano-pathogenoid (NPN) that can in situ hitchhike circulating neutrophils supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns native bacteria, NPNs are effectively...
Tumor cells undergoing immunogenic cell death (ICD) release damage-associated molecular patterns (DAMPs) to trigger a long-term protective antitumor response. ICD can be induced by certain pathogens, chemotherapeutics, and physical modalities. In this work, we demonstrate that gaseous molecule, specifically nitric oxide (NO), induce potent effect. NO exerts cytotoxic effects are accompanied the emission of DAMPs based on endoplasmic reticulum stress mitochondrial dysfunction pathways....
Sarcopenia remains poorly managed in clinical practice due to the lack of simple and accurate screening tools. This study aimed identify cutoff values SARC-F questionnaire Ishii's score using variables age, grip strength, calf circumference older inpatients China compare accuracy two methods explore their predictive ability for adverse outcomes (rehospitalization, falls, fracture, death). Hospitalized patients (n=138) aged ≥60 years were included. The tools was evaluated reference diagnosis...
A retrospective analysis is performed to determine if pre-treatment [18 F]-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) image derived parameters can predict radiation pneumonitis (RP) clinical symptoms in lung cancer patients.We retrospectively studied 100 non-small cell (NSCLC) patients who underwent FDG PET/CT imaging before initiation of radiotherapy (RT). Pneumonitis were evaluated using the Common Terminology Criteria for Adverse Events version...
Adoptively transferred natural killer T (NKT) cells confer distinct cancer surveillance without causing obvious side effects, making them a promising candidate for immunotherapy. However, their therapeutic efficacy is limited by inefficient tumor infiltration and inadequate activation in an immunosuppressive microenvironment. To overcome these obstacles, we develop strategy of using photothermal therapy (PTT) to promote the antitumor ability adoptively NKT cells. The are efficiently...
Dilated cardiomyopathy (DCM) is associated with sudden cardiac death and heart failure, resulting in a significant medical burden. The mechanisms underlying the pathogenesis of DCM remain elusive. In present study, human tissues from patients healthy donors were collected their pathology was examined. expression levels apoptosis regulator Bcl-2 fibrosis-associated microRNAs also evaluated. Extensive myocardial fibrosis observed. As demonstrated by western blotting, reverse...
Abstract Impaired antigen presentation either in dendritic cells (DCs) or tumor impedes the triggering of antitumor immunity cell killing, resulting failures multiple types cancer immunotherapy. Herein, strategy using dual‐targeting nanomedicines to simultaneously improve antigens by both DCs and is proposed. It shown that tuning surface charge nanoparticles (NPs) incorporating different amounts cationic lipids alters vivo NP tissue accumulation cellular targeting profiles. NPs with...
Recent studies have reported TIMs play an important role in tumors progression or regression, but the effect of biliary tract cancer remains unclear. The aim this study is to investigate prognostic value tumor infiltrating mast cells (TIMs) and its influence on gemcitabine-based adjuvant chemotherapy (ACT) benefits patients after surgery. were evaluated by immunohistochemical staining tryptase 250 with resected gallbladder carcinoma (GBC) extrahepatic bile duct (EBDC) from Zhongshan...
To assess the clinical characteristics and risk factors related to unfavorable prognosis of endometrioid ovarian carcinoma (EOVC) based on data from Surveillance, Epidemiology, End Results (SEER) database two centers in China.Data were extracted SEER China (2010 ~ 2021), 884 cases 87 patients with EOVC selected, respectively. Overall survival (OS) progression-free (PFS) compared among different groups using Kaplan-Meier analysis. The Cox proportional-hazards model was used identify...
Background: To explore the potential role of platelet/lymphocyte ratio (PLR) as a prognostic marker in septic patients with acute kidney injury (AKI) and to provide theoretical evidence for epidemiological study prognosis AKI its early stage. Methods: A pilot was conducted. logistic regression analysis conducted screen risk factors, selected factors were performed using multiple analysis; Receiver Operating Characteristic curve used determine optimal cutoff value PLR then calculate...
Background We aim to develop and validate a nomogram model for predicting severe acute kidney injury (AKI) after orthotopic liver transplantation (OLT).Methods A total of 576 patients who received OLT in our center were enrolled. They assigned the development validation cohort according time inclusion. Univariable multivariable logistic regression using forward variable selection routine applied find risk factors post-OLT AKI. Based on results analysis, was developed validated. Patients...
Abstract Background The purpose of this study was to investigate the effect hypothyroidism and thyroxine replacement therapy on prognosis nasopharyngeal carcinoma (NPC) patients. Methods clinical data 284 NPC patients, who received intensity‐modulated radiation (IMRT) between January 2011 December 2016, were retrospectively analyzed. Results Hypothyroidism occurred in 38% Patients with had significantly better disease‐free survival (DFS) ( p = 0.002) relapse‐free (RFS) 0.008). Multivariate...
Acute myocardial infarction and pulmonary embolism can have life-threatening consequences such as congestive heart respiratory failure, respectively. Cancer patients are at great risk of both acute complications because the malignancy sparks patient's blood hypercoagulable state. Nevertheless, literature currently offers only a few reports on associated with embolism, two them occurred in same cancer patient. Here, we present case 60-year-old woman who had been diagnosed lung cancer. She was...
To the Editor: Appropriate donor-to-recipient size matching is of crucial importance in lung transplantation. Although tailoring has been described as a successful means overcoming disparities, its merits and demerits remain unclear. Here, we present case recurrent hypoxemia after unmatched single The causes were right middle lobe resection consequential pulmonary trunk stenosis that lead to unbalanced ventilation–blood flow ratio, which was diagnosed by angiography properly treated...
Dialysis-requiring acute kidney injury (AKI-D) is a potentially serious complication associated with high in-hospital mortality among patients coronary artery disease (CAD) after angiography (CAG). Patients existing advanced (AKD) have an increased risk of developing AKI-D. However, few studies investigated the prognosis AKI-D in both CAD and AKD.
Choriocarcinoma is a highly malignant gynaecological tumour. This disease becomes life-threatening once brain haemorrhage or herniation occurs. Timely and accurate surgery can gain treatment time for patients that have large number of cerebral haemorrhages and/or herniation. current report describes case choriocarcinoma secondary to hydatidiform mole in 55-year-old woman presented with neurological symptoms. Following admission hospital, computed tomography examination found lung metastases...