A5100330583- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
- Chronic Myeloid Leukemia Treatments
- Inflammasome and immune disorders
- Acute Myeloid Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Ocular Oncology and Treatments
- Hematopoietic Stem Cell Transplantation
- Clostridium difficile and Clostridium perfringens research
- Ocular Diseases and Behçet’s Syndrome
- Multiple Myeloma Research and Treatments
- Autoimmune and Inflammatory Disorders Research
- Glaucoma and retinal disorders
- Cancer-related Molecular Pathways
- Retinal Diseases and Treatments
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Psoriasis: Treatment and Pathogenesis
- Platelet Disorders and Treatments
- Intraocular Surgery and Lenses
- Immune Response and Inflammation
- Retinal and Optic Conditions
National Institutes of Health
2025
Center for Cancer Research
2025
National Cancer Institute
2025
Jilin University
2023-2025
Liaoning University of Traditional Chinese Medicine
2023-2025
Qingdao University of Science and Technology
2024-2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Chengdu Medical College
2024
Deyang Stomatological Hospital
2024
The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or mutations nucleophosmin (NPM1) gene. As step toward clinical translation menin-MLL1 inhibitors, we report development MI-3454, highly potent orally bioavailable inhibitor interaction. MI-3454 profoundly inhibited proliferation induced differentiation cells primary patient samples NPM1 mutations. When applied as single agent,...
Abstract Background COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to diseases such as influenza, little known about the role of in pathophysiology. Methods To better understand host-gut interactions COVID-19, we microbial community barrier function using metagenomic metaproteomic approaches 63 patients 8 non-infected controls. Both...
Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related macular degeneration (AMD), one of the first batch most successful examples genome-wide association study. However, to date focused on case-control late AMD (choroidal neovascularization or geographic atrophy). The influences disease progression are largely unexplored. We assembled unique resources perform a bivariate time-to-event analysis test time-to-late-AMD with...
Oral microbial dysbiosis is known to increase susceptibility of an individual develop rheumatoid arthritis (RA). Individuals at-risk RA may undergo different phases disease progression. In this study, we aim investigate whether and whereby the oral microbiome communities alter prior symptoms RA. 79 saliva samples were collected from 29 high-risk individuals, who positive for anti-citrullinated protein antibodies (ACPA) have no clinical arthritis, 27 patients 23 healthy controls (HCs). The...
Obesity, a chronic low-grade inflammatory state, not only promotes bone loss, but also accelerates cell senescence. However, little is known about the mechanisms that link obesity, and Interleukin-6 (IL-6), pivotal mediator increased during candidate for promoting senescence an important part of senescence-associated secretory phenotype (SASP). Here, wild type (WT) (IL-6 KO) mice were fed with high-fat diet (HFD) 12 weeks. The results showed IL-6 KO gain less weight on HFD than WT mice....
Objective In this study, we aimed to decipher the gut microbiome (GM) and serum metabolic characteristic of individuals at high risk for rheumatoid arthritis (RA) investigate causative effect GM on mucosal immune system its involvement in pathogenesis arthritis. Methods Fecal samples were collected from 38 healthy 53 high‐risk RA with anti–citrullinated protein antibody (ACPA) positivity (Pre‐RA), 12 Pre‐RA developed within 5 years follow‐up. The differences intestinal microbial composition...
Abstract Objective To evaluate the efficacy and safety of telitacicept in adult patients with primary SS (pSS) a phase II randomized double-blind placebo-controlled trial. Methods Patients pSS positive anti-SSA antibody ESSDAI ≥ 5 were randomly assigned, 1:1:1 ratio, to receive weekly subcutaneous 240 mg, 160 or placebo for 24 weeks. The end point was change from baseline at week 24. Safety monitored. Results A total 42 enrolled (n = 14 per group). Administration mg resulted significant...
This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort SLE-associated PAH was established. Baseline follow-up records were collected. The primary end-point death. secondary exploratory treatment goal achievement (TGA), defined as an integrated outcome.In total, 310 enrolled from 14 centres....