A5102940439- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Antioxidant Activity and Oxidative Stress
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Cardiovascular Health and Risk Factors
- Ophthalmology and Visual Impairment Studies
- Retinoids in leukemia and cellular processes
- Ocular Oncology and Treatments
- Nutritional Studies and Diet
- Complement system in diseases
- Intraocular Surgery and Lenses
- Biochemical effects in animals
- Cerebrovascular and genetic disorders
- Barrier Structure and Function Studies
- Drug-Induced Ocular Toxicity
- Connexins and lens biology
- CNS Lymphoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- melanin and skin pigmentation
Oregon Health & Science University
2012-2024
Legacy Health
2008-2014
National Eye Institute
2014
Ophthalmology Associates (United States)
2007
Imperial College London
2001
Research to Prevent Blindness
1997
Johns Hopkins University
1976
<b>Purpose:</b> To evaluate the efficacy of macular grid photocoagulation in preserving or improving central visual acuity eyes with edema due to vein occlusion (CVO) and best-corrected 20/50 poorer. <b>Methods:</b> Patients angiographically documented CVO were entered into a multicenter randomized controlled clinical trial supported by National Eye Institute. Eligibility was determined based on both examination findings photographic documentation evaluated at photograph reading center. Eyes...
<h3>Importance</h3> The Age-Related Eye Disease Study (AREDS) formulation for the treatment of age-related macular degeneration (AMD) contains vitamin C, E, beta carotene, and zinc with copper. 2 (AREDS2) assessed value substituting lutein/zeaxanthin in AREDS because demonstrated risk lung cancer from carotene smokers former lutein zeaxanthin are important components retina. <h3>Objective</h3> To further examine effect supplementation on progression to late AMD. <h3>Design, Setting,...
Twenty-eight patients with advanced neovascular age-related macular degeneration (AMD) were given a single intravitreous injection of an E1-, partial E3-, E4-deleted adenoviral vector expressing human pigment epithelium- derived factor (AdPEDF.11). Doses ranging from 106 to 109.5 particle units (PU) investigated. There no serious adverse events related AdPEDF.11 and dose-limiting toxicities. Signs mild, transient intraocular inflammation occurred in 25% patients, but there was severe...
To report the change in visual acuity and central retinal thickness by optical coherence tomography (OCT) after intravitreal injections of bevacizumab for treatment neovascular age-related macular degeneration (AMD).A retrospective case series a university-based practice evaluated patients with subfoveal choroidal neovascularization (CNV) due to AMD. Patients received (1.25 mg) were monitored monthly determination best-corrected ETDRS OCT persistence thickening. Eyes retreated on an "as...
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs a number genes, other modes regulation are also likely to play role etiology this disease. We identified significantly decreased level methylation on IL17RC promoter patients. Furthermore, we showed that hypomethylation patients led an elevated expression its protein messenger RNA...
Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role AMD pathogenesis. Recent studies have demonstrated a strong genetic association between and complement factor H (CFH), down-regulatory activation. Elevated levels activating molecules including component 5a (C5a) found serum patients. Our aim study whether C5a can impact human T cells its...
Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related macular degeneration (AMD), one of the first batch most successful examples genome-wide association study. However, to date focused on case-control late AMD (choroidal neovascularization or geographic atrophy). The influences disease progression are largely unexplored. We assembled unique resources perform a bivariate time-to-event analysis test time-to-late-AMD with...
Objective: To evaluate associations between nuclear cataract (determined from slitlamp photographs May 2001 and January 2004) lutein zeaxanthin in the diet serum patients
Age-related macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision loss in elderly, is associated with polymorphisms LOC387715/ARMS2 HTRA1 genes on 10q26. Like humans, macaque monkeys possess macula develop age-related pathologies including drusen, phenotypic hallmark AMD. We genotyped cohort 137 unrelated rhesus macaques without drusen. As one variant within were significantly affected status. predicted gene both transcribed human retina retinal...
Abstract Ding et al. used data from large clinical trials to evaluate the effects of known age-related macular generation (AMD) risk variants on disease progression... Age-related degeneration is a leading cause blindness in developed world. While many AMD susceptibility have been identified, their influence progression has not elucidated. Using two trials, Age-Related Eye Disease Study (AREDS) and AREDS2, we evaluated 34 progression. In doing so, calculated eye-level time-to-late modeled...
Age-related macular degeneration (AMD) is a common threat to vision loss in individuals older than 50 years. While neovascular complications AMD are treatable, there currently no therapy for geographic atrophy secondary AMD. Geographic lesion progression over time shows considerable interindividual variability, but little known about prognostic factors.To elucidate the contribution of genetic variants growth.This pooled analysis combined 4 independent studies: Fundus Autofluorescence Imaging...
<h3>Objectives</h3> To correlate clinical and histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration investigate the expression von Willebrand factor (VWF) vascular endothelial growth (VEGF) in this condition. <h3>Methods</h3> Histopathologic from serial sections through globe 87-year-old woman RAP were studied compared fluorescein angiography color fundus photographs obtained 4 months before death. Commercially available...