A5105672410- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Maternal and fetal healthcare
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Gene expression and cancer classification
- Ectopic Pregnancy Diagnosis and Management
- Food composition and properties
- Orthopedic Infections and Treatments
- Diet and metabolism studies
- Extracellular vesicles in disease
- Spinal Fractures and Fixation Techniques
- Peroxisome Proliferator-Activated Receptors
- Advanced Glycation End Products research
- Spine and Intervertebral Disc Pathology
- Skin Protection and Aging
- Air Quality and Health Impacts
- Cervical and Thoracic Myelopathy
- Single-cell and spatial transcriptomics
- Cell Adhesion Molecules Research
- Developmental Biology and Gene Regulation
- Stress Responses and Cortisol
- Fetal and Pediatric Neurological Disorders
Affiliated Hospital of Qingdao University
2014-2024
Qingdao University
2014-2024
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2021-2024
Sanford Consortium for Regenerative Medicine
2023
University of California, San Diego
2023
Ningbo University
2023
Nanfang Hospital
2021
Southern Medical University
2021
University of South Carolina
2020
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). To understand how AD-MSCs regulated trophoblast function, we treated trophoblasts with AD-MSC-derived exosomes under hypoxic conditions. The markedly enhanced proliferation and autophagy. Furthermore, significant decrease EZH2 levels inactivation mTOR signaling...
Extracellular vesicles (EVs) can mediate intercellular communication, including signaling between the placenta and maternal tissues. Human placental explant culture is a versatile
<b><i>Background:</i></b> Previous studies have shown that oxidative stress is an important factor in preeclampsia (PE). Heme oxygenase-1 (HO-1) and nuclear erythroid 2-related factor-2 (Nrf2) are protective proteins involved combating the body. Nrf2 also essential upstream transcription regulating HO-1. This study was aimed at exploring physiological roles of HO-1 PE. <b><i>Methods:</i></b> Serum placenta were collected from 30 patients who...
Objective To evaluate mid‐ to long‐term results of revision total hip arthroplasty for massive femoral bone loss using a cementless modular, fluted, tapered stem. Methods This is retrospective study performed at single hospital. During the period January 2007 2015, 33 patients (34 hips) underwent primary surgery with stems due loss. Sixteen men and 17 women were included in study, an average age 63.9 ± 11.7 years (range, 27 88 years). Operative data including operative duration, length...
Objective: To determine whether maternal plasma human placental lactogen (hPL) mRNA levels can predict abnormally invasive placenta. Study design: Sixty-eight singleton pregnant women with prior Cesarean deliveries were classified into three groups: 35 normal placentation (control group); 21 placenta previa alone (placenta 12 and accreta group). Maternal hPL concentrations measured by real-time reverse-transcription polymerase chain reaction Result: The multiple of the median (median, range)...
Abstract Background Patients with abnormally invasive placenta (AIP) are at high risk of massive postpartum hemorrhage. Resuscitative endovascular balloon occlusion the aorta (REBOA), as an adjunct therapeutic strategy for hemostasis, offers obstetrician alternative treating patients AIP. This study aimed to evaluate role REBOA in hemorrhage control Methods was a historical cohort prospectively collected data between January 2014 July 2021 single tertiary center. According delivery...
ABSTRACT The purpose of this study was to determine the sex differences in overall prevalence radiographic femoroacetabular impingement (FAI) deformity patients presenting with hip pain and identify most common findings male female patients. A geographic database used between age 14 50 years from 2000 2016. chart review performed cam, pincer mixed-type FAI. total 374 (449 hips) out 612 (695 771 (922 1281 (1447 had features consistent Ninety-four hips (20.9%) 45 (4.9%) cam type, 20 (4.5%) 225...
The adjusted mechanical alignment (aMA) technique is an extension of conventional (MA), which has rarely been reported. purpose this study was to evaluate mid-term outcomes navigation-assisted total knee arthroplasty (TKA) using aMA.This retrospective cohort enrolled 63 consecutive patients (77 knees) who underwent TKA aMA between September 2017 and October 2019. Fifty-two (61 MA during the same period were assessed as controlled group. demographic data perioperative recorded. parameters...
Our previous work showed that resistant starch (RS) failed to reduce obesity in rodents fed a high fat diet. The diet (41% dietary energy) prevented fermentation of RS and reduced bacterial populations the gut compared low (18% energy). current 10‐wk study used thirty‐six C57Bl/6J mice determine effects with vs. moderate diets 28% on growth populations. We measured three types bacteria involved butyrate production. was analyzed as 2x2 factorial control versus (significance at p<0.05)....
Preeclampsia, a significant cause of maternal and perinatal morbidity mortality, remains poorly understood, in terms its pathogenesis. This study aims to uncover novel effective biomarkers for preeclampsia by conducting comparative analysis differential proteins placentas from early onset (EOPE) normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed placental tissues 15 EOPE patients pregnant women. These were subsequently...
Abstract This study aimed to explore the feasibility and clinical effectiveness of a combined transoral endoscopic approach for removal benign cervical spine tumors. First, we obtained detailed anatomical measurements atlantoaxial joint from 20 fresh cadaveric specimens performed simulated surgeries with on 10 specimens. Then, applied resection tumors in 8 patients at our hospital October 2013 2015. All underwent enhanced axial, coronal, sagittal computed tomography (CT) examination before...
Summary The current spreading novel coronavirus SARS-CoV-2 is highly infectious and pathogenic. In this study, we screened the gene expression of three host receptors (ACE2, DC-SIGN L-SIGN) DC status in bulk single cell transcriptomic datasets upper airway, lung or blood smokers, non-smokers COVID-19 patients. We found smoking increased inhibited maturation its ability T stimulation. COVID-19, was interestingly decreased DCs but DCs. Strikingly, shifted from cDCs to pDCs shift trapped an...
Objective To investigate the effect of pre-ischemia physical activity on cognition and ascorbate content in medial prefrontal cortex (mPFC) after cerebral ischemia.Methods Twenty-four Sprague-Dowley rats were enrolled this study randomly divided into following 4 groups:running-ischemia group,running group,ischemia group shame operation group.Cerebral ischemia was brought about by permanent 2 vessels occlusion (2-VO) method.Treadmill running used as training.Ascorbate mPFC monitored with vivo...
Microorganisms in the human gut reach 10 to 100 trillion, and their metabolic activities impact health. Resistant starch (RS) is a fermentable fiber which promotes fermentation lower gut. This study investigated how RS impacts microbial community structure. We characterized microflora mice fed dietary using molecular approaches. Total bacterial DNA was isolated from cecal contents of 2 groups (n=3) or an equal energy density diet. 16S rRNA amplified by PCR, cloned, randomly selected clones...
This study aimed to investigate the protective mechanism of Acaudina leucoprocta peptides (ALPs) in kidney type II diabetes mice (db/db mice). Serum lipid and glucose indexes were detected after ALPs treatment. The two-dimensional gel electrophoresis was used protein diabetic mice. differential screening, GO function annotation, metabolic pathways determine symptoms db/db alleviated 10 weeks treatment with ALPs. content TC, TG, LDL-C group significantly decreased level HDL-C increased. After...