A5039687656- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Spondyloarthritis Studies and Treatments
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Peripheral Neuropathies and Disorders
- Skin Diseases and Diabetes
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2016-2025
Yunnan Academy of Agricultural Sciences
2025
Tea Research Institute
2025
Dalian Medical University
2023-2024
East China University of Science and Technology
2022-2024
Hefei Normal University
2023
Fudan University Shanghai Cancer Center
2019-2023
Fudan University
2012-2023
Shanghai Medical College of Fudan University
2019-2023
Neutrophil extracellular traps (NETs) have been shown to play an important role in systemic lupus erythematosus (SLE) pathogenesis by activating plasmacytoid dendritic cells (PDCs) and the type I interferon (IFN) pathway. NETs composed of self-DNA are considered be nuclear origin a major source anti-DNA autoantibody generation. This study was undertaken evaluate whether mitochondrial DNA (mtDNA) resides NETs, mtDNA anti-mtDNA antibodies cause dysregulation PDC-IFNα pathway, investigate...
Objective Changes in gut microbiota have been linked to systemic lupus erythematosus (SLE), but knowledge is limited. Our study aimed provide an in‐depth understanding of the contribution immunopathogenesis SLE. Methods Fecal metagenomes from 117 patients with untreated SLE and 52 posttreatment were aligned 115 matched healthy controls analyzed by whole‐genome profiling. For comparison, we assessed fecal metagenome MRL/ lpr mice. The oral origin species that existed was documented...
Abstract Objective To explore whether there are extrinsic factors that impair the suppressive function of CD4+,CD25+ regulatory T cells in patients with untreated active systemic lupus erythematosus (SLE). Methods We studied 15 SLE, 10 SLE remission, and healthy control subjects. Percentages CD4+,CD25+,FoxP3+ Treg levels forkhead box P3 (FoxP3) protein were analyzed by flow cytometry. Expression messenger RNA (mRNA) for FoxP3 purified cell populations was assessed real‐time polymerase chain...
Objectives To identify the predictive clinical characteristics and establish a prediction model for progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). Methods Patients SSc from two independent prospective cohorts were included this observational study. All fulfilled 2013 American College Rheumatology/European League Against Rheumatism criteria, had ILD at baseline diagnosed by High-Resolution Computed Tomography (HRCT), available ≥1 annual...
Abstract To evaluate the efficacy of pirfenidone in patients with rapidly progressive interstitial lung disease (RPILD) related to clinically amyopathic dermatomyositis (CADM), we conducted an open-label, prospective study matched retrospective controls. Thirty diagnosed CADM-RPILD a duration <6 months at Renji Hospital South Campus from June 2014 November 2015 were prospectively enrolled and treated target dose 1800 mg/d addition conventional treatment, such as glucocorticoid and/or...
The aim of this study was to develop and internally validate a medication nonadherence risk nomogram in Chinese population patients with inflammatory rheumatic diseases.We developed prediction model based on training dataset 244 IRD patients, data were collected from March 2016 May 2016. Adherence evaluated using 19-item Compliance Questionnaire Rheumatology. least absolute shrinkage selection operator regression used optimize feature for the model. Multivariable logistic analysis applied...
Abstract Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology pathogenesis of MDA5 DM are still largely unknown. Here we describe the immune signatures via single-cell RNA sequencing, flow cytometry multiplex immunohistochemistry in peripheral B T cells affected tissue samples from one patient. We find strong antibody-secreting cell CD8...
Rutin is a biologically active polyphenol, but its poor water solubility and low bioavailability limit application to the food industry. We investigated effect of ultrasound treatment on properties rutin (R) whey protein isolate (WPI) using spectral physicochemical analysis. The results revealed that there was covalent interaction between with rutin, binding degree increased treatment. Additionally, surface hydrophobicity WPI-R complex improved ultrasonic treatment, maximum 81.9 % at 300 W...
Objective To compare the effectiveness and safety of tofacitinib (TOF) versus calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5+DM-ILD). Methods Adult Chinese patients newly-diagnosed MDA5+DM-ILD (ILD course<3 months) from five tertiary referral centres between April 2014 January 2023 were included this retrospective cohort study. The primary endpoint was...
This study aimed to identify the long-term clinical outcomes and prognostic factors of patients with systemic lupus erythematosus (SLE)-associated pulmonary arterial hypertension (PAH) confirmed by right heart catheterisation.A multicentre prospective cohort SLE-associated PAH was established. Baseline follow-up records were collected. The primary end-point death. secondary exploratory treatment goal achievement (TGA), defined as an integrated outcome.In total, 310 enrolled from 14 centres....
Abstract Objectives Anti-melanoma differentiation-associated gene 5 (MDA5) positive DM is a life-threatening disease often complicated with rapidly progressive interstitial lung (ILD). This study aimed to establish and validate clinical prediction model for 6-month all-cause mortality in Chinese patients anti-MDA5 DM-ILD. Methods We conducted retrospective observational using single-centre derivation cohort multicentre validation cohort. Hospitalized antibody ILD course ≤3 months on...
Objective Sodium-glucose cotransporter-2 inhibitors have been identified profound renal/cardiac protective effects in different diseases. Here, we assessed the safety and efficacy of dapagliflozin among adult patients with systemic lupus erythematosus (SLE). Methods We conducted a single-arm, open-label, investigator-initiated phase I/II trial Chinese SLE with/without nephritis (LN). Patients received oral at daily dose 10 mg added to standard care for 6 months. The primary end point was...
Figure 1 Enrolment and primary outcome (N=14) (A), summary of adverse events (B) changes inflammatory cytokines in the 24week study (N=9) (C).GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; LEF, leflunomide; MTX, methotrexate; TNF, tumour necrosis VEGF, vascular endothelial growth factor.
Objective Gastrointestinal (GI) involvements were scarcely reported in adult anti-nuclear matrix protein 2 (NXP2) dermatomyositis (NXP2 + DM). In this study, we investigated the clinical, pathological and molecular features as well treatment options of rare yet life-threatening disease. Methods We retrospectively collected data cohort NXP2 DM from 2012 to 2022 our hospital. RNA sequencing was performed intestinal samples perforated patients compared with healthy controls set. Results A total...
Abstract Cytokine storm (CS) is linked with macrophage dysfunction and acute lung injury (ALI), which can lead to patient mortality. Glycolysis preferentially exploited by the pro-inflammatory macrophages, in pyruvate kinase M2 (PKM2) a critical enzyme. The mechanism underlying link between CS ALI involves cell death, recently discovered programmed death known as ferroptosis being involved. However, relationship glycolysis context of CS-related remains unclear. CS-associated induced poly I:C...
There is an unmet need for the development of new biomarkers idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD).Peripheral CD4+CXCR4+ T cells, stromal cell-derived factor-1 and Krebs von den Lungen-6 were measured in patients with IIM-ILD (n = 85) controls. The relation to pulmonary functions, high-resolution CT scores, specific clinical phenotypes survival was analysed. Cytokine-expression profiling these cells their co-culture fibroblasts conducted.The...