A5103201137- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Agriculture and Farm Safety
- Intraocular Surgery and Lenses
- Traffic and Road Safety
- Cerebrovascular and genetic disorders
- Ocular Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medication Adherence and Compliance
- Ophthalmology and Visual Impairment Studies
- Blood Coagulation and Thrombosis Mechanisms
- Pharmaceutical Practices and Patient Outcomes
- Urban Transport and Accessibility
- Telemedicine and Telehealth Implementation
- Drug-Induced Ocular Toxicity
- Pharmaceutical studies and practices
- Agriculture Sustainability and Environmental Impact
- Protein Tyrosine Phosphatases
- Adipose Tissue and Metabolism
- Genetically Modified Organisms Research
Blacktown & Mount Druitt Hospital
2023-2024
Ramathibodi Hospital
2012
Mahidol University
2012
Oregon Health & Science University
2003-2012
Rockefeller University
2007-2011
Foundation Fighting Blindness
2011
Research to Prevent Blindness
2011
Legacy Health
2008
Tufts Medical Center
2007
Harvard University
2007
We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH ( P < 10 −75 ), ARMS2 −59 C2/CFB −20 C3 −9 CFI −6 ). compared our top findings with the Tufts/Massachusetts General Hospital study of advanced (821 cases, 1,709 controls) genotyped 30 promising markers additional individuals (up to 7,749 4,625 controls). With these data, we identified locus TIMP3 (overall = 1.1 × −11...
Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD).To assess whether these genetic variants prognostic importance for progression to advanced AMD related visual loss.Prospective analysis of 1466 white participants Age-Related Eye Disease Study (AREDS), a US multicenter clinical trial conducted from 1990 2001 mean follow-up time 6.3 years. Age-related status was determined by grading fundus...
Age-related macular degeneration is the most common cause of irreversible visual impairment in developed world. Advanced age-related consists geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to are largely unknown.We tested for an association between functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving substitution phenylalanine leucine at amino acid 412) Americans European descent. We also effect TLR3 Leu Phe on...
Age-related macular degeneration (AMD) is a common cause of severe vision loss. Identification the genes involved in AMD will lead to better understanding this disease at molecular level, which eventually early detection, prevention and treatment. Previously, we mapped ARMD1 gene 1q25-31 large family with AMD. Here, narrow locus 14.9 Mb between LAMB2 D1S3469, region containing 50 known genes. Twenty candidate within were screened for mutations. Only one DNA variation, an A16,263G transition...
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs a number genes, other modes regulation are also likely to play role etiology this disease. We identified significantly decreased level methylation on IL17RC promoter patients. Furthermore, we showed that hypomethylation patients led an elevated expression its protein messenger RNA...
Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved low-density cholesterol modulation. Potential interaction APOE sex, smoking status has been reported. We present pooled analysis (n = 21,160) demonstrating late APOε4 (odds ratio [OR] 0.72 per haplotype; confidence interval [CI]: 0.65-0.74; P...
<h3>Background:</h3> Age related macular degeneration (AMD) is a leading cause of blindness. AMD complex disorder caused by genetic and environmental factors in which single nucleotide polymorphisms (SNPs) the genes <i>CFH</i> <i>LOC387715/HTRA1/ARMS2</i> have prognostic importance for <i>progression</i> to advanced (with visual loss). may also pharmacogenetic role affecting treatment response widely used nutritional supplements. This paper examines other susceptibility determine if these...
Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people western European origin. While structural functional alterations mitochondria (mt) their metabolites have been implicated pathogenesis vascular diseases, relationship inherited variants mitochondrial genome mt haplogroup subtypes with advanced AMD has not reported large prospective cohorts.We examined mtDNA 1168 using three-stage design on...
Individuals with acute zonal occult outer retinopathy (AZOOR) present initially progressive scotomata and photopsia. Characteristically, the extent of visual field defect is unexplained by fundal examination, but there marked retinal dysfunction evident electrophysiologically. It authors' experience that a group patients exhibit characteristic clinical electrophysiological abnormalities, which serve as criteria for working diagnosis.A retrospective observational case series 28 were...
<i>Background and Aims:</i> Age-related macular degeneration (AMD) is the leading cause of blindness in Western World. It now evident that both genetic environmental factors contribute to disease susceptibility. We tested hypotheses (a) a common coding SNP <i>LOC387715 </i>gene associated with advanced AMD (geographic atrophy or choroidal neovascularization), (b) modifiable exposures alter susceptibility this SNP. <i>Methods:</i> A case-control association...
To design a risk assessment model for development of advanced age-related macular degeneration (AMD) incorporating phenotypic, demographic, environmental, and genetic factors.We evaluated longitudinal data from 2846 participants in the Age-Related Eye Disease Study. At baseline, these individuals had all levels AMD, ranging none to unilateral AMD (neovascular or geographic atrophy). Follow-up averaged 9.3 years. We performed Cox proportional hazards analysis with covariates constructed AMD....
To analyze static visual field sensitivity with topographic models of the hill vision (HOV), and to characterize several function indices derived from HOV volume.A software application, Visual Field Modeling Analysis (VFMA), was developed for perimetry data visualization analysis. Three-dimensional were generated 16 healthy subjects 82 retinitis pigmentosa patients. Volumetric indices, which are measures quantity comparable regardless perimeter test pattern, investigated. Cross-validation,...
Age-related macular degeneration (AMD), the leading cause of blindness in Western world, is a complex disease that affects people over 50 years old. The complement factor H (CFH) gene has been repeatedly shown to be major determining susceptibility advanced form condition. We aimed better understand functional role this AMD process and assess whether it associated with earlier forms disease.WE genotyped SNPS at cfh locus three independent populations AMD: (a) extended families where least 3...
To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over alone.This was a single-site, multiinvestigator, prospective, open-label, interventional, Phase II study of patients with new or recurrent exudative/neovascular age-related macular degeneration. Thirty eyes were enrolled consecutively randomized in ratio 2:1 to combination therapy topical bromfenac, alone. All received monthly for 4 months then as needed accordance standard care....
To investigate further the genetic contribution to age-related macular degeneration (AMD), increasing power of a previous analysis and reproducing original findings.A large cohort families with this condition was assembled, an expanded genome scan performed 556 microsatellite markers. In 2003, results were reported genome-wide linkage 70 these pedigrees. Members 51 new have now been ascertained many pedigrees expanded. Parametric nonparametric analyses denser map addition, sample stratified...