A5023616038- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Genetic and phenotypic traits in livestock
- Effects of Environmental Stressors on Livestock
- Sirtuins and Resveratrol in Medicine
- Dietary Effects on Health
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Infrastructure Maintenance and Monitoring
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Mechanical Failure Analysis and Simulation
- Alcohol Consumption and Health Effects
- Circadian rhythm and melatonin
- Gut microbiota and health
- Muscle metabolism and nutrition
- Machine Fault Diagnosis Techniques
- Cancer Mechanisms and Therapy
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and biosynthesis
First Affiliated Hospital of Jiangxi Medical College
2025
University of Chinese Academy of Sciences
2016-2023
Chinese Academy of Sciences
2016-2023
Institute of Zoology
2016-2023
Guangdong University of Technology
2020
China Academy of Chinese Medical Sciences
2019
Objective Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused short-chain fatty acids produced by gut microbiota. Ginseng been reported to aid in body weight management, however, its mechanism action is not yet clear. In this study, we potential modulating effect ginseng microbiota, aiming identify specific strains their metabolites, especially long-chain (LCFA), which mediate anti-obesity ginseng. Design Db/db mice were gavaged with extract...
Significance In the current study, we show that brown adipose tissue (BAT) activity is dramatically reduced in a dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat when compared with normal control rat. Importantly, key features of PCOS (such as insulin resistance and irregular estrous cycle) are alleviated after BAT transplantation. Mechanistically, transplanted enhances endogenous thereby increases circulating adiponectin level, which was lower both patient model....
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, natural compound extracted from mulberry drug used as capillary stabilizer clinically for many years without any side effects, regulated whole-body metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased expenditure, improved glucose homeostasis in both genetically obese (Db/Db) diet-induced...
White adipose tissue expansion is associated with both hypertrophy and hyperplasia of adipocytes. Exercise training results in adipocyte hypotrophy by activating lipolysis, but it poorly understood whether exercise regulates adipogenesis altering adipogenic gene expression. The purpose this study was to evaluate the effect a single bout swimming on expression white (WAT). Male C57BL/6J mice were divided into two groups: sedentary control group 120-minute group. Immediately after acute...
Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter-organ systems play key role in IF remains unclear. Here, novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss function studies and therapeutic experiment mice revealed that PZP promotes diet-induced thermogenesis activating brown adipose tissue (BAT)....
Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disease affecting women of reproductive age. Due to its complex aetiology, there no currently effective cure for PCOS. Brown adipose tissue (BAT) activity significantly decreased in PCOS patients, BAT activation has beneficial effects animal models Here, we investigated the effect ginsenoside compound K (CK) an model mechanism activation.Primary brown adipocytes, Db/Db mice dehydroepiandrosterone (DHEA)-induced rats were...
Polycystic ovary syndrome (PCOS) is a common endocrine disease accompanied by energetic metabolic imbalance. Because the etiology of PCOS complex and remains unclear, there no effective specific treatment for PCOS. It often various disorders such as obesity, insulin resistances, others. Activated brown adipose tissue (BAT) consumes excess energy via thermogenesis, which has positive effects on metabolism. Our previous research that others indicates BAT activity decreased in patients,...
Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance domestic animals, we sequenced genomes 28 cattle from warm and areas across China. By characterizing population structure demographic history, identified two genetic clusters, i.e., northern southern groups, well common historic peak at 30 kilo years ago. Genomic scan cold-tolerant breeds determined potential candidate genes thermogenesis-related...
PA treatment effectively and safely protected against obesity via the BAT-UCP1 axis. has therapeutic potential for treating type II diabetes.
Brown adipose tissue (BAT), an organ that burns energy through uncoupling thermogenesis, is a promising therapeutic target for obesity. However, there are still no safe anti-obesity drugs BAT in the market. In current study, we performed large scale screening of 636 compounds which were approved by Food and Drug Administration (FDA) to find could significantly increase protein 1 (UCP1) mRNA expression real-time PCR. Among those UCP1 activators, most them antibiotics or carcinogenic...
The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account this. It demonstrated that erupting of pregnancy zone protein (PZP) from liver coincides with membrane translocation grp78 brown adipocytes during to activate (BAT), which partly explain metabolic benefits IFR. Liver-derived PZP appears be responsible all regulatory...
The transforming growth factor β (TGFβ) signaling pathway plays a crucial role in the development of liver fibrosis by activating TGFβ type II receptor (TGFβR2), followed recruitment TGFβR1 finally triggering downstream pathway.To find drugs targeting TGFβR2 that inhibit TGFβR1/TGFβR2 complex formation, theoretically pathway, and thereby ameliorate fibrosis.Food Drug Administration-approved were screened for binding affinity with virtual molecular docking. We identified 6 candidates further...
White adipose tissue (WAT) browning may have beneficial effects for treating metabolic syndrome. miRNA are important regulators of the differentiation, development, and function brown beige adipocytes. Here, we found that cold-inducible miRNA17-92 cluster is enriched in (BAT) compared with WAT. Overexpression miR17-92 C3H10T1/2 cells, a mouse mesenchymal stem cell line, enhanced thermogenic capacity Furthermore, observed significant reduction adiposity tissue-specific transgenic (TG) mice....
Performance feature extraction is the primary problem in equipment performance degradation assessment. To handle of high-dimensional characterization and complexity calculating indicators flexible material roll-to-roll processing, this paper proposes a PCA method for extracting characteristic roll shaft. Based on analysis influencing factors processing roller, principal component model was constructed. The original parameter matrix composed 10-dimensional parameters such as time domain,...
Environmental temperature serves a major driver for adaptive changes in wild organisms, however, its role domestication has been less characterized. To uncover the mechanisms of cold tolerance domestic animals, we sequenced genomes 28 cattle at median coverage from warm and areas across China. By characterizing population structure demographic history, identified two genetic clusters, i.e., northern southern groups, common historic peak 30 kilo years ago. Genome scan tolerant breeds revealed...
Abstract Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge-drinking, can cause serious damage. Reducing consumption or absorption direct way to alleviate this harm. decomposed successively by dehydrogenase (ADH) and acetaldehyde (ALDH) the liver. Many anti-hangover drugs are intended increase activity these two enzymes, which weakened many people owing gene polymorphisms. Here, we produced high-activity...