A5080292624- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Visual perception and processing mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Connexins and lens biology
- Photoreceptor and optogenetics research
- Retinopathy of Prematurity Studies
- Corneal surgery and disorders
- Drug-Induced Ocular Toxicity
- Pregnancy and preeclampsia studies
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Ocular and Laser Science Research
- Circadian rhythm and melatonin
- Neurological Disease Mechanisms and Treatments
- Spaceflight effects on biology
- Parkinson's Disease Mechanisms and Treatments
- Hallucinations in medical conditions
- melanin and skin pigmentation
- EEG and Brain-Computer Interfaces
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Greater Baltimore Medical Center
2016-2025
University of Maryland, Baltimore
2015-2024
Technion – Israel Institute of Technology
2016
Johns Hopkins University
2000-2012
Johns Hopkins Medicine
1995-2012
Network Group (Czechia)
2012
Research Network (United States)
2012
Winter Haven Hospital
2012
Massachusetts Eye and Ear Infirmary
2012
Harvard University
2012
ObjectiveTo describe the progression of geographic atrophy (GA) from age-related macular degeneration (AMD) with respect to visual acuity (VA) loss and enlargement atrophy.DesignA prospectively observed case series.SettingTertiary retinal referral center.ParticipantsOne hundred twenty-three patients GA due AMD who completed at least 1 year follow-up (median follow-up, 3 years) were examined annually.MethodsAt each examination, a protocol best-corrected VA eye was measured, clinical...
Age-related macular degeneration is the most common cause of irreversible visual impairment in developed world. Advanced age-related consists geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to are largely unknown.We tested for an association between functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving substitution phenylalanine leucine at amino acid 412) Americans European descent. We also effect TLR3 Leu Phe on...
Nanophthalmos is a rare disorder of eye development characterized by extreme hyperopia (farsightedness), with refractive error in the range +8.00 to +25.00 diopters. Because cornea and lens are normal size shape, occurs because insufficient growth along visual axis places these lensing components too close retina. Nanophthalmic eyes show considerable thickening both choroidal vascular bed scleral coat, which provide nutritive structural support for Thickening tissues general feature axial...
Objective: To characterize the traits of low vision patients who seek outpatient rehabilitation (LVR) services in United States.Methods: In a prospective observational study, we enrolled 764 new seeking LVR from 28 clinical centers States.Before their initial appointment, multiple questionnaires assessing daily living and vision, physical, psychological, cognitive health states were administered by telephone.Baseline visual impairment measures disorder diagnoses recorded.Results: Patients...
<h3>Background/aims</h3> Inflammation has been implicated in age-related macular degeneration (AMD). This study investigates the association of mast cells (MCs), a resident choroidal inflammatory cell, with pathological changes AMD. <h3>Methods</h3> Human donor eyes included aged controls (n=10), clinically diagnosed early AMD (n=8), geographic atrophy (GA, n=4) and exudative (n=11). The choroids were excised incubated for alkaline phosphatase (APase; blood vessels) non-specific esterase...
Sensitive outcome measures for disease progression are needed treatment trials of Stargardt disease.To estimate the rate atrophic lesions in prospective Natural History Progression Atrophy Secondary to Disease (ProgStar) study over a 12-month period.This multicenter cohort was conducted an international selection tertiary referral centers from October 21, 2013, February 15, 2017. Patients who were affected by disease, aged 6 years and older at baseline, harboring disease-causing variants...
New outcome measures for treatment trials Stargardt disease type 1 (STGD1) and other macular diseases are needed. Microperimetry allows mapping of light sensitivity the macula provides topographic information on visual function beyond acuity.To measure analyze retinal in STGD1 using fundus-controlled perimetry (microperimetry).This was a multicenter prospective cohort study. A total 199 patients 326 eyes with molecularly confirmed (ABCA4) underwent testing Nidek MP-1 microperimeter as part...
Fourteen cases of central serous chorioretinopathy in pregnancy had been reported before this study was conducted. These have suggested a nonwhite predominance. Subretinal fibrinous exudates seen 90% the patients, compared with fewer than 20% patients typical (nonpregnant) chorioretinopathy. No case has recurred outside pregnancy, to our knowledge, and there no reports subsequent pregnancies uninvolved by disorder. findings led us collect retinopathy because experience differed from that...
Foveal-sparing scotomas are common in advanced dry macular degeneration (geographic atrophy). Foveal preservation may be present for a number of years. Despite good visual acuity, these patients have reduced reading rates. Magnification not effective if the text becomes too large to “fit” within central spared area.
In Brief Purpose: To describe, in a group of patients with moderately advanced retinitis pigmentosa (RP), the prevalence cystoid macular edema (CME), variation foveal thickness over 48-week period, correlation visual acuity (VA) retinal thickness, and lack response CME to lutein administration. Methods: Optical coherence tomography (OCT) imaging macula clinical examination were evaluated for 77 eyes 39 RP 11 months, scan done every 6 weeks. Results: The CME, defined by cysts visible on OCT,...
Aging changes are seen histopathologically outside the central retina, but have not been correlated with presence of age-related macular degeneration (AMD). We studied 21 patients drusen and AMD to see if peripheral retinal function in retina. Electrooculogram Arden ratios were normal. Intensity-response analysis dark-adapted electroretinogram b-waves flicker electroretinograms normal except for a small sensitivity loss presumed reflect aging lens yellowing. There was no difference between...