A5101980667- Healthcare Systems and Public Health
- Gout, Hyperuricemia, Uric Acid
- Acute Kidney Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Biological and pharmacological studies of plants
- Biochemical Acid Research Studies
- Liver Disease and Transplantation
- Neurosurgical Procedures and Complications
- Healthcare and Venom Research
- Sirtuins and Resveratrol in Medicine
- Calpain Protease Function and Regulation
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Inflammasome and immune disorders
- Epilepsy research and treatment
- Traditional Chinese Medicine Studies
- Diabetes Treatment and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Organ Transplantation Techniques and Outcomes
Qingdao University
2008-2024
Affiliated Hospital of Qingdao University
2008-2024
Zhongnan Hospital of Wuhan University
2020
Wuhan University
2020
Clinical Research Institute
2020
Fudan University
2015
Zhongshan Hospital
2015
Durham University
2014
Baoding People's Hospital
2011
General Hospital of Guangzhou Military Command
2010
Our objective was to identify plasma biomarkers of ALS that can aid in distinguishing patients with from those disease mimics. In this multi-center study, samples were collected 172 recently diagnosed ALS, 50 healthy controls, and 73 neurological Samples analyzed using metabolomics. Using all identified biochemicals detected > 50% the metabolomics analysis, classified as or mimic 65% sensitivity 81% specificity by LASSO analysis (AUC 0.76). A subset panel 32 candidate these diagnosis groups...
Excitatory amino acid toxicity, oxidative stress, intracellular calcium overload, as well inflammation and apoptosis are involved in the pathological process after cerebral ischemic reperfusion injury. Picrodide 2 could inhibit neuronal play anti-oxidant anti-inflammation role ischemia/reperfusion injuries, but exact mechanism is not very clear. This study aims to explore of picroside injury rats. The middle artery occlusion models were established with intraluminal thread methods 90 adult...
Renal tubular epithelial cell (RTEC) death and renal interstitial inflammation are the most crucial pathophysiological changes in acute kidney ischemia/reperfusion injury (IRI). The microRNA (miR)-181d family plays diverse roles proliferation, apoptosis inflammation, but its target potential role IRI unknown. Here, we showed that expression of miR-181d-5p decreased a (HK-2) model hypoxia/reoxygenation (H/R) mouse IRI. Mechanistically, KLF6 was predicted as new gene through bioinformatic...
It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN usually accompanied by disordered intestinal flora, and damaged barrier, which are closely related tubulointerstitial fibrosis, systemic inflammation. In previous studies, it has confirmed curcumin could alleviate improve function through antioxidant, anti-apoptotic,...
Background We aim to develop and validate a nomogram model for predicting severe acute kidney injury (AKI) after orthotopic liver transplantation (OLT).Methods A total of 576 patients who received OLT in our center were enrolled. They assigned the development validation cohort according time inclusion. Univariable multivariable logistic regression using forward variable selection routine applied find risk factors post-OLT AKI. Based on results analysis, was developed validated. Patients...
ABSTRACT Purpose To present a case series of Cushing's syndrome (CS) during pregnancy caused by adrenocortical adenomas, highlighting clinical features, hormonal assessments and outcomes. Methods We describe five pregnant women with CS, detailing presentations laboratory findings. Results Common features included full moon face, buffalo back severe hypertension. Elevated blood cortisol levels circadian rhythm disruption suppressed adrenocorticotrophic hormone (ACTH) were observed. Imaging...
Background: Populations with normal high blood pressure often already have elevated uric acid levels and a higher chance of developing atherosclerosis, which accelerates the process cardiovascular disease. The risk atherosclerosis increases thickening carotid artery intima-media, changes in elasticity precede intima-media changes, so early monitoring is great significance prevention Using shear wave elastography (SWE) to evaluate effect serum (SUA) on patients high-normal (BP). Methods: One...
In the treatment of refractory epilepsy, especially in Dravet syndrome and Lennox-Gastaut syndrome, cannabidiol, an anticonvulsant component marijuana, has shown significant efficacy safety. However, its mechanism action interaction with other drugs are still unclear. For patients who have been treated a variety antiepileptic drugs, cannabidiol makes their more promising but also complicated. This review focuses on clinical research progress epilepsy. Key words:...
Introduction: The relationship between atrial fibrillation (AF) burden and the risk of adverse outcomes is incompletely understood. Methods: In a longitudinal cohort study patients with clinical history non-permanent AF who underwent new implantation an Abbott cardiac implantable electronic device (CIED) 2010 2016, we linked Merlin.net TM remote-monitoring data Medicare claims to assess association device-detected (daily percentage in AF) all-cause mortality, hospitalization, cardiovascular...