A5064836722- Systemic Lupus Erythematosus Research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis Viruses Studies and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Complement system in diseases
- Health and Medical Research Impacts
- Vasculitis and related conditions
- Lipoproteins and Cardiovascular Health
- Acne and Rosacea Treatments and Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmaceutical Practices and Patient Outcomes
- Diabetes and associated disorders
- Urological Disorders and Treatments
- Cancer-related gene regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
Shanghai Jiao Tong University
2016-2024
Fudan University
2024
Renji Hospital
2017-2024
Shaoxing People's Hospital
2024
First Hospital of Jilin University
2020-2023
Jilin University
2020-2023
Eli Lilly (United States)
2022-2023
Beijing Ditan Hospital
2020-2023
Capital Medical University
2011-2023
First Bethune Hospital of Jilin University
2019-2023
Abstract To evaluate the efficacy of pirfenidone in patients with rapidly progressive interstitial lung disease (RPILD) related to clinically amyopathic dermatomyositis (CADM), we conducted an open-label, prospective study matched retrospective controls. Thirty diagnosed CADM-RPILD a duration <6 months at Renji Hospital South Campus from June 2014 November 2015 were prospectively enrolled and treated target dose 1800 mg/d addition conventional treatment, such as glucocorticoid and/or...
Objective Sodium-glucose cotransporter-2 inhibitors have been identified profound renal/cardiac protective effects in different diseases. Here, we assessed the safety and efficacy of dapagliflozin among adult patients with systemic lupus erythematosus (SLE). Methods We conducted a single-arm, open-label, investigator-initiated phase I/II trial Chinese SLE with/without nephritis (LN). Patients received oral at daily dose 10 mg added to standard care for 6 months. The primary end point was...
There is an unmet need for the development of new biomarkers idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD).Peripheral CD4+CXCR4+ T cells, stromal cell-derived factor-1 and Krebs von den Lungen-6 were measured in patients with IIM-ILD (n = 85) controls. The relation to pulmonary functions, high-resolution CT scores, specific clinical phenotypes survival was analysed. Cytokine-expression profiling these cells their co-culture fibroblasts conducted.The...
To confirm that metformin prevents flares in patients with SLE low disease activity, we performed a post hoc analysis combining our previous two randomised trials.
Hepatitis B surface antigen (HBsAg) clearance is considered as functional cure in patients with chronic hepatitis (CHB). This study aimed to assess the durability of HBsAg achieved by interferon-based therapies CHB who were originally positive for envelope (HBeAg). In this prospective study, HBeAg-positive confirmed loss under enrolled within 12 weeks from end treatment and followed up 48 weeks. Virological markers, biochemical indicators, liver imaging examinations observed every 3-6...
Objective: The effectiveness and safety of belimumab in Chinese lupus patients with different disease activities were investigated a real-world setting. Method: Patients who received 10 mg/kg intravenously on weeks 0, 2, 4, then every 4 background standard-of-care (SoC) therapy had follow-up more than 6 months enrolled from four centers China. They stratified according to the Safety Estrogens Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) score at baseline...
Heart failure is a common adverse postoperative complication in elderly patients. It necessary to explore the risk factors of heart after operation patients with hip fracture during hospitalization.Patients fractures admitted our hospital from January 1, 2019 December 31 2020 were included, all received internal fixation surgery. The characteristics and without compared. Multivariate logistic regression analyses applied analyze fracture.A total 283 incidence was 12.37 %. There significant...
Activation of macrophages and overexpression TNFα is associated with the pathogenesis chronic inflammatory diseases. However, mechanisms leading to are still unknown. 5-methylocytosine (5-mC) an epigenetic modification that silenced genes. Recent studies showed it converted 5-hydroxylmethylocytosine (5-hmC) reactivates gene expression through action family Ten-Eleven-Translocation (TET1-3) enzymes. In this study, we show 5-hmC levels increased globally specifically in promoter during...
Ramucirumab is indicated for patients with advanced hepatocellular carcinoma (HCC) and α-fetoprotein (AFP) ≥400 ng/mL following sorafenib. Here, we prospectively studied ramucirumab non-sorafenib systemic therapies.This open-label, non-comparative cohort of REACH-2 enrolled HCC, Child-Pugh class-A liver disease, AFP who had received 1-2 lines therapy, excluding sorafenib or chemotherapy. was administered 8 mg/kg intravenously Q2W. The primary endpoint safety. Secondary endpoints were overall...
Patterns of pharmacologic treatment in U.S. outpatients with schizophrenia across multiple health care settings were investigated.
Objective To explore dynamic changes of cytokines and virological markers associated with hepatitis B surface antigen (HBsAg) loss during peginterferon alpha-2a (PEG-IFN α-2a) treatment in e (HBeAg) positive chronic (CHB) patients. Methods It was a single-center prospective cohort study. HBeAg-positive CHB patients were prospectively consecutively enrolled. Cytokines detected at baseline, week 12 24 PEG-IFN treatment. HBsAg disappearance rate the primary evaluation index 48 weeks Results...
To evaluate the risk of major infections and relationship between mortality in patients with newly diagnosed SLE.A (<3 months) hospitalised Systemic Lupus Inception Cohort (hSLIC) our centre during 1 January 2013 November 2020 was established. All were followed up for at least year or until death. Patient baseline characteristics collected. Major infection events recorded follow-up, which defined as microbiological/clinical-based diagnosis treated intravenous antimicrobials. The cohort...
Despite the high prevalence of posttraumatic stress disorder (PTSD) and medical comorbidity among veterans from Iraq/Afghanistan (OEF/OIF), keeping these patients engaged in health care is challenging. Primary Care-Mental Health Integration (PC-MHI), an initiative Veterans Administration (VA), sought to improve access mental within primary care. This study examined lag between first PC-MHI visit next mental/medical visit, if any, relationship with short-term (subsequent year) long-term (4...
Abstract To investigate the characteristics of cytokines in patients with different HBV infection status and their correlation DNA, HBsAg, HBeAg levels. Peripheral blood samples were collected from chronic immune tolerance phase (IT), HBeAg‐positive hepatitis B (CHB), acute (AHB) groups, levels detected by Luminex technique, analyzed FLEXMAP 3D analyzer. The between DNA load, HBeAg, alanine aminotransferase (ALT) level was analyzed. In total 312 subjects (184 males 128 females) enrolled...