A5030267280- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Viral Infections and Vectors
- melanin and skin pigmentation
- Bartonella species infections research
- Systemic Lupus Erythematosus Research
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Sarcoidosis and Beryllium Toxicity Research
- Rabies epidemiology and control
- Nephrotoxicity and Medicinal Plants
- Moyamoya disease diagnosis and treatment
- Vector-borne infectious diseases
- Retinal and Macular Surgery
- Ocular Oncology and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dermatological and Skeletal Disorders
- Vascular Tumors and Angiosarcomas
- Drug-Induced Ocular Toxicity
- Retinal Development and Disorders
- Traumatic Ocular and Foreign Body Injuries
- Retinal Imaging and Analysis
- CNS Lymphoma Diagnosis and Treatment
National Eye Institute
2022-2025
National Institutes of Health
2022-2025
Washington University Medical Center
2021
George Washington University
2021
Purpose: To examine relationships between retinal structure and visual function in geographic atrophy (GA) by analyzing spatial agreement absolute scotomas macular structure, focusing on (1) choroidal hypertransmission, a key feature of complete pigment epithelium outer (cRORA), (2) fundus autofluorescence (FAF)–defined GA. Methods: Mesopic microperimetry (using novel T-shaped pattern) multimodal imaging were recorded longitudinally phase II GA trial. Horizontal vertical optical coherence...
Importance Existing therapies to slow geographic atrophy (GA) enlargement in age-related macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal administration, and increase the risk of neovascular AMD. Additional therapeutic approaches are desirable. Objective To evaluate safety possible efficacy oral minocycline, a microglial inhibitor, for treatment GA Design, Setting, Participants This was phase 2, prospective, single-arm, 45-month, nonrandomized...
Tumor necrosis factor inhibitors (TNFis) can induce antidrug antibody (ADA) formation and loss of therapeutic response. However, the utility ADA testing association between ADAs treatment response in patients with noninfectious uveitis (NIU) is not well understood.To assess frequency their drug levels clinical NIU treated adalimumab or infliximab.This retrospective cross-sectional study included diagnosed who received infliximab underwent for serum level at National Eye Institute from...
Purpose To describe a case of acute macular neuroretinopathy (AMN) in patient with recent COVID-19 vaccination and infection who demonstrated atypical features on presentation.Observations A 64-year-old woman presented central vision loss both eyes (OU). She had recently received the Moderna vaccine rapidly developed systemic symptoms. Testing revealed infection. Visual acuities were 20/200 OU near-infrared reflectance hypo-reflective lesions maculae OU, optical coherence tomography (OCT)...
Methods A retrospective review of records patients that received aflibercept for UME from January 2017 to August 2022 was conducted. The primary outcomes were mean change in visual acuity (VA) and central subfield thickness (CST) 6 12 months the start treatment.
ObjectiveTo characterize changes in the retinal microvasculature eyes with birdshot chorioretinopathy (BCR) using optical coherence tomography angiography (OCTA).DesignRetrospective, observational, single center.SubjectsTwenty-eight patients (53 eyes) BCR and 59 age-matched controls (110 eyes).MethodsEn-face OCTA images of superficial capillary plexus (SCP) deep (DCP) each eye were assessed for presence microvascular abnormalities used to measure vessel foveal avascular zone (FAZ) areas. A...
Purpose To report a case of bilateral exudative retinal detachments and panuveitis in patient with multiple myeloma (MM).Case Report A 54-year-old non-proliferative diabetic retinopathy was referred blurred vision scotomas both eyes (OU). Three months prior to the onset ocular symptoms, he diagnosed systemic MM receiving chemotherapy. Clinical examination revealed best-corrected visual acuities 20/80 OU, rare anterior chamber cell, 2+ vitreous diffuse intraretinal hemorrhages, (RD). Optical...
To report the use of combination intravitreal pharmacotherapy using anti-vascular endothelial growth factor (VEGF) and short long-term corticosteroid implants for treatment retinal vasoproliferative tumors (VPT) associated with intermediate uveitis.Retrospective chart review patients VPT secondary to idiopathic uveitis that underwent at a single center was performed. Multimodal imaging including ultrawide field color fundus photography, fluorescein angiography, optical coherence tomography...
Abstract Purpose: To report the clinical features and treatment course of a case central retinal vein occlusion (CRVO) as initial sign ocular Bartonella henselae ( B. ) infection. Observation: A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) 20/400 in left eye. Clinical examination revealed CRVO with atypical including significant peripapillary exudates peripheral vascular...
To report the clinical features and treatment course of a case central retinal vein occlusion (CRVO) as initial sign ocular Bartonella henselae (B. henselae) infection.A 36-year-old male was evaluated for unilateral vision loss. He denied prodromal symptoms but reported prior exposure to fleas. Best corrected visual acuity (BCVA) 20/400 in left eye. Clinical examination revealed CRVO with atypical including significant peripapillary exudates peripheral vascular sheathing. Laboratory testing...
The purpose of this study was to report an unusual case pseudoxanthoma elasticum presenting with inflammatory phenotype associated atypical and rapidly progressive subretinal fibrosis.
The aim of this study was to report novel indocyanine green angiography findings optic disk granulomas secondary sarcoidosis. This an observational case report. A 36-year-old White man, who had previously been evaluated for birdshot chorioretinopathy and tested HLA-A29 negative, referred evaluation choroidal lesions in both eyes. Fundus examination revealed ovoid bilaterally the posterior pole. Optical coherence tomography demonstrated bilateral focal elevations pole disks consistent with...