A5011775905- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Congenital Anomalies and Fetal Surgery
- Access Control and Trust
- Global trade and economics
- Hippo pathway signaling and YAP/TAZ
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Lipid metabolism and biosynthesis
- Wnt/β-catenin signaling in development and cancer
- Cardiovascular Issues in Pregnancy
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Adrenal and Paraganglionic Tumors
- Cancer Cells and Metastasis
- Pituitary Gland Disorders and Treatments
- Regional Economic and Spatial Analysis
- Fibroblast Growth Factor Research
- Business Process Modeling and Analysis
- Congenital Diaphragmatic Hernia Studies
Affiliated Hospital of Qingdao University
2019-2024
Qingdao University
2019-2024
China University of Political Science and Law
2011
Beijing Institute of Technology
2008
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). To understand how AD-MSCs regulated trophoblast function, we treated trophoblasts with AD-MSC-derived exosomes under hypoxic conditions. The markedly enhanced proliferation and autophagy. Furthermore, significant decrease EZH2 levels inactivation mTOR signaling...
As shown in our previous studies, growth and metastasis of ovarian cancer can be regulated by adipose-derived mesenchymal stem cells (ADSCs). However, the underlying mechanism has not yet been revealed. In this study, a proteomics analysis was performed to compare protein expression treated with without ADSCs cells. Protein levels were altered due treatment ADSCs. Thymosin beta 4 X-linked (TMSB4X) changed dramatically, identified as one most important candidate molecules contributing...
Abstract Our previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed. In this study, an RNA‐seq approach was adopted compare differences in mRNA levels cancer being given or not ADSCs. The level paired box 8 (PAX8) changed significantly confirmed as important factor tumour‐inducing effect comparison with cultured common growth medium, those...
ABSTRACT Purpose To present a case series of Cushing's syndrome (CS) during pregnancy caused by adrenocortical adenomas, highlighting clinical features, hormonal assessments and outcomes. Methods We describe five pregnant women with CS, detailing presentations laboratory findings. Results Common features included full moon face, buffalo back severe hypertension. Elevated blood cortisol levels circadian rhythm disruption suppressed adrenocorticotrophic hormone (ACTH) were observed. Imaging...
Preeclampsia (PE) is a severe pregnancy complication that accounts for about 14% of maternal deaths. Its clinical manifestations commonly include hypertension and proteinuria. However, it largely limited in understanding its pathogenetic mechanism. In this study, we used bioinformatics to compare differential gene expressions decidual stromal cells from PE patients healthy donors. The result indicated higher levels CCL5 CXCL2 were expressed compared with pregnancy. analysis confirmed derived...
Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function. To understand how trophoblast function, we treated with CV-MSC supernatant under hypoxic conditions. Treatment markedly enhanced proliferation and invasion augmented autophagy. Transcriptome pathway analyses of before after treatment JAK2/STAT3 signalling as an upstream regulator....
With the proliferation of researches on web services and their increasing applications in industries comes opportunity to study analysis design method service-based systems systematically. Our objective is propose a for modeling conduct practice developing application systems. In this paper, we introduce relevant research services. We also present Petri net theory take it as theoretical foundation method. Next, assess correctness model constructed by Finally, case airport emergency...
Human chorionic villous mesenchymal stem cells (CV-MSCs) are a promising and effective therapeutic option for tissue injury. Vascular dysfunction during pregnancies is significantly involved in the pathogenesis of preeclampsia (PE). This work aims to investigate how CV-MSCs regulate function vascular endothelial cells. In this study, RNA-seq analysis was used examine changes HUVECs treated with CV-MSC conditioned medium (CM). We examined levels ABCA9 AKT signaling human umbilical vein...
Preeclampsia, a significant cause of maternal and perinatal morbidity mortality, remains poorly understood, in terms its pathogenesis. This study aims to uncover novel effective biomarkers for preeclampsia by conducting comparative analysis differential proteins placentas from early onset (EOPE) normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed placental tissues 15 EOPE patients pregnant women. These were subsequently...
Objective. To explore the effect of Yiqi Buxue decoction on hemodynamic changes uterine artery and fetal umbilical pregnancy outcomes in pregnant patients with pulmonary arterial hypertension (PAH). Methods. 120 PAH treated our hospital (January 2019-January 2020) were chosen as research objects, randomly split into group A (n = 60) B 60). Both groups received routine treatment, was sildenafil citrate, while combined citrate. 6 weeks treatment to analyze compare cardiopulmonary function...
Adopting distributed lag model and econometrics method, the paper tested impacts of Japan US FDI on China's industrial structure upgrading, employment technology advancement. The result suggested that had contributed more to economy than in terms quantity, while played significant role economic optimization from perspective quality. In long run, lagged effects both United States three major industries have been weakened, but at different speeds.
Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. To understand how human chorionic villous mesenchymal stem cells (CV-MSCs) operate regulation of trophoblast function, we treated trophoblasts with CV-MSC supernatant under hypoxic conditions. The treatment markedly enhanced proliferation and invasion ability augmented autophagy. Transcriptome pathway analyses before after revealed JAK2/STAT3 signalling as an upstream regulator. We further found that STAT3...
Abstract ObjectiveIt is found that human chorionic villous mesenchymal stem cells (CV-MSCs) are a promising and effective treatment for tissue injury. Trophoblast dysfunction during pregnancies obviously entangles to the pathogenesis of preeclampsia (PE). This work was make it clear how CV-MSCs regulated vascular endothelial cell function. MethodsIn this study, we treated HUVEC with CV-MSC CM RNA-seq analysis used understand changes in HUVEC. We examined levels ABCA9 AKT signaling by...
Abstract Objectives Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. The aim of this study was to understand how human chorionic villous mesenchymal stem cells (CV-MSCs) operate regulation trophoblast function. Materials and Methods We treated trophoblasts with CV-MSC supernatant under hypoxic conditions, transcriptome pathway analyses were performed. Western blotting PCR analysis used examine the JAK2, STAT3 autophagy associated protein expression levels...
Abstract Objectives Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. The aim of this study was to understand how human chorionic villous mesenchymal stem cells (CV-MSCs) operate regulation trophoblast function.Materials and Methods We treated trophoblasts with CV-MSC supernatant under hypoxic conditions, transcriptome pathway analyses were performed. Western blotting PCR analysis used examine the JAK2, STAT3 autophagy associated protein expression levels...