A5103169354- Retinal Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Glaucoma and retinal disorders
- Ultrasound Imaging and Elastography
- Hepatocellular Carcinoma Treatment and Prognosis
- Retinal Imaging and Analysis
- Photoacoustic and Ultrasonic Imaging
- Trauma Management and Diagnosis
- Spinal Cord Injury Research
- MRI in cancer diagnosis
- Chronic Kidney Disease and Diabetes
- Atherosclerosis and Cardiovascular Diseases
- Retinal Development and Disorders
- Corneal Surgery and Treatments
- Cerebrovascular and genetic disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cervical and Thoracic Myelopathy
- Cancer, Hypoxia, and Metabolism
- Erythropoietin and Anemia Treatment
- Lattice Boltzmann Simulation Studies
- Ultrasound in Clinical Applications
- Automotive and Human Injury Biomechanics
- Physical Activity and Health
- Pain Management and Placebo Effect
- Spinal Dysraphism and Malformations
University of Washington
2022-2024
Neurological Surgery
2022-2024
Tulane University
2018-2020
Michigan Medicine
2018
University of Michigan
2016
SUNY Brockport
2014
University of Utah
2006-2010
Eye Institute of Utah
2009-2010
Institute of Human Genetics
2008
Doheny Eye Institute
2006
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affects risk AMD, but precise gene(s) have not been identified. We genotyped 581 AMD cases 309 normal controls Caucasian cohort Utah. demonstrate that single-nucleotide polymorphism, rs11200638, promoter region HTRA1 likely causal variant for estimated to confer population attributable 49.3%. The gene encodes...
Age-related macular degeneration is the most common cause of irreversible visual impairment in developed world. Advanced age-related consists geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to are largely unknown.We tested for an association between functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving substitution phenylalanine leucine at amino acid 412) Americans European descent. We also effect TLR3 Leu Phe on...
Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. Proliferative diabetic retinopathy (PDR) end stage renal disease (ESRD) are two the most common severe complications diabetes. A high concordance exists in development PDR ESRD patients, as well strong familial aggregation these complications, suggesting underlying genetic mechanism. However, precise gene(s) variant(s) involved remain...
Abstract Background Focal and segmental glomerulosclerosis (FSGS) is the most common histologic pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound heterozygous mutations podocin gene NPHS2 are found 10–30% pediatric cases steroid resistant nephrosis and/or FSGS. Methods We studied spectrum genetic variation 371 individuals predominantly late onset FSGS (mean age 25 years) by analysis DNA samples. Results identified 15 non-synonymous alleles that...
Spinal cord injury is characterized by hemodynamic disruption at the epicenter and hypoperfusion in penumbra, resulting progressive ischemia cell death. This degenerative secondary process has been well-described, though mostly using ex vivo or depth-limited optical imaging techniques. Intravital contrast-enhanced ultrasound enables longitudinal, quantitative evaluation of anatomical changes through entire spinal parenchyma. Here, we used to visualize quantify subacute expansion (through 72...
Abstract Ultrasound localization microscopy (ULM) is a recent advancement in ultrasound imaging that uses microbubble contrast agents to yield vascular images break the classical diffraction limit on spatial resolution. Current approaches cannot image blood flow at tissue perfusion level since they rely solely differences velocity separate and signals; lower echoes are removed during high pass wall filtering. To visualize entire tree, we have developed nonlinear ULM, which combines pulsing...
Normal aging is associated with significant deleterious cerebrovascular changes; these have been implicated in disease pathogenesis and increased susceptibility to ischemic injury. While changes are well documented the brain, few studies conducted spinal cord. Here, we utilize specialized contrast-enhanced ultrasound (CEUS) imaging investigate age-related cervical vascular anatomy hemodynamics male Fisher 344 rats, a common strain research. Aged rats (24-26 mo., N=6) exhibited tortuosity...
Abstract Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. Many patients are not eligible for curative therapies, such as surgical resection tumor or a liver transplant. Transarterial embolization one therapy clinically used in these cases; however, this requires long procedure and careful placement an intraarterial catheter. Gas has been proposed fast, easily administered, more spatially selective, less invasive alternative. Here, we demonstrate...
Traumatic spinal cord injury (tSCI) causes an immediate loss of neurological function, and the prediction recovery is difficult in acute phase. In this study, we used contrast-enhanced ultrasound imaging to quantify intraspinal vascular disruption acutely after tSCI. a rodent thoracic tSCI model, revealed perfusion area deficit that was positively correlated with severity negatively hindlimb locomotor function at 8 weeks injury. The index calculated by normalizing contrast inflow center...
Purpose Understanding the physical activity patterns of youth is an essential step in addressing obesity epidemic and, ultimately, developing programs that reverse this trend. Therefore, purpose study was to explore habitual Hispanic and African-American children living a northeastern USA urban environment. Methods Participants included 39 inner-city (10.5 ± 0.61 years old; 78% African American, 14% Hispanic; 85% free/reduced lunch; 20.3 4.3 BMI with 45% overweight/obese). Children wore...
infarction shows promise as a treatment. Gas embolotherapy tries to achieve this by locally occluding blood vessels supplying using bubbles resulting from of liquid Sufficient occlusion may be necessary in order starve death. The purpose study is increase vivo changing the pulse repetition frequency (PRF) improve therapy. One milliliter solution containing 3 x 107 lipid-coated perfluorocarbon was injected through tail vein rat at rate 0.1 mL/min. Acoustic (ADV) induced feeder vessel exposed...
Trans-arterial embolization is a commonly used therapy in unresectable hepatocellular carcinoma. Current methods involve the careful placement of an intraarterial catheter and deposition embolizing particles. Gas embolotherapy has been proposed as method with potential for high spatial resolution without need catheter. This involves vaporizing intravenouslyadministered droplets into gas bubbles using focused ultrasound - process termed acoustic droplet vaporization. The can become lodged...
Targeted therapy and molecular imaging using ultrasound have been widely explored microbubble contrast agents, more recently, activatable droplet agents that vaporize when exposed to focused explored. These droplets are coated with a stabilizing, functionalizable shell, typically comprised of fully saturated phospholipids. While the shedding lipid shell under exposure is well-studied phenomenon in microbubbles, it has not droplet-based particularly those undergo reversible phase change...
Normal aging is associated with significant deleterious cerebrovascular changes; these have been implicated in disease pathogenesis and increased susceptibility to ischemic injury. Although changes are well documented the brain, few studies conducted spinal cord. Here, we utilize specialized contrast-enhanced ultrasound (CEUS) imaging investigate age-related cervical vascular anatomy hemodynamics male Fisher 344 rats, a common strain research. Aged rats (24-26 months, N = 6) exhibited...
Abstract Traumatic spinal cord injury (tSCI) leads to an immediate loss of neurological function, with its recovery being difficult predict in the acute phase. Here, we developed a contrast-enhanced ultrasound (CEUS) imaging biomarker quantify intraspinal vascular disruption after tSCI. In rodent thoracic tSCI, CEUS revealed perfusion area deficit (PAD) which increased severity (p = 0.001). The PAD size significantly correlated hindlimb locomotor function at 8 weeks post (R 2 0.82, p <...