A5088588454- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Antioxidant Activity and Oxidative Stress
- melanin and skin pigmentation
- Nutritional Studies and Diet
- Connexins and lens biology
- Retinal Development and Disorders
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Ocular Oncology and Treatments
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Cancer, Hypoxia, and Metabolism
- Dye analysis and toxicity
- Systemic Lupus Erythematosus Research
- Hallucinations in medical conditions
- Ophthalmology and Visual Health Research
- Genetic Associations and Epidemiology
- interferon and immune responses
- Digital Imaging for Blood Diseases
- Advanced Glycation End Products research
National Institutes of Health
2016-2025
National Eye Institute
2016-2025
Research Applications (United States)
2010-2022
Emmes (United States)
2009-2020
W.K. Kellogg Foundation
2020
University of Michigan–Ann Arbor
2020
George Washington University
2009
<h3>Importance</h3> The Age-Related Eye Disease Study (AREDS) formulation for the treatment of age-related macular degeneration (AMD) contains vitamin C, E, beta carotene, and zinc with copper. 2 (AREDS2) assessed value substituting lutein/zeaxanthin in AREDS because demonstrated risk lung cancer from carotene smokers former lutein zeaxanthin are important components retina. <h3>Objective</h3> To further examine effect supplementation on progression to late AMD. <h3>Design, Setting,...
Providing long-term follow-up of the natural history age-related macular degeneration (AMD) and associated risk factors will facilitate future epidemiologic studies clinical trials.
After the Age-Related Eye Disease Study 2 (AREDS2) study, beta carotene component was replaced by lutein/zeaxanthin for development of revised AREDS supplement. However, it is unknown if increased risk lung cancer observed in those assigned persists beyond conclusion AREDS2 trial and there a benefit adding to original supplement that can be with long-term follow-up.To assess 10-year developing late age-related macular degeneration (AMD).This multicenter epidemiologic follow-up study clinical...
OBJECTIVE—Diabetes is a leading cause of morbidity and mortality. The purpose this study to assess the associations between diabetes complications mortality in Early Treatment Diabetic Retinopathy Study (ETDRS). RESEARCH DESIGN AND METHODS—We examined demographic, clinical, laboratory characteristics 3,711 subjects enrolled ETDRS, randomized controlled clinical trial designed evaluate role laser photocoagulation aspirin therapy for diabetic retinopathy. outcome assessed was all-cause...
<h3>Importance</h3> Observational data have suggested that high dietary intake of saturated fat and low vegetables may be associated with increased risk Alzheimer disease. <h3>Objective</h3> To test the effects oral supplementation nutrients on cognitive function. <h3>Design, Setting, Participants</h3> In a double-masked randomized clinical trial (the Age-Related Eye Disease Study 2 [AREDS2]), retinal specialists in 82 US academic community medical centers enrolled observed participants who...
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs a number genes, other modes regulation are also likely to play role etiology this disease. We identified significantly decreased level methylation on IL17RC promoter patients. Furthermore, we showed that hypomethylation patients led an elevated expression its protein messenger RNA...
Age related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role AMD pathogenesis. Recent studies have demonstrated a strong genetic association between and complement factor H (CFH), down-regulatory activation. Elevated levels activating molecules including component 5a (C5a) found serum patients. Our aim study whether C5a can impact human T cells its...
To characterize changes in macular sensitivity during geographic atrophy (GA) progression using microperimetry.Retinal the area was evaluated by microperimetry 10 patients with bilateral GA, adequate data obtained 9 of (n = 18 eyes). Patients had been enrolled an interventional trial which one eye randomized to treatment and other observed. No effect regard GA growth microperimetric measurements detected, all eyes were analyzed. Microperimetric assessments central 20° macula performed every...
Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people western European origin. While structural functional alterations mitochondria (mt) their metabolites have been implicated pathogenesis vascular diseases, relationship inherited variants mitochondrial genome mt haplogroup subtypes with advanced AMD has not reported large prospective cohorts.We examined mtDNA 1168 using three-stage design on...