A5101893855- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Nicotinic Acetylcholine Receptors Study
- 14-3-3 protein interactions
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Gout, Hyperuricemia, Uric Acid
- Ophthalmology and Visual Impairment Studies
- Acute Myeloid Leukemia Research
- Pancreatitis Pathology and Treatment
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Liver Diseases and Immunity
- Intraocular Surgery and Lenses
- Tryptophan and brain disorders
- Corneal surgery and disorders
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Lymphoma Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
China-Japan Friendship Hospital
2024-2025
Beijing Ditan Hospital
2015-2024
Capital Medical University
2015-2024
Peking Union Medical College Hospital
2017-2024
Anhui Medical University
2024
Chinese PLA General Hospital
2023
People's Liberation Army No. 150 Hospital
2022
Capital University
2019-2020
Guizhou University
2018
MicroRNAs (miRNAs) play important roles in the posttranscriptional regulation of gene expression. Recent evidence has indicated pathological relevance miRNA dysregulation hepatitis virus infection; however, microRNAs B (HBV) expression are still largely unknown. In this study we identified that miR-373 was up-regulated HBV-infected liver tissues and members miRs-371-372-373 (miRs-371-3) cluster were also significantly co-up-regulated HBV-producing HepG2.2.15 cells. A positive vivo...
The domestic water buffalo is native to the Asian continent but through historical migrations and recent importations, nowadays has a worldwide distribution. two types of buffalo, i.e. river swamp, display distinct morphological behavioural traits, different karyotypes also have purposes geographical distributions. River buffaloes from Pakistan, Iran, Turkey, Egypt, Romania, Bulgaria, Italy, Mozambique, Brazil Colombia, swamp China, Thailand, Philippines, Indonesia were genotyped with...
Abstract Hepatitis B surface antigen ( HB sAg) loss is considered a functional cure in chronic hepatitis CHB ). However, the durability of sAg after stopping treatment remains unknown. This study aimed to assess sustained achieved by interferon therapy envelope eAg)‐negative patients. In this prospective study, 176 eAg‐negative patients with were enrolled for 12 weeks cessation treatment, and information baseline data collected. virus HBV ) biomarkers clinical biochemical indicators...
Objective To explore dynamic changes of cytokines and virological markers associated with hepatitis B surface antigen (HBsAg) loss during peginterferon alpha-2a (PEG-IFN α-2a) treatment in e (HBeAg) positive chronic (CHB) patients. Methods It was a single-center prospective cohort study. HBeAg-positive CHB patients were prospectively consecutively enrolled. Cytokines detected at baseline, week 12 24 PEG-IFN treatment. HBsAg disappearance rate the primary evaluation index 48 weeks Results...
Background: Hepatitis B surface antigen (HBsAg) loss/seroconversion is considered to be the ideal endpoint of antiviral therapy and ultimate treatment goal in chronic hepatitis (CHB). This study aimed assess patterns HBsAg kinetics CHB patients who achieved loss during pegylated interferon (PEG-IFN) α-2a. Methods: A total 150 were enrolled, composing 83 envelope (HBeAg)-positive 67 HBeAg-negative patients. Patients treated with PEG-IFN α-2a180 μg/week until was achieved, which occurred...
Abstract To investigate whether the changes in nicotinic receptors (nAChRs) and learning memory associated with Alzheimer's disease (AD) are influenced by both β‐amyloid peptide (Aβ) cholesterol vivo, we examined effects of intracerebroventricular injection Aβ 1–42 and/or a high‐cholesterol diet on brain levels ofnAChRs rats. The nAChR subunit proteins corresponding mRNA were measured Western blotting RT‐PCR, respectively; evaluated Morris Water Maze examination. Injection resulted...
Cytokines play an important role in occurrence and recovery of hepatitis B virus (HBV) infection. The aim this study was to investigate the changes cytokines concentration its correlation alanine aminotransferase (ALT), HBV deoxyribonucleic acid (HBV-DNA), envelope antigen (HBeAg), surface (HBsAg) development chronic (CHB).Thirteen healthy individuals (HI), 30 HBV-infected patients immune tolerant (IT) phase, 55 CHB were enrolled between August 2015 May 2017. peripheral blood samples...
Plasmacytoid dendritic cells (pDCs) are crucial for control of chronic hepatitis B (CHB) virus infection. In this study, we evaluated the frequencies pDCs and expression functional molecules on in patients treated with PEG-IFN-α-2a or entecavir (ETV) investigated changes during treatment. The mean fluorescence intensity CD86 (CD86MFI) surface CD86+ peripheral blood were measured. Compared baseline, pDC% CD86MFI increased obviously after treatment 12 24 weeks. For ETV, only observably weeks...
Background. To explore the role of natural killer (NK) cells in process hepatitis B virus (HBV) clearance and whether their phenotype is related to antiviral treatment outcome chronic (CHB) patients. Method. We performed a single-center prospective cohort study analyze changes NK at weeks 12 24 from baseline CHB patients who received PEGylated-interferon- (PEG-IFN-) α-2a versus entecavir. The frequencies NK, CD56bright, CD56dim, IFNAR2+, NKp46+, NKp46bright, NKp46dim mean fluorescence...
Hepatitis B is an immune response-mediated disease. The aim of this study was to explore the differences ratios T-helper (Th) 2 cells Th1 and cytokine levels in acute hepatitis (AHB) patients chronic virus (HBV)-infected immune-tolerance immune-active phases.Thirty HBV-infected immune-tolerant phase (IT group) 50 (clearance) (IC group), 32 AHB (AHB 13 healthy individuals (HI were enrolled study. Th cell proportions peripheral blood, plasma, serum HBV DNA, surface antigen, e antigen...
Background To investigate the changes of human leukocyte antigen DR (HLA-DR) and CD38 coexpression subsets on T lymphocytes following interferon (IFN) therapy for those who have chronic hepatitis B (CHB). Methods A prospective cohort CHB patients participated in this study. without IFN treatment (including naïve nucleoside [nucleotide] analogs [NAs]-treated patients) were given pegylated alfa (Peg-IFNα) treatment. Peripheral blood samples taken at baseline, 4 weeks 12-24 Peg-IFNα For entered...
Estimating the grades of liver inflammation is critical in determination antiviral therapy patients chronically infected with hepatitis B virus (HBV). The aim this study was to investigate correlation serum levels surface antigen (HBsAg) and e (HBeAg) treatment-naïve chronic HBV infection.We retrospectively enrolled 584 HBeAg-positive who underwent biopsy Ditan Hospital from January 2008 2016. Based on severity inflammation, were divided into minimal, mild, moderate groups. SPSS software...
Plasmacytoid dendritic cells (pDCs) and cytokines play an important role in occurrence recovery of hepatitis B virus (HBV) infection. The aim this study was to explore the frequency function pDC serum cytokine network profiles patients with acute or chronic HBV infection.The healthy individuals (HI group), envelope antigen (HBeAg)-positive immune tolerance (IT) phase (IT HBeAg-positive (CHB (AHB group) were enrolled study. cluster differentiation 86 (CD86) + counts CD86 molecular expressed...
Objective The ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear surface antigen (HBsAg). This study aimed evaluate whether the expression functional molecules on plasmacytoid dendritic cells (pDCs) associated with HBsAg loss HBeAg-positive during peginterferon alpha-2a (PEG IFN α-2a) therapy. Methods A single-center prospective cohort was performed CHB who were treated PEG-IFN α-2a and followed up for 4 years. clearance, HBeAg undetectable HBV DNA achieved...
Objective To explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in e envelope (HBeAg)-positive patients with chronic (CHB) throughout peginterferon alpha-2a (PEG-IFN α-2a) treatment. Methods In this prospective research, HBeAg-positive CHB received PEG-IFN α-2a treatment, completing 4-year follow-up. After undetectable HBV DNA, HBsAg loss, HBeAg were defined as cure....
Objective Precise assessment of liver inflammation in untreated hepatitis B e antigen (HBeAg)-positive patients with chronic virus (HBV) infection can determine when to initiate antiviral therapy. The aim this study was develop and validate a nomogram model for the prediction non-minimal based on pathological injuries combined age alanine aminotransferase (ALT), aspartate (AST), surface (HBsAg), HBeAg, HBV DNA quantification. Methods We retrospectively included 735 HBeAg-positive (CHB) ALT...