A5100675827- Gut microbiota and health
- Diet and metabolism studies
- Protein Hydrolysis and Bioactive Peptides
- Trace Elements in Health
- Gout, Hyperuricemia, Uric Acid
- Fatty Acid Research and Health
- Biochemical effects in animals
- Metabolomics and Mass Spectrometry Studies
- Microbial Natural Products and Biosynthesis
- Iron Metabolism and Disorders
- Bacterial biofilms and quorum sensing
- Osteoarthritis Treatment and Mechanisms
- Echinoderm biology and ecology
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- Peptidase Inhibition and Analysis
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Plant Micronutrient Interactions and Effects
- Diet, Metabolism, and Disease
- Polyamine Metabolism and Applications
- Tryptophan and brain disorders
- Parasitic Infections and Diagnostics
- MicroRNA in disease regulation
Ningbo University
2017-2024
West China Hospital of Sichuan University
2019-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sichuan University
2019-2024
Zhejiang Gongshang University
2023-2024
Tianjin Chengjian University
2024
Sun Yat-sen University
2024
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Purdue University West Lafayette
2023
Hyperuricemia is an important risk factor for many diseases including hypertension and type 2 diabetes. This study investigated compared the effects of hydrolysates two sea cucumber species, Apostichopus japonicus Acaudina leucoprocta, on alleviation diet-induced hyperuricemia renal inflammation. The structure abundance oligopeptides in enzymatic A. (EH-JAP) leucoprocta (EH-LEU) were identified via MALDI-TOF/TOF-MS, anti-hyperuricemic anti-inflammatory explored a hyperuricemic mouse model....
Recently, interest in using whole food-derived mixtures to alleviate chronic metabolic syndrome through potential synergistic interactions among different components is increasing. In this study, the effects and mechanisms of tuna meat oligopeptides (TMOP) on hyperuricemia associated renal inflammation were investigated mice. Dietary administration TMOP alleviated phenotypes, reprogramed uric acid metabolism pathways, inhibited activation NLRP3 inflammasome TLR4/MyD88/NF-κB signaling...
Urolithin A (UroA) is a microbial metabolite derived from ellagitannins and ellagic acid with good bioavailability. In this study, we explored the anticolitis activity of UroA clarified mechanism by 16S rDNA sequencing metabonomics. alleviated dextran sulfate sodium (DSS)-induced colitis in mice, characterized decreased disease index, increased colon length, improved colonic histopathological lesions, along inhibited phosphorylation mitogen-activated protein kinase signaling pathway....
Previous studies confirmed that dietary supplements of fish oil and krill can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether treatment change structure gut microbiota during alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two acclimatization with a standard chow diet, fed were used as control. In groups HFD supplementation, weight gains attenuated liver index, total cholesterol, triglyceride...
Hyperuricaemia is a disease associated with elevated serum uric acid content, which has emerged rapidly in recent decades. The drugs used to treat clinical hyperuricaemia have side effects, and their safety poor. However, anserine natural carnosine derivative that shows an anti-hyperuricaemic effect. A previous study demonstrated inhibits synthesis promotes excretion, but there no evidence regarding the effect of from perspective gut microbiota. In this study, anti-inflammatory effects were...
Abstract Depression is common in patients with rheumatoid arthritis (RA); however, the precise mechanisms underlying a link between depression and RA remain unclear. Accumulating evidence suggests role of gut–microbiota–brain axis depression. In this study, we investigated whether collagen-induced (CIA) mice produce depression-like behaviors abnormal composition gut microbiota. Furthermore, fecal microbiota transplantation (FMT) from causes phenotypes antibiotic cocktail (ABX)-treated mice....
Staphylococcus aureus (S. aureus) has a strong tolerance to high salt stress. It is major reason as why the contamination of S. in salted food cannot be eradicated. To elucidate its response and survival mechanisms, changes morphology, biofilm formation, virulence, transcriptome, metabolome were investigated. IsaA positively regulates participates formation biofilm. Virulence was downregulated reduce depletion nonessential cellular functions. Inositol phosphate metabolism conversion...
Streptomyces hygroscopicus 5008 has been used for the production of antifungal validamycin/jinggangmycin more than 40 years. A high yield validamycin is achieved by culturing strain at 37°C, rather 30°C normal growth and sporulation. The mechanism(s) its thermo-regulated biosynthesis was largely unknown.The 10,383,684-bp genome completely sequenced composed a linear chromosome, 164.57-kb plasmid, 73.28-kb circular plasmid. Compared with other genomes, chromosome smaller core region shorter...
Paired homologs of γ-butyrolactone (GBL) biosynthesis gene afsA and GBL receptor arpA are located at different positions in genome Streptomyces hygroscopicus 5008. Inactivation dramatically decreased validamycin, an important anti-fungal antibiotic a critical substrate for antidiabetic drug synthesis, the deletion increased validamycin production by 26% (ΔshbR1) 20% (ΔshbR3). By double deletion, ΔshbR1/R3 mutant showed higher transcriptional levels adpA-H (the S. ortholog global regulatory...
Multiple lines of evidence suggest that the gut microbiota plays vital roles in metabolic diseases such as hyperlipidemia. Previous studies have confirmed krill oil can alleviate hyperlipidemia, but underlying mechanism remains unclear. To discern whether changes structure during hyperlipidemia treatment, 72 mice were acclimatized with a standard chow diet for 2 weeks and then randomly allocated to receive (control group, n = 12) or high-sugar-high-fat (HSHF) supplemented low (100 μg/g·d,...
Studies have documented the benefits of fish oil in different diseases because its high n-3 polyunsaturated fatty acid content. However, these studies mostly used commercially available supplements with a ratio 18/12 for eicosapentaenoic and docosahexaenoic (DHA). increasing DHA content this commonly might bring out varied metabolic effect, which remained unclear. Thus, study, novel tuna (TO) was applied to investigate effect high-DHA on alteration gut microbiota obesity high-fat diet mice....
Scope The effects and mechanism of tuna bone powder (TBP) on glucocorticoid‐induced osteoporosis (GIOP) alleviation in terms signaling pathway coregulation gut microbiota modulation are investigated. Methods results size distribution composition TBP measured. GIOP female mice induced by dexamethasone intramuscular injection used to examine the anti‐osteoporosis a 10 week experiment, improved mineral density microarchitecture observed via micro‐CT. In addition, qRT‐PCR show that NF‐κB is...
Hyperuricemia (HUA) is the second most common metabolic disease nowadays, and characterized by permanently increased concentrations of serum uric acid. In this study, two novel hexapeptides (GPAGPR GPSGRP) were identified from Apostichopus japonicus hydrolysate predicted to have xanthine oxidase (XOD) inhibitory activity molecular docking. Their in vitro XOD inhibition rates reached 37.3% 48.6%, respectively, at a concentration 40 mg mL-1. Subsequently, vivo experiments carried out HUA mouse...
The soluble variant of the ectopeptidase CD13 (sCD13), released from cell surface by matrix metalloproteinase 14 (MMP14), is a potent pro-inflammatory mediator, displaying chemotactic, angiogenic, and arthritogenic properties through bradykinin receptor B1 (B1R). We reveal link between sCD13 amplified neutrophil-mediated inflammatory responses in SARS-CoV-2 infection. was markedly elevated COVID-19 patients correlated with disease severity, variants, ethnicity, inflammation markers, NETosis....
Lactobacillus plantarum, a versatile lactic acid-fermenting bacterium, isolated from the traditional pickles in Ningbo of China, was chosen for grass carp fermentation, which could also improve flavor carp. We here explored central metabolic pathways L. plantarum by using metabolomic approach, and further proved potential metabolomics combined with proteomics approaches basic research on changes metabolites corresponding fermentation mechanism fermentation. This study provides cellular...
Initiation of DNA replication by phage lambda requires the ordered assembly and disassembly a specialized nucleoprotein structure at origin replication. In pathway, set Escherichia coli heat shock proteins termed Hsp70 complex--DnaK, DnaJ, GrpE--act with ATP to release P protein from nucleo-protein complex, freeing DnaB helicase for its DNA-unwinding reaction. To investigate mechanism reaction, we have examined interaction between three glycerol gradient sedimentation gel electrophoresis. We...
This study aims to investigate the protective effect of Apostichopus japonicus oligopeptide (AJOP) on hyperuricemia, demonstrate modulation gastrointestinal tract (GIT) microbiota, and clarify underlying microbiota-dependent mechanism.Hyperuricemic mice treated with AJOP subjected corresponding fecal microbiota transplantation (FMT) are used observe beneficial effects microbiota. Gene transcriptions measured using quantitative real-time PCR. The GIT (stomach, colon, cecum, feces) is analyzed...