A5101432434- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Fish Biology and Ecology Studies
- COVID-19 epidemiological studies
- Fish Ecology and Management Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Fish biology, ecology, and behavior
- Genomics and Phylogenetic Studies
- HIV/AIDS drug development and treatment
- Identification and Quantification in Food
- Liver physiology and pathology
- Fault Detection and Control Systems
- Soil Moisture and Remote Sensing
- Neurobiology and Insect Physiology Research
- Proteoglycans and glycosaminoglycans research
- Systemic Lupus Erythematosus Research
- Advanced Control Systems Design
- Genetic diversity and population structure
- Retinal Development and Disorders
- 14-3-3 protein interactions
Hainan Medical University
2020-2023
Hainan General Hospital
2013-2023
University of Chinese Academy of Sciences
2021-2023
Southern Medical University
2018-2022
Kunming Institute of Zoology
2021-2022
Chinese Academy of Sciences
2010-2022
Zhejiang Center for Disease Control and Prevention
2022
Warren Wilson College
2021
General Hospital of Central Theater Command
2020
Central Hospital of Wuhan
2020
Abstract Background A cluster of acute respiratory illness, now known as Corona Virus Disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases are more likely be to infected SARS-CoV-2 and result in severe outcomes elevated case-fatality rate. Meanwhile, have high prevalence the middle-aged elderly population. However, despite several researches COVID-19, implications related it still remains largely unclear....
Abstract Background Since January 2020, coronavirus disease 2019 (Covid-19) has spread rapidly and developing the pandemic model around world. Data have been needed on clinical characteristics of affected patients in an imported cases as island outside Wuhan. Methods We conducted a retrospective study included all 168 confirmed Covid-19 Hainan province from 22 2020 to 13 March 2020. Cases were by real-time RT-PCR analysed for demographic, clinical, radiological laboratory data. Results Of...
Background It has been reported that strict non-pharmaceutical measures can significantly reduce the incidence and mortality of respiratory intestinal infectious diseases during COVID-19 pandemic, but there are limited reports on impact in terms rates zoonotic diseases. Methods We extracted data eight notifiable from website National Health Commission People’s Republic China for period January 2015 to April 2021. Results First, overall decreased 0.3714 per 100 000 2015–2019 0.2756 2020...
Aedes (Stegomyia) albopictus, also known as the Asian tiger mosquito, is a mosquito which originated in Asia. In recent years, it has become increasingly rampant throughout world. This can transmit several arboviruses, including dengue, Zika and chikungunya viruses, considered public health threat. Despite urgent need of genome engineering to analyze specific gene functions, progress genetical manipulation Ae. albopictus been slow due lack efficient methods genetic markers. present study, we...
The Asian tiger mosquito, Aedes albopictus, an increasingly relevant arboviral vector, has spread worldwide. However, currently available tools are limited in terms of effective monitoring vector populations and accurate determination the extent viral transmission, especially before during outbreaks. Therefore, it is essential to develop novel surveillance tools, particularly those that target adult mosquitoes enhance trapping efficiency for Ae. albopictus.A variety human body odorants...
Sofosbuvir is a nucleotide analog inhibitor of the hepatitis C virus (HCV) NS5B RNA polymerase with pangenotypic potency. This phase 3b study evaluated safety and efficacy sofosbuvir + ribavirin ± peginterferon in Chinese patients infected HCV genotype 1, 2, 3, or 6.Patients 1 6 received peginterferon/ribavirin for 12 weeks 24 weeks, depending on prior treatment interferon eligibility. Patients 2 3 respectively. The primary endpoint was sustained virologic response at after end (SVR12).Of...
Effective management of imported cases is an important part epidemic prevention and control. Hainan Province, China reported 168 coronavirus disease 2019 (COVID-19), including 112 on February 19, 2020, but successfully contained the within 1 month. We described epidemiological clinical characteristics COVID-19 in compared these features between local to provide information for other international areas.We included 91 patients (56 35 cases) from two designated hospitals Haikou, China, January...
Background/Aims: Different genotypes of HCV may differ in both disease progression and response to antiviral therapies. Hainan Island has been inhabited by the “Li” aboriginal minority for centuries. We aimed provide a better understanding infection on Island, so that information would help improve strategies prevention control island wider country. Methods: Using RT-PCR DNA sequencing, we determined sequences from 100 patients living Island. Results: Phylogenetic analysis classified these...
Abstract BACKGROUND Aedes albopictus is the primary vector of mosquito‐borne diseases, including dengue and chikungunya, in China. The management mosquitoes strategy for control such infectious diseases. gravid Ae. prefers to skip‐oviposit its eggs into different small water containers, these breeding places critical mosquito . Bacillus thuringiensis subspecies Israelensis (Bti) a useful biological larvicide, but effective period currently available commercial product relatively short. This...
Much research has focused on visual system evolution in bony fishes. The capacity of systems to perceive and respond external signals is integral evolutionary success. However, integrated the mechanisms adaptive based corneal structure related genes remains limited. In this study, scanning electron microscopy (SEM) was used assess microstructure adaptation epithelial cells. Then, cornea-related COL8A2 gene investigated. We found various projections (microridges, microplicae, microholes,...
ABSTRACT This paper uses multi-year, individual-level data to evaluate the effects of current Chinese urban employee health insurance reform on equity in care financing. It found that new Urban Employee Basic Health Insurance Scheme financed by personal medical savings accounts (MSAs) plus a social-risk pooling account (SPA) is regressive. The contributions SPA, although slightly regressive, played an important role equalizing financial burden; payments from SPA favored low-income insured...
Background/Aims: Hainan Island has been inhabited by the “Li” aboriginal minority for centuries where HCV genotype distribution patterns maybe remarkably different from other parts of China. We aimed to provide a better understanding infection with 6 among aboriginals on Island. Methods: Firstly, using RT-PCR and DNA sequencing determined 517 partial Core-E1(115 Li Ethnic, 402 Han Ethnic) 8 full-length genomes ethnic in successfully, then phylogenetic tree determine analyze evolution them....
Background The surveillance of vector mosquitoes is essential for prevention and control mosquito-borne diseases. In this study, we developed an internet-based mosquito monitor, MS-300, evaluated its efficiency the capture important mosquitoes, Aedes albopictus Culex quinquefasciatus , in laboratory field trials. Methodology/Principal findings linear sizes adult Ae . Cx were measured infrared window was designed based on these data. A device to specifically attract two species automatically...
Abstract Background : Hainan Island, a popular tourist destination, had received many imported cases of Coronavirus disease 2019 (COVID-19), but successfully contained the epidemics in one month. We described epidemiological and clinical characteristics COVID-19 compared these features between local to provide information for other international epidemic areas. Methods: included 91 patients (56 35 cases) from two designed hospitals Haikou, China, January 20 February 19, 2020. Data on...
Physoschistura longibulla, a new species and the first of revised genus from Pyin Oo Lwin Irrawaddy basin, can be distinguished other congeners by combination following characters: posterior chamber air bladder well developed, connecting anterior with long thin tube, oval; dorsal fin 81/2 branched rays, its origin slightly to pelvic-fin base vertically; lateral line complete straight, 93–102 pores; pectoral 8–9 reaching 1/2 2/3 distance base; suborbital flap absent in male; axillary pelvic...
Molecular biology of liver disorders: The hepatitis C virus and molecular targets for drug development
Exostoma gaoligongense is an endemic glyptosternine catfish distributed in the Nujiang River drainage, Yunnan Province, China, with few published genetic information. In this study, we sequenced and characterized complete mitochondrial genome of E. gaoligongense, which was circular, 16529 bp length, containing 13 protein-coding genes, 22 tRNA 2 rRNA one replication origin control region. Phylogenetic analysis revealed that had closest relationship its congener labiatum. They clustered clade...
Lymphocyte activation results in profound changes the abundance of m RNA transcripts many which are downregulated. The W iskott– A ldrich syndrome (WAS) protein ( WASP ) family is critical for productive T‐cell receptor signaling and actin reorganization. signal pathway includes WAS/WAS‐like (WASL) interacting 2 WIPF 2) gene also known as WIRE / WICH . We show that both human WIPF2 mouse Wipf2 mice, alternatively spliced within 3′ untranslated region (3′ UTR resulting two major approximately...
There is limited evidence regarding particulate matter (PM)'s short-term effects on pulmonary tuberculosis (PTB) hospital admission. Our study aimed to determine the associations of exposure ambient PM with aerodynamic diameters <2.5 μm (PM2.5) and < 10 (PM10) admission for PTB in Hainan, a tropical province China. We collected individual data patients hospitalized PTB, PM2.5, PM10, meteorological from 2016 2019 Hainan Province, Conditional logistic regression models time-stratified...
In analogy to the Internal Bubble Sort we have developed an external sort paradigm which when implemented proves be significantly faster than Friedman/Lin and Merge-Sort under certain conditions. Its time complexity is estimated (N^2 Log N) or better. Possible refinements are also mentioned.
Background and Aims: Emitasvir is a new type of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, the data phase 2 trial has shown emitasvir-sofosbuvir to have good safety tolerance. We conducted this 3 further verify efficacy safety.
Background: Hainan Island, a popular tourist destination, had received many imported cases of Coronavirus disease 2019 (COVID-19), but successfully contained the epidemics in one month. We described epidemiological and clinical characteristics COVID-19 compared these features between local to provide information for other international epidemic areas.Methods: included 91 patients (56 35 cases) from two designed hospitals Haikou, capital province, January 20 February 19, 2020. Data on...