A5036302697- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Optical Coherence Tomography Applications
- melanin and skin pigmentation
- Antioxidant Activity and Oxidative Stress
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Proteoglycans and glycosaminoglycans research
- Nutritional Studies and Diet
- Ocular Oncology and Treatments
- Topic Modeling
- Dye analysis and toxicity
- Cancer, Hypoxia, and Metabolism
- Corneal surgery and disorders
- Digital Imaging for Blood Diseases
- Artificial Intelligence in Healthcare
- Neurological Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Glycosylation and Glycoproteins Research
- Hallucinations in medical conditions
- Intraocular Surgery and Lenses
National Eye Institute
2017-2025
National Institutes of Health
2017-2025
National Center for Biotechnology Information
2023
Moorfields Eye Hospital NHS Foundation Trust
2022
University College London
2022
Tel Aviv Sourasky Medical Center
2021
Research Applications (United States)
2020
University of Manchester
2010-2018
Manchester Royal Eye Hospital
2010-2016
University of Utah
2015
After the Age-Related Eye Disease Study 2 (AREDS2) study, beta carotene component was replaced by lutein/zeaxanthin for development of revised AREDS supplement. However, it is unknown if increased risk lung cancer observed in those assigned persists beyond conclusion AREDS2 trial and there a benefit adding to original supplement that can be with long-term follow-up.To assess 10-year developing late age-related macular degeneration (AMD).This multicenter epidemiologic follow-up study clinical...
Purpose.: To map the distribution of different classes glycosaminoglycans (GAGs) in healthy human retina, choroid, and sclera. Methods.: Frozen tissue sections were made from adult donor eyes. The GAG chains proteoglycans (PGs) detected with antibodies directed against various structures (either directly or after pretreatment GAG-degrading enzymes); hyaluronan (HA) was using biotinylated recombinant G1-domain versican. primary detection reagents identified FITC-labeled probes analyzed by...
PurposeTo apply a deep learning algorithm for automated, objective, and comprehensive quantification of OCT scans to large real-world dataset eyes with neovascular age-related macular degeneration (AMD) make the raw segmentation output data openly available further research.DesignRetrospective analysis images from Moorfields Eye Hospital AMD Database.ParticipantsA total 2473 first-treated 493 second-treated that commenced therapy between June 2012 2017.MethodsA was used segment all baseline...
Purpose: To examine relationships between retinal structure and visual function in geographic atrophy (GA) by analyzing spatial agreement absolute scotomas macular structure, focusing on (1) choroidal hypertransmission, a key feature of complete pigment epithelium outer (cRORA), (2) fundus autofluorescence (FAF)–defined GA. Methods: Mesopic microperimetry (using novel T-shaped pattern) multimodal imaging were recorded longitudinally phase II GA trial. Horizontal vertical optical coherence...
The potential association between age-related macular degeneration (AMD) and Alzheimer disease (AD) is uncertain has implications for understanding pathogenesis, referral, treatments.To determine whether individuals admitted to the hospital with AMD were significantly more or less likely develop AD dementia in following years, as well assess people be treatment years diagnosis of dementia.An cohort 65,894 was constructed from English National Health Service, linked episode statistics January...
To examine the presence and distribution of proteoglycan (PG) core proteins in adult human retina, choroid, sclera.Postmortem eye tissue was dissected into Bruch's membrane/choroid complex, isolated membrane, or neurosensory retina. PGs were extracted partially purified by anion exchange chromatography. Trypsinized peptides analyzed tandem mass spectrometry PG identified database search. The examined immunofluorescence microscopy on macular sections.The basement membrane perlecan, agrin,...
By 2040, age-related macular degeneration (AMD) will affect ~288 million people worldwide. Identifying individuals at high risk of progression to late AMD, the sight-threatening stage, is critical for clinical actions, including medical interventions and timely monitoring. Although deep learning has shown promise in diagnosing/screening AMD using color fundus photographs, it remains difficult predict individuals' risks accurately. For both tasks, these initial attempts have remained largely...
To describe past trends and future projections for the number of intravitreal injections being administered at a large tertiary hospital in London, United Kingdom.Retrospective data from Moorfields Eye Hospital were collected using electronic medical record system. Descriptive statistics used to visualise overall trends. Time series forecasting was predict that will be up including year 2029.The has increased nearly 11-fold 2009 2019, with total 44,924 delivered 2019. The majority given...
To evaluate longitudinally the performance of Notal Vision Home OCT (NVHO), comprising a spectral-domain device for patient self-imaging at home, telemedicine infrastructure automated data upload, and deep learning algorithm evaluation. The aims were to study system's in daily image acquisition analysis characterize dynamics retinal fluid exudation neovascular age-related macular degeneration (nAMD).Pilot prospective, observational longitudinal study.Four individuals (mean age, 73.8 years)...
Introduction - Retinal layer segmentation in optical coherence tomography (OCT) images is an important approach for detecting and prognosing disease. Automating using robust machine learning techniques lead to computationally efficient solutions significantly reduces the cost of labor-intensive labeling, which traditionally performed by trained graders at a reading center, sometimes aided semi-automated algorithms. Although several algorithms have been proposed since revival deep learning,...
Age-related cataracts are the leading cause of visual impairment among older adults. Many significant cases remain undiagnosed or neglected in communities, due to limited availability accessibility cataract screening. In present study, we report development and validation a retinal photograph-based, deep-learning algorithm for automated detection visually cataracts, using more than 25,000 images from population-based studies. internal test set, area under receiver operating characteristic...