A5058727483- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Angiogenesis and VEGF in Cancer
- Photodynamic Therapy Research Studies
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Impairment Studies
- Ocular Oncology and Treatments
- Cell death mechanisms and regulation
- Systemic Lupus Erythematosus Research
- Retinoids in leukemia and cellular processes
- Connexins and lens biology
- Metabolomics and Mass Spectrometry Studies
- Ophthalmology and Eye Disorders
- Ocular Infections and Treatments
- Ophthalmology and Visual Health Research
- Optical Coherence Tomography Applications
Harvard University
2016-2025
Massachusetts Eye and Ear Infirmary
2016-2025
Retina Associates
2017-2024
Incorporated Research Institutions For Seismology
2021-2023
Mass General Brigham
2022
Massachusetts General Hospital
2010-2022
Brigham and Women's Hospital
2014-2022
University of North Carolina at Chapel Hill
2022
The Retina Center
2019-2021
Indiana University Health
2019
We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH ( P < 10 −75 ), ARMS2 −59 C2/CFB −20 C3 −9 CFI −6 ). compared our top findings with the Tufts/Massachusetts General Hospital study of advanced (821 cases, 1,709 controls) genotyped 30 promising markers additional individuals (up to 7,749 4,625 controls). With these data, we identified locus TIMP3 (overall = 1.1 × −11...
Glaucoma is a widespread ocular disease characterized by progressive loss of retinal ganglion cells (RGCs). Previous studies suggest that the cytokine tumor necrosis factor-α (TNF-α) may contribute to process, although its role in vivo and mechanism action are unclear. To investigate pathophysiological mechanisms glaucoma, we induced hypertension (OH) mice angle closure via laser irradiation. This treatment resulted rapid upregulation TNF-α, followed sequentially microglial activation, optic...
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological neovascularization. In the current paper, mechanisms of neovascularization are compared contrasted. During neovascularization, absolute relative expression levels for VEGF164 increased to a greater degree than during Furthermore, extensive leukocyte adhesion was observed at leading edge pathological, but not physiological, When VEGF164-specific neutralizing aptamer administered, it potently...
Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment photoreceptors from the retinal pigment epithelium, as seen various disorders, causes photoreceptor and subsequent vision decline. Although caspase-dependent apoptotic pathways are activated after detachment, caspase inhibition by pan-caspase inhibitor Z-VAD fails prevent death; thus, we investigated other leading loss. Here, show that receptor interacting protein (RIP) kinase-mediated necrosis is...
To determine whether the angiogenic peptide vascular endothelial growth factor (VEGF) is sufficient to produce iris neovascularization in a nonhuman primate (Macaca fascicularis).Eight eyes of 4 animals were studied. The 165-amino acid isoform human recombinant VEGF (VEGF165) was injected into vitreous 5 cynomolgus monkey (doses ranging from 0.25-2.5 micrograms per injection). Equal amounts inactivated (2 eyes) or vehicle (1 eye) contralateral control eyes. Eyes assessed by slitlamp...
Miller, J W; Adamis, A P; Shima, D T; D'Amore, P A; Moulton, R S; O'Reilly, M Folkman, J; Dvorak, H F; Brown, L Berse, B
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and several other disorders, but the underlying mechanisms remain elusive. Recently, increased expression monocyte chemoattractant protein 1 (MCP-1) was reported vitreous humor samples patients with RD diabetic retinopathy as well brain tissues neurodegenerative diseases, including Alzheimer's disease multiple sclerosis. Here we report that MCP-1 plays critical role mediating photoreceptor an experimental...
To investigate photodynamic therapy of experimental choroidal neovascularization using benzoporphyrin derivative monoacid (Verteporfin).Photodynamic was investigated in cynomolgus monkeys. Following intravenous injection (1 to 2 mg/kg) complexed with low-density lipoprotein, the eyes were irradiated 692-nm light at a fluence 50 150 J/cm2 and irradiance 600 mW/cm2. Choroidal documented before closure demonstrated by fundus photography, fluorescein angiography, electron microscopic...