A5100625865- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- interferon and immune responses
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Sirtuins and Resveratrol in Medicine
- Folate and B Vitamins Research
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Animal Virus Infections Studies
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- Traditional Chinese Medicine Studies
- Influenza Virus Research Studies
- Machine Learning in Bioinformatics
- Cytomegalovirus and herpesvirus research
- Lipid metabolism and disorders
- Natural Compounds in Disease Treatment
Beijing Ditan Hospital
2016-2025
Capital Medical University
2016-2025
Peking University
2011-2024
Shazhou Professional Institute Of Technology
2024
University of Benin
2024
Tianjin Special Equipment Supervision and Inspection Technology Research Institute
2024
Capital University
2010-2023
Hangzhou Medical College
2021
Beihang University
2020
Chinese Center For Disease Control and Prevention
2020
Background and Purpose— Epidemiological patterns of stroke may change with economic development. It is important to understand these changes for making timely strategies prevention. The aim this study was examine the in trends epidemiology during a period fast development China, based on data Sino-MONICA-Beijing project. Methods— Acute events were registered large defined population aged 25 through 74 years from 1984 2004. age standardized incidence rates case fatality total stroke, ischemic...
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Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, natural compound extracted from mulberry drug used as capillary stabilizer clinically for many years without any side effects, regulated whole-body metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased expenditure, improved glucose homeostasis in both genetically obese (Db/Db) diet-induced...
<h3>Objective</h3> The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) during chronic (CHB) treatment is limited. aim this study was to determine performance anti-HBc as a predictor for e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with peginterferon (Peg-IFN) or nucleos(t)ide analogues (NUCs), respectively. <h3>Design</h3> This retrospective cohort consisting 231 and 560 enrolled two phase IV, multicentre,...
The translation of human triosephosphate isomerase (TPI) mRNA normally terminates at codon 249 within exon 7, the final exon. Frameshift and nonsense mutations TPI gene that cause to terminate prematurely or upstream 189, 6, result in a decreased level (I.O. Daar L.E. Maquat, Mol. Cell. Biol. 8:802-813, 1988). For all this group, decrease is same extent, i.e., approximately 20% normal level. We show here second group downstream 208, did not affect abundance. Deletion analysis demonstrated...
Frameshift and nonsense mutations within the gene for human triosephosphate isomerase (TPI) that generate a codon first three-fourths of protein coding region have been found to reduce abundance product mRNA copurifies with nuclei. The cellular process location codon-mediated reduction proven difficult elucidate technical reasons. We show here, using electron microscopy judge purity isolated nuclei, previously established 25% normal level is evident nuclei are free detectable cytoplasmic...
China will experience an overall growth and aging of its adult population in coming decades. We used a computer model to forecast the future impact these demographic changes on coronary heart disease (CHD) China.The CHD Policy Model is validated state-transition, simulation national scale. China-specific risk factor, incidence, case-fatality, prevalence data were incorporated, prediction was generated from Chinese cohort study calibrated age-specific mortality rates. Disability-adjusted life...
The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate patients. efficacy current treatment strategies is low as usually initiated following onset symptoms. Inflammation one main mechanisms autoimmune disorders and a common feature sepsis. suppression inflammation therefore an important mechanism for Sirtuin 1 (Sirt1) has been demonstrated to play role in regulation inflammation. Resveratrol, potent Sirt1 activator, exhibits anti‑inflammatory properties....
An optimization strategy based on the Roadmap concept is supposed to improve clinical outcomes of patients with suboptimal antiviral response. The aim this study was prove a multicenter, open-label, randomized, controlled study. In all, 606 hepatitis B e antigen (HBeAg)-positive, nucleos(t)ide-naive chronic were randomized Optimize or Mono group. Patients in group treated telbivudine for 24 weeks, after which those responders HBV DNA ≥300 copies/mL at week received plus adefovir until 104,...
Our previous studies unexpectedly indicated that the level of serum hepatitis B core antibody (anti-HBc) was positively correlated with alanine aminotransferase (ALT) level. The aim this study to determine whether anti-HBc could serve as a potential biomarker for detection liver inflammation in chronic (CHB) patients, especially patients normal ALT levels. Serum levels were quantified 655 treatment-naïve CHB including 45 who underwent two biopsies (baseline phase and 78th weeks...
ABSTRACT Objectives This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on survival rates and incidence liver cancer in patients alcohol‐related disease (ARLD). Methods Patients ARLD those co‐morbid CHB were included this designated as group + HBV group, respectively. Propensity score matching (PSM) was then employed compare development between these two groups. Results Among 404 patients, 254 150 group. After propensity matching, each comprised 67...
Response-guided therapy has been confirmed to be an effective strategy for the treatment of chronic hepatitis C in pegylated interferon (PegIFN) era, but no randomized trial utilizing this conducted B.In open-label, multicenter, trial, HBeAg positive patients were treated with PegIFN (180μg/week) 24weeks. Early responders (HBsAg <1500IU/ml and HBV DNA <10(5)copies/ml at week 24) received a further 24weeks (arm A), while non-early another B), 72weeks C) or plus adefovir 36weeks D). The...
Summary Liver biopsy is not routinely performed in treated chronic hepatitis B. stiffness measurement has been validated for noninvasive liver fibrosis assessment pretreatment B but assessed monitoring during antiviral therapy. was systemically monitored by Fibroscan ® every 6 months a cohort of patients with receiving therapy and compared biopsies at baseline week 104. A total 534 e antigen‐positive treatment‐naive telbivudine‐based qualified 104 were analyzed, 164 which had adequate paired...
Little is known on the cost-effectiveness of novel regimens for hepatitis C virus (HCV) compared with standard-of-care pegylated interferon (pegIFN) and ribavirin (RBV) therapy in developing countries. We evaluated sofosbuvir/ledipasvir 12 weeks a 48-week pegIFN-RBV regimen Chinese patients genotype 1b HCV infection by economic regions.A decision analytic Markov model was developed to estimate quality-adjusted-life-years, lifetime cost incremental ratios (ICERs). SVR rates direct medical...
Recent guidelines of the American Association for Study Liver Diseases, European Liver, and Asian Pacific 2008 update "Asian-Pacific consensus statement on management chronic hepatitis B" offer comprehensive recommendations general B (CHB). These highlight preferred approaches to prevention, diagnosis, treatment CHB. Nonetheless, results recent studies have led an improved understanding disease a belief that current specific therapeutic considerations, including CHB initiation cessation...
Hepatitis C virus (HCV) genotype and subtype are related to disease progression response antiviral therapy. Current HCV distribution data, especially for genotypes 3 6, limited in China. Our purpose was investigate the current distributions chronic hepatitis patients China.Chronic (n = 1012) were enrolled, demographic information possible transmission risk factors collected. Serum samples subjected reverse-transcription polymerase chain reaction, followed by direct DNA sequencing...
Summary Tenofovir disoproxil fumarate ( TDF ) has demonstrated long‐term efficacy and a high barrier to resistance in multiple chronic hepatitis B CHB populations outside of China. This study aimed evaluate the safety compared with adefovir dipivoxil ADV Chinese patients during 48 weeks treatment (ClinicalTrial.gov number, NCT01300234). A Phase 3, multicentred, randomized, double‐blind, controlled trial . The primary endpoint was proportion HBV DNA <400 copies/mL each group at Week 48,...
Abstract Background and aim Long-term treatment with tenofovir disoproxil fumarate (TDF) has demonstrated suppression of viral replication outside China. This study aims to assess efficacy, resistance safety TDF for up 240 weeks in Chinese patients chronic hepatitis B virus (HBV) infection. Methods Patients (HBeAg-positive or HBeAg-negative) who were randomised receive 300 mg adefovir dipivoxil (ADV) 10 once daily the 48-week double-blind phase ( N = 498) eligible enter open-label (TDF–TDF...