A5101687532- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Meat and Animal Product Quality
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Sirtuins and Resveratrol in Medicine
- Viral gastroenteritis research and epidemiology
- Aquaculture Nutrition and Growth
- Ovarian function and disorders
- Liver physiology and pathology
- MicroRNA in disease regulation
- Effects of Environmental Stressors on Livestock
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Genetic and phenotypic traits in livestock
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Fatty Acid Research and Health
Chinese Academy of Sciences
2015-2025
Lanzhou University
2024-2025
Institute of Modern Physics
2024-2025
Dalian Polytechnic University
2019-2024
Institute of Zoology
2014-2023
University of Chinese Academy of Sciences
2015-2023
Qilu Hospital of Shandong University
2015-2022
Tianjin Medical University Eye Hospital
2021
Tianjin Medical University
2021
China Academy of Chinese Medical Sciences
2019
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted from C57/BL6 mice into the dorsal subcutaneous region age- and sex-matched leptin deficient Ob/Ob Interestingly, led to significant reduction body weight gain with increased oxygen consumption...
Objective Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused short-chain fatty acids produced by gut microbiota. Ginseng been reported to aid in body weight management, however, its mechanism action is not yet clear. In this study, we potential modulating effect ginseng microbiota, aiming identify specific strains their metabolites, especially long-chain (LCFA), which mediate anti-obesity ginseng. Design Db/db mice were gavaged with extract...
Significance In the current study, we show that brown adipose tissue (BAT) activity is dramatically reduced in a dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat when compared with normal control rat. Importantly, key features of PCOS (such as insulin resistance and irregular estrous cycle) are alleviated after BAT transplantation. Mechanistically, transplanted enhances endogenous thereby increases circulating adiponectin level, which was lower both patient model....
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, natural compound extracted from mulberry drug used as capillary stabilizer clinically for many years without any side effects, regulated whole-body metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased expenditure, improved glucose homeostasis in both genetically obese (Db/Db) diet-induced...
Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold. Nevertheless, several pig breeds are known be cold resistant. The molecular mechanism(s) enabling such adaptation currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends UCP3 and white adipose tissue (WAT) browning. In two cold-resistant (Tibetan Min), a cold-sensitive breed (Bama), WAT browning was induced after exposure. Beige adipocytes from Tibetan pigs...
DJ-1 protein is involved in multiple physiological processes, including Parkinson's disease. However, the role of metabolism largely unknown. Here we found that maintained energy balance and glucose homeostasisvia regulating brown adipose tissue (BAT) activity. DJ-1-deficient mice reduced body mass, increased expenditure improved insulin sensitivity. deletion also resisted high-fat-diet (HFD) induced obesity resistance. Accordingly, transgene triggered autonomous intolerance. Further BAT...
Alcohol is an essential drug in human life with multiple medical functions, but excessive alcohol intake, even a single episode of binge drinking, can cause serious damage. Reducing consumption or absorption direct way to alleviate the related harm. decomposed successively by dehydrogenase (ADH) and acetaldehyde (ALDH) liver. Here, we produced ADH1B (hADH1B)-expressing probiotic, recombinant Lactococcus lactis, that aimed enhance degradation intestinal tract after oral administration. Our...
Gliomas are characterized by aggressive behavior, leading to severe disability and high mortality. Ubiquitin-like modifier activating enzyme 2 (UBA2) is a subunit of the E1-activating involved in SUMOylation (SUMO, small ubiquitin-related modifier) numerous proteins. Although abnormality
Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter-organ systems play key role in IF remains unclear. Here, novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss function studies and therapeutic experiment mice revealed that PZP promotes diet-induced thermogenesis activating brown adipose tissue (BAT)....
Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disease affecting women of reproductive age. Due to its complex aetiology, there no currently effective cure for PCOS. Brown adipose tissue (BAT) activity significantly decreased in PCOS patients, BAT activation has beneficial effects animal models Here, we investigated the effect ginsenoside compound K (CK) an model mechanism activation.Primary brown adipocytes, Db/Db mice dehydroepiandrosterone (DHEA)-induced rats were...
Increasing evidence suggests that brown adipose tissue (BAT) plays an important role in obesity and related diseases.
Polycystic ovary syndrome (PCOS) is a common endocrine disease accompanied by energetic metabolic imbalance. Because the etiology of PCOS complex and remains unclear, there no effective specific treatment for PCOS. It often various disorders such as obesity, insulin resistances, others. Activated brown adipose tissue (BAT) consumes excess energy via thermogenesis, which has positive effects on metabolism. Our previous research that others indicates BAT activity decreased in patients,...
Abstract Background& Aims The Coronavirus Disease 2019 (COVID-19) has become a global epidemic and caused lasting huge loss of life security, economic development social stability in more than 180 countries around the world. Unfortunately, there is still no specific treatment for COVID-19 till now, therefore, at this point, all potential therapies need to be critically considered. LL-37 one best-studied human antimicrobial peptide (AMPs) that broad-spectrum activity against bacteria...
Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance domestic animals, we sequenced genomes 28 cattle from warm and areas across China. By characterizing population structure demographic history, identified two genetic clusters, i.e., northern southern groups, well common historic peak at 30 kilo years ago. Genomic scan cold-tolerant breeds determined potential candidate genes thermogenesis-related...
PA treatment effectively and safely protected against obesity via the BAT-UCP1 axis. has therapeutic potential for treating type II diabetes.
Fibroblast growth factor 21 (FGF21), a metabolism regulator, has an important effect on metabolic diseases, such as obesity and diabetes. It is also expressed in mice, the murine source high homology with human FGF21. Recently, it been extensively studied become potential drug target for treatment of diseases. As protein-based hormone, FGF21 cannot be easily quickly absorbed into blood through oral administration. Moreover, 0-2 h half-life vivo , shown previous study, thus its efficacy lasts...
Obeticholic acid (OCA) is exemplified as a potent drug for treating primary biliary cirrhosis and nonalcoholic fatty liver disease by inhibiting bile synthesis. However, it remains unclear whether the effect of OCA mediated function brown adipose tissue (BAT). In present study, adipogenesis differentiation <em>in vitro</em> db/db mouse model treated with were used to assess anti‑obesity body weight tracking, O2 consumption, food intake, physical activity, glucose tolerance tests. addition,...
Brown adipose tissue (BAT), an organ that burns energy through uncoupling thermogenesis, is a promising therapeutic target for obesity. However, there are still no safe anti-obesity drugs BAT in the market. In current study, we performed large scale screening of 636 compounds which were approved by Food and Drug Administration (FDA) to find could significantly increase protein 1 (UCP1) mRNA expression real-time PCR. Among those UCP1 activators, most them antibiotics or carcinogenic...