A5101404982- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Supramolecular Self-Assembly in Materials
- Fluoride Effects and Removal
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Bone and Dental Protein Studies
- Research in Cotton Cultivation
- 3D Printing in Biomedical Research
- Diet, Metabolism, and Disease
- Dendrimers and Hyperbranched Polymers
- Connective tissue disorders research
- Bone Metabolism and Diseases
- Fungal and yeast genetics research
- Plant biochemistry and biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Dental Implant Techniques and Outcomes
- Plant Virus Research Studies
- Enzyme Structure and Function
- Telomeres, Telomerase, and Senescence
- Blood groups and transfusion
- Ocular Oncology and Treatments
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
University of California, Berkeley
2020-2024
Sichuan University
2017-2021
West China Hospital of Sichuan University
2021
Capital Medical University
2021
Ministry of Industry and Information Technology
2021
Beijing Tongren Hospital
2021
Shaanxi Provincial People's Hospital
2021
Shanxi Medical University
2021
Union Hospital
2020
Nankai University
2013-2018
Obesity, a chronic low-grade inflammatory state, not only promotes bone loss, but also accelerates cell senescence. However, little is known about the mechanisms that link obesity, and Interleukin-6 (IL-6), pivotal mediator increased during candidate for promoting senescence an important part of senescence-associated secretory phenotype (SASP). Here, wild type (WT) (IL-6 KO) mice were fed with high-fat diet (HFD) 12 weeks. The results showed IL-6 KO gain less weight on HFD than WT mice....
Abstract Adipose tissue stores triacylglycerol (TAG) in lipid droplets (LD) and release fatty acids upon lipolysis during energy shortage. We identify ApoL6 as a LD-associated protein mainly found adipose tissue, specifically adipocytes. expression is low fasting but induced feeding. knockdown results smaller LD with lower TAG content adipocytes, while overexpression causes larger higher content. show that the affects adipocytes through inhibition of lipolysis. While ApoL6, Perilipin 1...
Abstract The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex (Paf1C), which is composed of at least five subunits (Paf1, Leo1, Ctr9, Cdc73, and Rtf1), plays vital roles in gene regulation has connections to development human diseases. Here, we report two structures each the yeast Ctr9/Paf1 subcomplexes, assemble into heterodimers with very similar conformations, revealing an interface between tetratricopeptide repeat module Ctr9 Paf1. structure...
Here we reported a novel biohybrid hydrogel system with the potential for cell culture and controlled drug release.
A hetero‐hexameric protein system is developed in this study, which not only functions as cross‐linkers for hydrogel formation but also offers docking sites controlled delivery of bioactive molecules. First, a hexameric with two, four, and six tax‐interacting protein‐1 (TIP‐1), respectively (named 2T, 4T, 6T), designed obtained. As the hexapeptide ligand (WRESAI) can specifically bind to TIP‐1 high affinity, proteins 6T be used crosslink self‐assembling nanofibers Nap‐GFFYGGGWRESAI, leading...
Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical energy into heat, thereby increasing expenditure. Here, we identify Dot1l, the only known H3K79 methyltransferase, as an interacting partner Zc3h10 that transcriptionally activates Ucp1 promoter and other BAT genes. Through direct interaction, Dot1l recruited by to regions thermogenic genes function coactivator methylating H3K79. We also show induced during brown fat cell differentiation cold exposure...
To compare the effects of high-fat diet (HFD) and high-fructose (HFrD) on bone metabolism at different time points, dynamically observe histology femur trabecular micro-architecture, analyze underlying mechanisms.
To explore the molecular basis for an individual with Bel subtype of ABO blood type due to a novel c.620T>C variant gene, and assess its impact on structure GTB transferase.
Objective To explore the effect of excessive fluoride on expression mRNA and protein Wnt3a β-catenin in rats' osteoblasts its correlation with pathogenic mechanism fluorosis.Methods Thirty-six healthy SD rats,weighting 100-120 g according to body mass,were randomly divided into three groups(twelve each group).The rats control were fed wich tap water(fluoride ＜ 1 mg/L) experimental exposed NaF(low-fluoride group:5 mg/L,high-fluoride group:50 added drinking water establish chronic fluorosis...
The present study screened the structural mutations of retinoblastoma (RB1) gene using capture and a preliminary exploration correlation between genotypes phenotypes. A total 45 formalin-fixed paraffin-embedded (FFPE) tissue samples 12 peripheral venous blood from patients with (RB) confirmed by pathological examination at Beijing Tongren Hospital were collected May 2019 2021. DNA was extracted, sequenced, analyzed to detect in RB1 designing targeted probes for exons flanking sequences gene....
ABSTRACT Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical energy into heat, thereby increasing expenditure. Here, we identify Dot1L, the only known H3K79 methyltransferase, as an interacting partner Zc3h10 that transcriptionally activates UCP1 promoter and other BAT genes. Through direct interaction, Dot1L recruited by to regions thermogenic genes function coactivator methylating H3K79. We also show induced during brown fat cell differentiation cold...
ABSTRACT ApoL6 is a new LD-associated protein containing an apoprotein-like domain, expressed mainly in adipose tissue, specifically adipocytes. expression low fasting but induced upon feeding. knockdown results smaller LD with lower triglyceride (TAG) content adipocytes, while overexpression causes larger higher TAG content. We show that effect adipocytes by inhibition of lipolysis. While ApoL6, Perilipin 1 (Plin1) and HSL can form complex on LD, C-terminal domain directly interacts Plin1,...