A5102852465- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Pancreatic function and diabetes
- Cardiac Imaging and Diagnostics
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Peroxisome Proliferator-Activated Receptors
- Inflammatory Biomarkers in Disease Prognosis
- Drug Transport and Resistance Mechanisms
- Frailty in Older Adults
Guangdong Provincial People's Hospital
2020-2023
Guangdong Academy of Medical Sciences
2020-2023
South China University of Technology
2020-2023
Cardiovascular Institute of the South
2021
Guangdong General Hospital
2021
Inflammation and immune responses play an important role in the pathophysiology of contrast-associated acute kidney injury (CA-AKI), systemic inflammation index (SII) has recently emerged as a new parameter for inflammatory response evaluation. However, limited research been undertaken to explore relationship between SII CA-AKI following coronary angiography (CAG).From January 2007 December 2020, 46,333 patients undergoing CAG were included from 5 Chinese tertiary hospitals. was calculated...
Contrast-associated acute kidney injury (CA-AKI) is a major adverse effect of coronary angiography (CAG). Patients with chronic disease (CKD) and artery (CAD) are at high risk CA-AKI. This study aimed to investigate the association between prognostic nutritional index (PNI) CA-AKI in this high-risk population.This enrolled total 4,391 patients. was defined as serum creatinine increase ≥0.3 mg/dL or 50% from baseline within first 48 hours following CAG. The PNI calculated upon hospital...
Background: Post-contrast acute kidney injury (PC-AKI) is a severe complication of cardiac catheterization.Emerging evidence indicated that long non-coding RNAs (lncRNAs) could serve as biomarkers for various diseases.However, the lncRNA expression profile and potential in PC-AKI remain unclear.This study aimed to investigate novel early detection PC-AKI.Methods: tissues rats was evaluated through RNA sequencing.Potential were identified human-rat homology analysis, blood filtering verified...
Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) were identified targets for blood lipid management among coronary artery disease (CAD) patients. However, previous studies reported an inverse correlation between baseline LDL-C concentration clinical outcomes. This study aims to explore the definite association ApoB long-term prognosis.A total of 36,460 CAD patients admitted Guangdong Provincial People's Hospital enrolled categorized into two groups: high (≥65 mg/dL)...
Diabetes mellitus (DM) is a major risk factor for the development of heart failure (HF). Sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated consistent benefits in reduction hospitalization HF patients with DM. However, pharmacological mechanism not clear. To investigate mechanisms SGLT2 DM HF, we performed target prediction and network analysis by pharmacology method.We selected targets status from databases studies. The "Drug-Target" "Drug-Target-Disease" networks were...
Acute myocardial infarction (AMI), characterized by an event of necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms AMI remain largely elusive.A genome-wide association study dataset was obtained from CARDIoGRAMplusC4D project. A transcriptome-wide (TWAS) conducted using FUSION tool with gene expression references left ventricle and whole blood. Significant genes detected TWAS were subjected to Gene Ontology (GO) enrichment analysis. Then results integrated...
Background: Diabetes mellitus (DM) patients with increased urinary albumin creatinine ratio (uACR) have higher risk of mortality, while it is unclear in DM atherosclerotic cardiovascular disease (ASCVD). Methods: We analysed 2832 ASCVD this multi-center registry cohort study Cardiorenal ImprovemeNt II (CIN-II) 5 Chinese tertiary hospitals from 2007 to 2020. Patients were divided into 3 groups according their uACR level (normal group: < 30mg/g, moderately 30mg/g≤ 300mg/g, severely 300mg/g≤...
Background Chronic kidney disease (CKD) is very common in patients who are at a high risk of developing incident heart failure with reduced ejection fraction (HFrEF). However, the harmful effect CKD on HFrEF has not yet been examined among coronary artery (CAD) undergoing percutaneous intervention (PCI). Methods Patients PCI baseline left ventricular (LVEF) ≥ 40% were included from January 2007 to December 2018 ( ClinicalTrials.gov NCT04407936). We defined as follow-up LVEF &lt;40%...
The association between prothrombin time-international normalized ratio (PT-INR) and long-term prognosis among patients with coronary artery disease (CAD) without atrial fibrillation or anticoagulant therapy was still unclear. We analyzed the of PT-INR levels mortality in a large cohort CAD using drugs.We obtained data from 44,662 who were diagnosed had follow-up information January 2008 to December 2018. divided into 4 groups (Quartile 1: ≤ 0.96; Quartile2: 0.96 < 1.01; Quartile3: 1.01...
Background. Previous studies have shown that heart failure (HF) and chronic kidney disease (CKD) common genetic mechanisms, overlapping pathophysiological pathways, therapeutic drug—sodium-glucose cotransporter 2 (SGLT2) inhibitors. Methods. The pleiotropy metaCCA method was applied on summary statistics data from two independent meta-analyses of GWAS comprising more than 1 million people to identify shared variants pleiotropic effects between HF CKD. Targets SGLT2 inhibitors were predicted...
Purpose: Hypochloremia is a predictor for short-term mortality in patients with cardiovascular disease, but its association coronary artery disease (CAD) still unclear. We aimed to assess the impact of hypochloremia on all-cause (short-and long-term) among CAD. Patients and Methods: Based registry at Guangdong Provincial People's Hospital China, we analyzed data 49,025 hospitalized who underwent angiography (CAG) were diagnosed CAD from January 2007 December 2018. To between study endpoints,...
Background: Previous studies reported that patients with coronary artery disease (CAD) and well-controlled baseline LDL-C (&lt;1.8 mmol/L) still had higher long-term all-cause mortality. However, no study has been conducted to explore the independent risk factors for In addition, there also was evaluating population attributable (PAR) of in combination their prevalence relative risk. Therefore, we aimed identify estimate PAR CAD mmol/L). Methods: We analyzed 4,863 consecutive admitted...
Dialysis-requiring acute kidney injury (AKI-D) is a potentially serious complication associated with high in-hospital mortality among patients coronary artery disease (CAD) after angiography (CAG). Patients existing advanced (AKD) have an increased risk of developing AKI-D. However, few studies investigated the prognosis AKI-D in both CAD and AKD.
Different definitions of contrast-associated acute kidney injury (CA-AKI) have different predictive effects on prognosis. However, few studies explored the relationship between these and long-term prognosis in patients with congestive heart failure (CHF). Thus, we aimed to evaluate this association compared population attributable risks (PAR) CA-AKI definitions.This study enrolled 2,207 consecutive CHF undergoing coronary angiography (CAG) Guangdong Provincial People's Hospital. Two were...
Abstract BackgroundDiabetes mellitus (DM) is a major risk factor for the development of heart failure (HF). Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been demonstrated consistent benefits in reduction hospitalization HF patients with DM. However, pharmacological mechanism not clear. To investigate mechanisms SGLT2 on and DM, we performed target prediction network analysis by pharmacology method.Material/MethodsWe selected targets according to SwissTargetPrediction DrugBank...
Background: The regulatory effect of the left ventricular ejection fraction (LVEF) categories on association malnutrition and all-cause mortality in patients undergoing coronary angiography (CAG) have not been adequately addressed. Methods: Forty-five thousand eight hundred twenty-six consecutively enrolled Cardiorenal ImprovemeNt (CIN) study (ClinicalTrials.gov NCT04407936) from January 2008 to July 2018 who underwent (CAG). Controlling Nutritional Status (CONUT) score was applied 45,826...
Abstract Background Apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) was identified as the target for blood lipid management among coronary artery disease (CAD) patients. Previous studies reported an inverse correlation between baseline LDL-C concentration clinical outcomes. However, association ApoB long-term prognosis is unknown. Methods 36,486 CAD patients admitted to Guangdong Provincial People's Hospital in China were enrolled this study categorized into two...